eMedicine Specialties > Neurology > Headache and Pain

Cervical Spondylosis, Diagnosis and Management: Follow-up

Author: Sandeep S Rana, MD, Clinical Associate Professor of Neurology, Drexel University College of Medicine
Contributor Information and Disclosures

Updated: Aug 14, 2009

Follow-up

Patient Education

For excellent patient education resources, visit eMedicine's Back, Ribs, Neck, and Head Center. In addition, see eMedicine's patient education articles Vertebral Compression Fracture and Neck Strain.

Miscellaneous

Medicolegal Pitfalls

  • The role of cervical spondylosis in postautomobile accident cervical whiplash syndrome has been a controversial medicolegal area.
  • In 1973, Verbiest warned clinicians to be wary of patients who present after minor trauma with symptoms attributable to cervical spondylosis, especially when legal and/or compensatory matters were involved.
  • In one series of 648 patients with ruptured cervical disks, only one patient was noted to experience a typical hyperextension injury as a result of a rear-end car collision.54
  • Repetitive trauma has been implicated (eg, in those carrying baskets on their heads), but the cause-and-effect relationship for auto accidents or other infrequently occurring trauma has not been demonstrated.

Special Concerns

Cervical diskography is a controversial tool used to assess patients with nonradicular or nonmyelopathic symptoms (eg, neck pain and suboccipital pain attributable to cervical spondylosis). It is particularly controversial because some authorities claim that diskography is a useful tool, while others remain skeptical because of a high rate of false-positive results.

  • The technique involves the injection of a small amount of contrast into the disk space. A positive study result occurs when a patient's symptoms are reproduced by the injection. Some authors also use relief of the symptoms (elicited by local injection of anesthetic) as corroborative evidence of diskogenic pain. The morphology of the disk after contrast injection is important to some authorities, while others discount it as a meaningless entity.
  • Regardless, most advocates recommend it as a test of final resort once MRI or myelography results are demonstrated to be within normal limits.
  • In theory, the test can localize the pathologic disk responsible for a patient's symptoms. One study reported that 70% of patients who underwent surgical intervention based on diskography studies experienced excellent or good results.55

 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors Eli M Baron, MD and William F Young, MD to the development and writing of this article.



More on Cervical Spondylosis, Diagnosis and Management

Overview: Cervical Spondylosis, Diagnosis and Management
Differential Diagnoses & Workup: Cervical Spondylosis, Diagnosis and Management
Treatment & Medication: Cervical Spondylosis, Diagnosis and Management
Follow-up: Cervical Spondylosis, Diagnosis and Management
Multimedia: Cervical Spondylosis, Diagnosis and Management
References

References

  1. Parke WW. Correlative anatomy of cervical spondylotic myelopathy. Spine (Phila Pa 1976). Jul 1988;13(7):831-7. [Medline].

  2. McCormack BM, Weinstein PR. Cervical spondylosis. An update. West J Med. Jul-Aug 1996;165(1-2):43-51. [Medline].

  3. Wilkinson M. The morbid anatomy of cervical spondylosis and myelopathy. Brain. Dec 1960;83:589-617. [Medline].

  4. Hoff JT, Wilson CB. The pathophysiology of cervical spondylotic radiculopathy and myelopathy. Clin Neurosurg. 1977;24:474-87. [Medline].

  5. Rosomoff HL, Fishbain D, Rosomoff RS. Chronic cervical pain: radiculopathy or brachialgia. Noninterventional treatment. Spine (Phila Pa 1976). Oct 1992;17(10 Suppl):S362-6. [Medline].

  6. Emery SE. Cervical spondylotic myelopathy: diagnosis and treatment. J Am Acad Orthop Surg. Nov-Dec 2001;9(6):376-88. [Medline].

  7. Fehlings MG, Skaf G. A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury. Spine (Phila Pa 1976). Dec 15 1998;23(24):2730-7. [Medline].

  8. Young WF. Cervical spondylotic myelopathy: a common cause of spinal cord dysfunction in older persons. Am Fam Physician. Sep 1 2000;62(5):1064-70, 1073. [Medline].

