Muscle Contraction Tension Headache Treatment & Management
- Author: Manish K Singh, MD; Chief Editor: Howard A Crystal, MD more...
Medical Care
- Management of TTH consists of pharmacotherapy, psychophysiologic therapy, and physical therapy.
- Treatment of headache must be tailored for individual patients.
- Recognition of comorbid illness is essential. Migraine may be associated with TTH, and management overlaps. Other associated conditions may include depression, anxiety, and emotional or adjustment disorders.
- Management of CTTH with a combination of tricyclic antidepressant medication and stress management therapy may result in a better outcome than monotherapy.[4]
- Pharmacotherapy consists of abortive therapy (to stop or reduce severity of the individual attack) and long-term preventive therapy. Preventive drugs are the main therapy for CTTH, but they seldom are needed for ETTH.
- These headaches (especially ETTH) generally respond to simple over-the-counter (OTC) analgesics such as paracetamol (ie, acetaminophen), ibuprofen, aspirin, or naproxen.
- If treatment is unsatisfactory, the addition of caffeine or use of prescription drugs is recommended. If possible, avoid use of barbiturates or opiate agonists.
- Also discourage overuse of all symptomatic analgesics because of the risk of dependence, abuse, and development of chronic daily headache.
- Fiorinal with codeine is generally significantly more effective than placebo or Fiorinal alone. The combination is also significantly better than codeine alone in relieving pain and maintaining ability to perform daily activities. However, Fiorinal with codeine is not first-line therapy and carries a significant risk of abuse.
- Consider preventive medications if the headaches are frequent (>2 attacks per wk), of long duration (>3-4 h), or severe enough to cause significant disability or overuse of abortive medication.
- Amitriptyline (Elavil) and nortriptyline (Pamelor) are the most frequently used tricyclic antidepressants.
- The selective serotonin reuptake inhibitors (SSRIs) fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft) also are used commonly by many physicians. In a double-blind placebo-controlled trial conducted by Saper et al of fluoxetine in patients with chronic daily headache and migraine, it was reported to be helpful.[5]
- Other antidepressants such as doxepin, desipramine, protriptyline, and buspirone also can be used. According to Cohen, protriptyline may be comparable in effectiveness to amitriptyline in CTTH without producing drowsiness and weight gain.
- As reported by Bendtsen et al, in one double-blind trial that compared citalopram to amitriptyline and a placebo, patients on citalopram demonstrated lower headache scores than those on placebo, but amitriptyline was significantly more effective.[6]
- Tizanidine may improve inhibitory function in the central nervous system and can provide pain relief. One recent study by Saper et al provides support for the efficacy of tizanidine in the prophylaxis of chronic daily headache.[7] Currently the use of tizanidine remains investigational in the treatment of this disorder.
- Physical therapy techniques include hot or cold applications, positioning, stretching exercises, traction, massage, ultrasound therapy, transcutaneous electrical nerve stimulation (TENS), and manipulations.
- Heat, massage, and stretching can be used to alleviate excess muscle contraction and pain.
- Cranial electrotherapy stimulation is different from TENS, is safe, and may be effective in alleviating the pain intensity of TTH. It may be considered as an alternative to long-term analgesic use.
- Psychophysiologic therapy includes reassurance, counseling, relaxation therapy, stress management programs, and biofeedback techniques. With these modalities of treatment, both frequency and severity of chronic headache may be reduced.
- In a few studies, such as that by Holroyd et al, benefits from cognitive-behavioral therapy and biofeedback therapy have been reported.[4]
- Biofeedback may be helpful in some patients when combined with medications.
- One prospective study of TTH in an elderly population suggested that relaxation therapy may be an effective intervention.
- The following various minimally invasive techniques may provide pain relief:
- Trigger point injections
- Greater or lesser occipital nerve blocks
- Auriculotemporal nerve block
- Supraorbital nerve block
- Botulinum toxin injection in the pericranial muscle
- Other alternative treatments: In one study, Biondi and Portuesi suggested that acupuncture results are difficult to assess and that acupuncture should be reserved for selected patients.[8]
Consultations
Psychiatry consultations: CTTH can mask or be associated with comorbid conditions such as depression, anxiety, or other serious emotional disorders.
