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Diffuse Sclerosis Medication

  • Author: Robert Stanley Rust, Jr, MD, MA; Chief Editor: Niranjan N Singh, MD, DM  more...
 
Updated: Apr 14, 2016
 

Medication Summary

The use of methylprednisolone, its indications, and its possible effects have been reviewed in Treatment. Other corticosteroids or intravenous gamma globulin (IVIG) possibly would also prove beneficial during the acute phase of presentation, but no information exists at present upon which to base any but the most general statements concerning these approaches. Whether intravenous corticosteroid therapy should be followed by an oral taper is unclear, although in most instances of recognized Schilderlike disease, such a taper is generally undertaken. No information exists concerning the appropriate length of such a taper or the influence of such a taper on outcome. No information exists concerning the efficacy of immunomodulatory therapy in Schilder disease as defined by the strict 1912-type criteria posed by CM Poser.

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Corticosteroids

Class Summary

Have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the body's immune response to diverse stimuli.

Methylprednisolone (Depo-Medrol, Solu-Medrol, Medrol)

 

The initial dose should be administered under close supervision because rare instances of anaphylaxis after initial dose have been reported.

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Contributor Information and Disclosures
Author

Robert Stanley Rust, Jr, MD, MA Thomas E Worrell Jr Professor of Epileptology and Neurology, Co-Director of FE Dreifuss Child Neurology and Epilepsy Clinics, Director, Child Neurology, University of Virginia School of Medicine; Chair-Elect, Child Neurology Section, American Academy of Neurology

Robert Stanley Rust, Jr, MD, MA is a member of the following medical societies: Child Neurology Society, Society for Pediatric Research, American Headache Society, International Child Neurology Association, American Academy of Neurology, American Epilepsy Society, American Neurological Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

Niranjan N Singh, MD, DM Associate Professor of Neurology, University of Missouri-Columbia School of Medicine

Niranjan N Singh, MD, DM is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Headache Society

Disclosure: Nothing to disclose.

Additional Contributors

William J Nowack, MD Associate Professor, Epilepsy Center, Department of Neurology, University of Kansas Medical Center

William J Nowack, MD is a member of the following medical societies: American Academy of Neurology, Biomedical Engineering Society, American Clinical Neurophysiology Society, American Epilepsy Society, EEG and Clinical Neuroscience Society, American Medical Informatics Association

Disclosure: Nothing to disclose.

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