  9. McCormick WE, Steinmetz MP, Benzel EC. Cervical spondylotic myelopathy: make the difficult diagnosis, then refer for surgery. Cleve Clin J Med. Oct 2003;70(10):899-904. [Medline].

  10. Young WF, Weaver M, Mishra B. Surgical outcome in patients with coexisting multiple sclerosis and spondylosis. Acta Neurol Scand. Aug 1999;100(2):84-7. [Medline].

  11. al-Mefty O, Harkey HL, Marawi I, et al. Experimental chronic compressive cervical myelopathy. J Neurosurg. Oct 1993;79(4):550-61. [Medline].

  12. Henderson FC, Geddes JF, Vaccaro AR, Woodard E, Berry KJ, Benzel EC. Stretch-associated injury in cervical spondylotic myelopathy: new concept and review. Neurosurgery. May 2005;56(5):1101-13; discussion 1101-13. [Medline].

  13. Moore AP, Blumhardt LD. A prospective survey of the causes of non-traumatic spastic paraparesis and tetraparesis in 585 patients. Spinal Cord. Jun 1997;35(6):361-7. [Medline].

  14. Holt S, Yates PO. Cervical spondylosis and nerve root lesions. Incidence at routine necropsy. J Bone Joint Surg Br. Aug 1966;48(3):407-23. [Medline].

  15. Rahim KA, Stambough JL. Radiographic evaluation of the degenerative cervical spine. Orthop Clin North Am. Jul 1992;23(3):395-403. [Medline].

  16. Heller JG. The syndromes of degenerative cervical disease. Orthop Clin North Am. Jul 1992;23(3):381-94. [Medline].

  17. Ellenberg MR, Honet JC, Treanor WJ. Cervical radiculopathy. Arch Phys Med Rehabil. Mar 1994;75(3):342-52. [Medline].

  18. Stoffman MR, Roberts MS, King JT Jr. Cervical spondylotic myelopathy, depression, and anxiety: a cohort analysis of 89 patients. Neurosurgery. Aug 2005;57(2):307-13; discussion 307-13. [Medline].

  19. Schneider RC, Cherry G, Pantek H. The syndrome of acute central cervical spinal cord injury; with special reference to the mechanisms involved in hyperextension injuries of cervical spine. J Neurosurg. Nov 1954;11(6):546-77. [Medline].

  20. Kaye JJ, Dunn AW. Cervical spondylotic dysphagia. South Med J. May 1977;70(5):613-4. [Medline].

  21. Umerah BC, Mukherjee BK, Ibekwe O. Cervical spondylosis and dysphagia. J Laryngol Otol. Nov 1981;95(11):1179-83. [Medline].

  22. Sobol SM, Rigual NR. Anterolateral extrapharyngeal approach for cervical osteophyte-induced dysphagia. Literature review. Ann Otol Rhinol Laryngol. Sep-Oct 1984;93(5 Pt 1):498-504. [Medline].

  23. Farooqi NA, Doran M, Buxton N. Cervical osteophytes: a cause of potentially life-threatening laryngeal spasms. Case report. J Neurosurg Spine. May 2006;4(5):419-20. [Medline].

  24. Kanbay M, Selcuk H, Yilmaz U. Dysphagia caused by cervical osteophytes: a rare case. J Am Geriatr Soc. Jul 2006;54(7):1147-8. [Medline].

  25. Teresi LM, Lufkin RB, Reicher MA, et al. Asymptomatic degenerative disk disease and spondylosis of the cervical spine: MR imaging. Radiology. Jul 1987;164(1):83-8. [Medline].

  26. Brown BM, Schwartz RH, Frank E, Blank NK. Preoperative evaluation of cervical radiculopathy and myelopathy by surface-coil MR imaging. AJR Am J Roentgenol. Dec 1988;151(6):1205-12. [Medline].

  27. Alexander JT. Natural history and nonoperative management of cervical spondylosis. In: Menezes AH, Sonntag VKH, et al. Principles of Spinal Surgery. Vol 1. 1996:547-557.