Diet
Balanced meals
Activity
These nonpharmacologic methods have shown improvement of central nervous-system related symptoms:
- Regular exercise
- Adequate sleep: The patient should maintain a regular sleep schedule.
- Relaxation training[9]
Bendtsen L. Central sensitization in tension-type headache--possible pathophysiological mechanisms. Cephalalgia. Jun 2000;20(5):486-508. [Medline].
Rasmussen BK, Olesen J. Epidemiology of migraine and tension-type headache. Curr Opin Neurol. Jun 1994;7(3):264-71. [Medline].
Ulrich V, Russell MB, Jensen R. A comparison of tension-type headache in migraineurs and in non- migraineurs: a population-based study. Pain. Oct 1996;67(2-3):501-6. [Medline].
Holroyd KA, O'Donnell FJ, Stensland M, Lipchik GL, Cordingley GE, Carlson BW. Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial. JAMA. May 2 2001;285(17):2208-15. [Medline].
Saper JR, Silberstein SD, Lake AE 3rd. Double-blind trial of fluoxetine: chronic daily headache and migraine. Headache. Oct 1994;34(9):497-502. [Medline].
Bendtsen L, Jensen R. Amitriptyline reduces myofascial tenderness in patients with chronic tension-type headache. Cephalalgia. Jul 2000;20(6):603-10. [Medline].
Saper JR, Winner PK, Lake AE. An open-label dose-titration study of the efficacy and tolerability of tizanidine hydrochloride tablets in the prophylaxis of chronic daily headache. Headache. Apr 2001;41(4):357-68. [Medline].
Biondi M, Portuesi G. Tension-type headache: psychosomatic clinical assessment and treatment. Psychother Psychosom. 1994;61(1-2):41-64. [Medline].
Soderberg EI, Carlsson JY, Stener-Victorin E, Dahlof C. Subjective Well-being in Patients With Chronic Tension-type Headache: Effect of Acupuncture, Physical Training, and Relaxation Training. Clin J Pain. Jun 2011;27(5):448-56. [Medline].
Adelman LC, Adelman JU, Von Seggern R. Venlafaxine extended release (XR) for the prophylaxis of migraine and tension-type headache: A retrospective study in a clinical setting. Headache. Jul-Aug 2000;40(7):572-80. [Medline].
Altura BM, Altura BT. Tension headaches and muscle tension: is there a role for magnesium?. Med Hypotheses. Dec 2001;57(6):705-13. [Medline].
Arena JG, Hightower NE, Chong GC. Relaxation therapy for tension headache in the elderly: a prospective study. Psychol Aging. Mar 1988;3(1):96-8. [Medline].
Ashina M, Bendtsen L, Jensen R. Plasma levels of calcitonin gene-related peptide in chronic tension- type headache. Neurology. Nov 14 2000;55(9):1335-40. [Medline].
Ashina M, Bendtsen L, Jensen R. Plasma levels of substance P, neuropeptide Y and vasoactive intestinal polypeptide in patients with chronic tension-type headache. Pain. Dec 1999;83(3):541-7. [Medline].
Ashina M, Bendtsen L, Jensen R. Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache. Brain. Sep 1999;122 ( Pt 9):1629-35. [Medline].
Bendtsen L, Jensen R, Olesen J. A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. J Neurol Neurosurg Psychiatry. Sep 1996;61(3):285-90. [Medline].
Benoliel R, Sharav Y. Craniofacial pain of myofascial origin: temporomandibular pain & tension-type headache. Compend Contin Educ Dent. Jul 1998;19(7):701-4, 706, 708-10 passim; quiz 722. [Medline].
Borgeat F, Elie R, Larouche LM. Pain response to voluntary muscle tension increases and biofeedback efficacy in tension headache. Headache. Oct 1985;25(7):387-91. [Medline].
Cohen GL. Protriptyline, chronic tension-type headaches, and weight loss in women. Headache. Jul-Aug 1997;37(7):433-6. [Medline].
