Spinal Cord Trauma and Related Diseases Medication
- Author: Francisco de Assis Aquino Gondim, MD, MSc, PhD, FAAN; Chief Editor: Stephen A Berman, MD, PhD, MBA more...
The goals of pharmacotherapy are to reduce morbidity and prevent complications.
Have both anti-inflammatory (glucocorticoid) and salt-retaining (mineralocorticoid) properties. Glucocorticoids have profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli.
A multicenter study demonstrated improved neurologic outcome, possibly by preventing the cascade of inflammatory events following SCI.
Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.
For various inflammatory diseases. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.
For spinal tumors causing mass effect, a few anecdotal protocols use dexamethasone in high doses of 10-100 mg IV followed by 6-10 mg IV q6h for 24 h, potentially tapered IV or PO over 1-3 wk.
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