  28. Penning L, Wilmink JT, van Woerden HH, Knol E. CT myelographic findings in degenerative disorders of the cervical spine: clinical significance. AJR Am J Roentgenol. Apr 1986;146(4):793-801. [Medline].

  29. Yamazaki T, Suzuki K, Yanaka K, Matsumura A. Dynamic computed tomography myelography for the investigation of cervical degenerative disease. Neurol Med Chir (Tokyo). Apr 2006;46(4):210-5; discussion 215-6. [Medline].

  30. Iwabuchi M, Kikuchi S, Sato K. Pathoanatomic investigation of cervical spondylotic myelopathy. Fukushima J Med Sci. Dec 2004;50(2):47-54. [Medline].

  31. Gore DR, Sepic SB, Gardner GM, Murray MP. Neck pain: a long-term follow-up of 205 patients. Spine (Phila Pa 1976). Jan-Feb 1987;12(1):1-5. [Medline].

  32. AGS Panel on Persistent Pain in Older Persons. The management of of persistent pain in older persons. J Am Geriatr Soc. 2002;50(Suppl 6):S205-S224.

  33. Swezey RL, Swezey AM, Warner K. Efficacy of home cervical traction therapy. Am J Phys Med Rehabil. Jan-Feb 1999;78(1):30-2. [Medline].

  34. Kaiser MG, Haid RW, Subach BR, Barnes B, Rodts GE Jr. Anterior cervical plating enhances arthrodesis after discectomy and fusion with cortical allograft. Neurosurgery. Feb-2002;50:229-236.

  35. Baskin DS, Ryan P, Sonnta V, Westmark R, Wedmayer MA. A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogentic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine. 2003;28:1219-1225.

  36. Rowland LP. Surgical treatment of cervical spondylotic myelopathy: time for a controlled trial. Neurology. Jan 1992;42(1):5-13. [Medline].

  37. Nurick S. The natural history and the results of surgical treatment of the spinal cord disorder associated with cervical spondylosis. Brain. 1972;95(1):101-8. [Medline].

  38. Fouyas IP, Statham PF, Sandercock PA. Cochrane review on the role of surgery in cervical spondylotic radiculomyelopathy. Spine (Phila Pa 1976). Apr 1 2002;27(7):736-47. [Medline].

  39. Kadanka Z, Mares M, Bednaník J, et al. Approaches to spondylotic cervical myelopathy: conservative versus surgical results in a 3-year follow-up study. Spine (Phila Pa 1976). Oct 15 2002;27(20):2205-10; discussion 2210-1. [Medline].

  40. Sampath P, Bendebba M, Davis JD, Ducker TB. Outcome of patients treated for cervical myelopathy. A prospective, multicenter study with independent clinical review. Spine (Phila Pa 1976). Mar 15 2000;25(6):670-6. [Medline].

  41. Ma X, Zhao XF, Zhao YB. [A clinical study on different decompression methods in cervical spondylosis]. Zhonghua Wai Ke Za Zhi. Apr 15 2009;47(8):607-9. [Medline].

  42. Lee JY, Sharan A, Baron EM, et al. Quantitative prediction of spinal cord drift after cervical laminectomy and arthrodesis. Spine (Phila Pa 1976). Jul 15 2006;31(16):1795-8. [Medline].

  43. Wang MY, Shah S, Green BA. Clinical outcomes following cervical laminoplasty for 204 patients with cervical spondylotic myelopathy. Surg Neurol. Dec 2004;62(6):487-92; discussion 492-3. [Medline].

  44. Kaminsky SB, Clark CR, Traynelis VC. Operative treatment of cervical spondylotic myelopathy and radiculopathy. A comparison of laminectomy and laminoplasty at five year average follow-up. Iowa Orthop J. 2004;24:95-105. [Medline].

