Pick Disease Differential Diagnoses

  • Author: Anna M Barrett, MD; Chief Editor: Michael Hoffmann, MBBCh, MD, FCP(SA), FAAN, FAHA   more...
 
Updated: May 14, 2012
 
 

Diagnostic Considerations

Conditions to consider in the differential diagnosis of Pick disease include the following:

  • Cardioembolic stroke
  • Subdural hematoma
  • Brain tumors of the frontal lobe, pituitary or related regions
  • Adult polyglucosan body disease
  • Chronic meningitis
  • Hashimoto encephalopathy
  • Hemochromatosis (controversial)
  • Neurosarcoidosis
  • Dementia in Parkinson disease
  • Dementia in progressive supranuclear palsy
  • Creutzfeldt-Jakob disease
  • Olfactory groove meningioma
  • Tertiary neurosyphilis
  • Sequential bilateral thalamic strokes
  • Herpes simplex encephalitis
  • Huntington disease
  • Hydrocephalus
  • Hyperammonemia
  • Inherited metabolic disorders
  • Lyme disease
  • Marchiafava-Bignami disease
  • Multiple sclerosis
  • Multiple system atrophy
  • Neuroacanthocytosis
  • Prion-related diseases

Differential Diagnoses

Proceed to Workup
 
 
Contributor Information and Disclosures
Author

Anna M Barrett, MD  Director, Stroke Rehabilitation Research Program, Kessler Foundation Research Center; Chief, Neurorehabilitation Program Innovation, Kessler Institute of Rehabilitation; Professor of Physical Medicine and Rehabilitation and Neurology and Neurosciences, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Anna M Barrett, MD is a member of the following medical societies: American Academy of Neurology, American Society of Neurorehabilitation, and International Neuropsychological Society

Disclosure: Pfizer/Eisai Grant/research funds Other; Wallerstein Foundation for Geriatric Improvement Grant/research funds Speaking and teaching; OBrien Technologies Grant/research funds Independent contractor; Kessler Foundation Salary Employment; National Institutes of Health Grant/research funds Other

Chief Editor

Michael Hoffmann, MBBCh, MD, FCP(SA), FAAN, FAHA  Professor of Neurology, University of Central Florida College of Medicine; Director of Cognitive Neurology, Director of Stroke Program, James A Haley Veterans Affairs Hospital

Michael Hoffmann, MBBCh, MD, FCP(SA), FAAN, FAHA is a member of the following medical societies: American Academy of Neurology, American Headache Society, American Heart Association, and American Society of Neuroimaging

Disclosure: Nothing to disclose.

Additional Contributors

Daniel H Jacobs, MD, FAAN Associate Professor of Neurology, University of Florida College of Medicine

Daniel H Jacobs, MD, FAAN is a member of the following medical societies: American Academy of Neurology, American Society of Neurorehabilitation, and Society for Neuroscience

Disclosure: Teva Pharmaceutical Grant/research funds Consulting; Biogen Idex Grant/research funds Independent contractor; Serono EMD Royalty Speaking and teaching; Pfizer Royalty Speaking and teaching; Berlex Royalty Speaking and teaching

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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Motor perseveration in a patient with Pick disease. The patient was asked to copy loops (as demonstrated by the examiner in the first line).
 
 
 
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