Diamond S, Balm TK, Freitag FG. Ibuprofen plus caffeine in the treatment of tension-type headache. Clin Pharmacol Ther. Sep 2000;68(3):312-9. [Medline].
Friedman AP. Assessment of Fiorinal with Codeine in the treatment of tension headache. Clin Ther. 1986;8(6):703-21. [Medline].
Friedman AP. Characteristics of tension headache: a profile of 1,420 cases. Psychosomatics. Jul 1979;20(7):451-7, 461. [Medline].
Gerwin RD. Chronic daily headache. N Engl J Med. May 4 2006;354(18):1958; author reply 1958. [Medline].
Granella F, D'Alessandro R, Manzoni GC, Cerbo R, Colucci D'Amato C, Pini LA, et al. International Headache Society classification: interobserver reliability in the diagnosis of primary headaches. Cephalalgia. Feb 1994;14(1):16-20. [Medline].
Jensen R. Pathophysiological mechanisms of tension-type headache: a review of epidemiological and experimental studies. Cephalalgia. Jul 1999;19(6):602-21. [Medline].
Jensen R. Tension-type Headache. Curr Treat Options Neurol. Mar 2001;3(2):169-180. [Medline].
Jensen R, Olesen J. Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia. May 1996;16(3):175-82; discussion 138-9. [Medline].
Jensen R, Olesen J. Tension-type headache: an update on mechanisms and treatment. Curr Opin Neurol. Jun 2000;13(3):285-9. [Medline].
Kunkel RS. Muscle contraction (tension) headache. Clin J Pain. 1989;5(1):39-44. [Medline].
Lance JW. Headache. Ann Neurol. Jul 1981;10(1):1-10. [Medline].
Lancet. Biofeedback and tension headache. Lancet. Oct 25 1980;2(8200):898-9. [Medline].
Langemark M, Olesen J. Pericranial tenderness in tension headache. A blind, controlled study. Cephalalgia. Dec 1987;7(4):249-55. [Medline].
Langemark M, Olesen J. Sulpiride and paroxetine in the treatment of chronic tension-type headache. An explanatory double-blind trial. Headache. Jan 1994;34(1):20-4. [Medline].
Leistad RB, Sand T, Westgaard RH. Stress-induced pain and muscle activity in patients with migraine and tension-type headache. Cephalalgia. Jan 2006;26(1):64-73. [Medline].
Lipchik GL, Holroyd KA, O'Donnell FJ, Cordingley GE, Waller S, Labus J, et al. Exteroceptive suppression periods and pericranial muscle tenderness in chronic tension-type headache: effects of psychopathology, chronicity and disability. Cephalalgia. Sep 2000;20(7):638-46. [Medline].
Marks DR, Rapoport AM. Practical evaluation and diagnosis of headache. Semin Neurol. 1997;17(4):307-12. [Medline].
Murros K, Kataja M, Hedman C. Modified-release formulation of tizanidine in chronic tension-type headache. Headache. Sep 2000;40(8):633-7. [Medline].
Myers DE, Shaikh Z, Zullo TG. Hypoalgesic effect of caffeine in experimental ischemic muscle contraction pain. Headache. Nov-Dec 1997;37(10):654-8. [Medline].
Nakashima K, Tumura R, Wang Y. Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. Headache. Sep 1994;34(8):455-7. [Medline].
Nuechterlein KH, Holroyd JC. Biofeedback in the treatment of tension headache. Current status. Arch Gen Psychiatry. Aug 1980;37(8):866-73. [Medline].
Olesen J. Clinical and pathophysiological observations in migraine and tension- type headache explained by integration of vascular, supraspinal and myofascial inputs. Pain. Aug 1991;46(2):125-32. [Medline].
Peterson AL, Talcott GW, Kelleher WJ. Site specificity of pain and tension in tension-type headaches. Headache. Feb 1995;35(2):89-92. [Medline].
Porta M. A comparative trial of botulinum toxin type a and methylprednisolone for the treatment of tension-type headache. Curr Rev Pain. 2000;4(1):31-5. [Medline].