  45. Grob D. Surgery in the degenerative cervical spine. Spine (Phila Pa 1976). Dec 15 1998;23(24):2674-83. [Medline].

  46. Kumar VG, Rea GL, Mervis LJ, McGregor JM. Cervical spondylotic myelopathy: functional and radiographic long-term outcome after laminectomy and posterior fusion. Neurosurgery. Apr 1999;44(4):771-7; discussion 777-8. [Medline].

  47. Houten JK, Cooper PR. Laminectomy and posterior cervical plating for multilevel cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament: effects on cervical alignment, spinal cord compression, and neurological outcome. Neurosurgery. May 2003;52(5):1081-7; discussion 1087-8. [Medline].

  48. Huang RC, Girardi FP, Poynton AR, Cammisa Jr FP. Treatment of multilevel cervical spondylotic myeloradiculopathy with posterior decompression and fusion with lateral mass plate fixation and local bone graft. J Spinal Disord Tech. Apr 2003;16(2):123-9. [Medline].

  49. Chagas H, Domingues F, Aversa A, Vidal Fonseca AL, de Souza JM. Cervical spondylotic myelopathy: 10 years of prospective outcome analysis of anterior decompression and fusion. Surg Neurol. 2005;64 Suppl 1:S1:30-5; discussion S1:35-6. [Medline].

  50. Chibbaro S, Benvenuti L, Carnesecchi S, et al. Anterior cervical corpectomy for cervical spondylotic myelopathy: experience and surgical results in a series of 70 consecutive patients. J Clin Neurosci. Feb 2006;13(2):233-8. [Medline].

  51. Macdonald RL, Fehlings MG, Tator CH, et al. Multilevel anterior cervical corpectomy and fibular allograft fusion for cervical myelopathy. J Neurosurg. Jun 1997;86(6):990-7. [Medline].

  52. Santiago P, Fessler RG. Minimally Invasive Surgery for the Management of cervical spondylosis. Neurosurgery. Jan-2007;60:S1-160-165.

  53. Razack N, Greenberg J, Green BA. Surgery for cervical myelopathy in geriatric patients. Spinal Cord. Sep 1998;36(9):629-32. [Medline].

  54. Murphey F, Simmons JC, Brunson B. Chapter 2. Ruptured cervical discs, 1939 to 1972. Clin Neurosurg. 1973;20:9-17. [Medline].

  55. Whitecloud TS 3rd, Seago RA. Cervical discogenic syndrome. Results of operative intervention in patients with positive discography. Spine (Phila Pa 1976). May 1987;12(4):313-6. [Medline].

  56. Bracken MB, Shepard MJ, Collins WF Jr, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg. Jan 1992;76(1):23-31. [Medline].

  57. Chesnut RM, Abitbol JJ, Garfin SR. Surgical management of cervical radiculopathy. Indication, techniques, and results. Orthop Clin North Am. Jul 1992;23(3):461-74. [Medline].

  58. Chiles BW 3rd, Leonard MA, Choudhri HF, Cooper PR. Cervical spondylotic myelopathy: patterns of neurological deficit and recovery after anterior cervical decompression. Neurosurgery. Apr 1999;44(4):762-9; discussion 769-70. [Medline].

  59. Clarke E, Robinson PK. Cervical myelopathy: a complication of cervical spondylosis. Brain. Sep 1956;79(3):483-510. [Medline].

  60. Clements DH, O'Leary PF. Anterior cervical discectomy and fusion. Spine (Phila Pa 1976). Oct 1990;15(10):1023-5. [Medline].

  61. Connor PM, Darden BV 2nd. Cervical discography complications and clinical efficacy. Spine (Phila Pa 1976). Oct 15 1993;18(14):2035-8. [Medline].

  62. Cull R, Whittle I. The nervous system. In: Munro J, Edwards CS. Macleod's Clinical Examination. 1995:201-256.

  63. Denno JJ, Meadows GR. Early diagnosis of cervical spondylotic myelopathy. A useful clinical sign. Spine (Phila Pa 1976). Dec 1991;16(12):1353-5. [Medline].

  64. Dillin W, Booth R, Cuckler J, Balderston R, Simeone F, Rothman R. Cervical radiculopathy. A review. Spine (Phila Pa 1976). Dec 1986;11(10):988-91. [Medline].

  65. Dillin W, Uppal GS. Analysis of medications used in the treatment of cervical disk degeneration. Orthop Clin North Am. Jul 1992;23(3):421-33. [Medline].

  66. Durufle A, Petrilli S, Le Guiet JL, et al. Cervical spondylotic myelopathy in athetoid cerebral palsy patients: about five cases. Joint Bone Spine. May 2005;72(3):270-4. [Medline].

  67. Ebara S, Yonenobu K, Fujiwara K, Yamashita K, Ono K. Myelopathy hand characterized by muscle wasting. A different type of myelopathy hand in patients with cervical spondylosis. Spine (Phila Pa 1976). Jul 1988;13(7):785-91. [Medline].

  68. Firooznia H, Ahn JH, Rafii M, Ragnarsson KT. Sudden quadriplegia after a minor trauma. The role of preexisting spinal stenosis. Surg Neurol. Feb 1985;23(2):165-8. [Medline].

  69. Goodridge AE, Feasby TE, Ebers GC, Brown WF, Rice GP. Hand wasting due to mid-cervical spinal cord compression. Can J Neurol Sci. Aug 1987;14(3):309-11. [Medline].

  70. Haerer AF. Examination in cases of suspected hysteria and malingering. In: DeJong's The Neurologic Examination. 5th ed. 1992:744.

  71. Haldeman S, Kohlbeck FJ, McGregor M. Risk factors and precipitating neck movements causing vertebrobasilar artery dissection after cervical trauma and spinal manipulation. Spine (Phila Pa 1976). Apr 15 1999;24(8):785-94. [Medline].

  72. Irvine DH, Foster JB, Newell DJ, Klukvin BN. Prevalence of cervical spondylosis in a general practice. Lancet. May 22 1965;14:1089-92. [Medline].

  73. Jumah KB, Nyame PK. Relationship between load carrying on the head and cervical spondylosis in Ghanaians. West Afr J Med. Jul-Sep 1994;13(3):181-2. [Medline].

  74. Kaiser JA, Holland BA. Imaging of the cervical spine. Spine (Phila Pa 1976). Dec 15 1998;23(24):2701-12. [Medline].

  75. LaBan MM, Taylor RS. Manipulation: an objective analysis of the literature. Orthop Clin North Am. Jul 1992;23(3):451-9. [Medline].

  76. Lam M. Headache. In: Adler SN, et al. A Pocket manual of Differential Diagnosis. 1994:303-304.

  77. LaRocca H. Cervical spondylotic myelopathy: natural history. Spine (Phila Pa 1976). Jul 1988;13(7):854-5. [Medline].

  78. Lees F, Turner J. Natural history and prognosis of cervical spondylosis. BMJ. 1963;2:1603.

  79. Nakano KK. Neck pain. In: Kelley WN, Harris ED, Ruddy S, Sledge CB. Textbook of Rheumatology. 1985:471-490.

  80. Ono K, Ebara S, Fuji T, Yonenobu K, Fujiwara K, Yamashita K. Myelopathy hand. New clinical signs of cervical cord damage. J Bone Joint Surg Br. Mar 1987;69(2):215-9. [Medline].

  81. Papadopoulos SM, Hoff JT. Anatomical treatment of cervical spondylosis. Clin Neurosurg. 1994;41:270-85. [Medline].

  82. Phillips DG. Surgical treatment of myelopathy with cervical spondylosis. J Neurol Neurosurg Psychiatry. Oct 1973;36(5):879-84. [Medline].

  83. Raynor RB, Pugh J, Shapiro I. Cervical facetectomy and its effect on spine strength. J Neurosurg. Aug 1985;63(2):278-82. [Medline].

  84. Robinson R, Smith G. Anterolateral cervical disc removal and interbody fusion for cervical disc syndrome. Bull Johns Hopkins Hosp. 1955;96:223.