Rasmussen BK. Migraine and tension-type headache in a general population: precipitating factors, female hormones, sleep pattern and relation to lifestyle. Pain. Apr 1993;53(1):65-72. [Medline].
Rasmussen BK, Jensen R, Schroll M. Epidemiology of headache in a general population--a prevalence study. J Clin Epidemiol. 1991;44(11):1147-57. [Medline].
Redillas C, Solomon S. Prophylactic pharmacological treatment of chronic daily headache. Headache. Feb 2000;40(2):83-102. [Medline].
Rollnik JD, Karst M, Fink M. Coping strategies in episodic and chronic tension-type headache. Headache. Mar 2001;41(3):297-302. [Medline].
Rossi LN, Cortinovis I, Menegazzo L. Classification criteria and distinction between migraine and tension- type headache in children. Dev Med Child Neurol. Jan 2001;43(1):45-51. [Medline].
Schachtel BP, Furey SA, Thoden WR. Nonprescription ibuprofen and acetaminophen in the treatment of tension- type headache. J Clin Pharmacol. Dec 1996;36(12):1120-5. [Medline].
Silberstein SD. Advances in understanding the pathophysiology of headache. Neurology. Mar 1992;42(3 Suppl 2):6-10. [Medline].
Silberstein SD. Tension-type and chronic daily headache. Neurology. Sep 1993;43(9):1644-9. [Medline].
Silberstein SD. Tension-type headaches. Headache. Sep 1994;34(8):S2-7. [Medline].
Silberstein SD, Lipton RB. Chronic daily headache. Curr Opin Neurol. Jun 2000;13(3):277-83. [Medline].
Simons DG, Mense S. Understanding and measurement of muscle tone as related to clinical muscle pain. Pain. Mar 1998;75(1):1-17. [Medline].
Solomon S. Diagnosis of primary headache disorders. Validity of the International Headache Society criteria in clinical practice. Neurol Clin. Feb 1997;15(1):15-26. [Medline].
Solomon S, Elkind A, Freitag F. Safety and effectiveness of cranial electrotherapy in the treatment of tension headache. Headache. Jul 1989;29(7):445-50. [Medline].
Stewart WF, Shechter A, Rasmussen BK. Migraine prevalence. A review of population-based studies. Neurology. Jun 1994;44(6 Suppl 4):S17-23. [Medline].
Sutton EP, Belar CD. Tension headache patients versus controls: a study of EMG parameters. Headache. May 1982;22(3):133-6. [Medline].
Walker Z, Walker RW, Robertson MM, Stansfeld S. Antidepressant treatment of chronic tension-type headache: a comparison between fluoxetine and desipramine. Headache. Jul 1998;38(7):523-8. [Medline].
Wheeler AH. Botulinum toxin A, adjunctive therapy for refractory headaches associated with pericranial muscle tension. Headache. Jun 1998;38(6):468-71. [Medline].
White AR, Resch KL, Chan JC. Acupuncture for episodic tension-type headache: a multicentre randomized controlled trial. Cephalalgia. Sep 2000;20(7):632-7. [Medline].
Wittrock DA. The comparison of individuals with tension-type headache and headache- free controls on frontal EMG levels: a meta-analysis. Headache. Jul-Aug 1997;37(7):424-32. [Medline].
Wober-Bingol C, Wober C, Karwautz A. Tension-type headache in different age groups at two headache centers. Pain. Sep 1996;67(1):53-8. [Medline].
Zagami AS. Pathophysiology of migraine and tension-type headache. Curr Opin Neurol. Jun 1994;7(3):272-7. [Medline].
Ziegler DK. Tension headache. Med Clin North Am. May 1978;62(3):495-505. [Medline].
Zissis N, Harmoussi S, Vlaikidis N. A randomized, double-blind, placebo-controlled study of venlafaxine XR in out-patients with tension-type headache. Cephalalgia. Mar 7 2007;[Medline].
Zwart JA, Bovim G, Sand T. Tension headache: botulinum toxin paralysis of temporal muscles. Headache. Sep 1994;34(8):458-62. [Medline].