  85. Saunders R. Corpectomy for cervical spondylotic myelopathy. In: Menezes AH, Sonntag VH, et al. Principles of Spinal Surgery. Vol. 1. 1996:559-569.

  86. Schellhas KP, Smith MD, Gundry CR, Pollei SR. Cervical discogenic pain. Prospective correlation of magnetic resonance imaging and discography in asymptomatic subjects and pain sufferers. Spine (Phila Pa 1976). Feb 1 1996;21(3):300-11; discussion 311-2. [Medline].

  87. Tan JC, Nordin M. Role of physical therapy in the treatment of cervical disk disease. Orthop Clin North Am. Jul 1992;23(3):435-49. [Medline].

  88. Verbiest H. Chapter 23. The management of cervical spondylosis. Clin Neurosurg. 1973;20:262-94. [Medline].

  89. Viikari-Juntura E, Porras M, Laasonen EM. Validity of clinical tests in the diagnosis of root compression in cervical disc disease. Spine (Phila Pa 1976). Mar 1989;14(3):253-7. [Medline].

  90. Watson JC, Broaddus WC, Smith MM, Kubal WS. Hyperactive pectoralis reflex as an indicator of upper cervical spinal cord compression. Report of 15 cases. J Neurosurg. Jan 1997;86(1):159-61. [Medline].

  91. Yoo K, Origitano TC. Familial cervical spondylosis. Case report. J Neurosurg. Jul 1998;89(1):139-41. [Medline].

  92. Yoss RE, Corbin KB, Maccarty CS, Love JG. Significance of symptoms and signs in localization of involved root in cervical disk protrusion. Neurology. Oct 1957;7(10):673-83. [Medline].

Further Reading

Keywords

cervical spondylosis, cervical spondylosis treatment, cervical degenerative joint disease, cervical spine, cervical degenerative disk disease, cervical osteoarthritis, cervical spondylotic myelopathy, CSM, disk degeneration, degenerative cervical disease, osteophytic bars, cervical radiculopathy, neck pain, shoulder pain, cervicalgia, chronic suboccipital headache, paresthesias, pseudoangina, breast pain, nontraumatic paraparesis, nontraumatic tetraparesis, numbness, clumsy hands, loss of manual dexterity, difficulty with writing, central cord syndrome, Tinel sign, Spurling sign, Babinski sign, Hoffman sign, pectoralis muscle reflex, spastic gait, Lhermitte sign

Contributor Information and Disclosures

Author

Sandeep S Rana, MD, Clinical Associate Professor of Neurology, Drexel University College of Medicine
Sandeep S Rana, MD is a member of the following medical societies: American Academy of Neurology, American Society of Neuroimaging, and Pennsylvania Medical Society
Disclosure: Nothing to disclose.

Medical Editor

William J Nowack, MD, Associate Professor, Epilepsy Center, Department of Neurology, University of Kansas Medical Center
William J Nowack, MD is a member of the following medical societies: American Academy of Neurology, American Clinical Neurophysiology Society, American Epilepsy Society, American Medical Electroencephalographic Association, American Medical Informatics Association, and Biomedical Engineering Society
Disclosure: Nothing to disclose.

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Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

James H Halsey, MD, Professor, Department of Neurology, University of Alabama Medical Center
James H Halsey, MD is a member of the following medical societies: American Academy of Neurology, American Heart Association, American Medical Association, American Neurological Association, American Society of Neuroimaging, Medical Association of the State of Alabama, New York Academy of Sciences, Pan American Medical Association, Sigma Xi, Society for Neuroscience, and Southern Medical Association
Disclosure: Nothing to disclose.

CME Editor

Selim R Benbadis, MD, Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, University of South Florida School of Medicine, Tampa General Hospital
Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Howard A Crystal, MD, Professor, Departments of Neurology and Pathology, State University of New York Downstate; Consulting Staff, Department of Neurology, University Hospital and Kings County Hospital Center
Howard A Crystal, MD is a member of the following medical societies: American Academy of Neurology and American Neurological Association
Disclosure: Medivations Honoraria Consulting

 
 
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