Leptomeningeal Carcinomatosis Differential Diagnoses

  • Author: R Andrew Sewell, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA   more...
 
Updated: Feb 3, 2012
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

R Andrew Sewell, MD  Associate Research Scientist in Psychiatry and Mental Illness Research, Education,Veterans Affairs Connecticut Health Care System, Yale University School of Medicine

R Andrew Sewell, MD is a member of the following medical societies: American Academy of Neurology, American Headache Society, American Pain Society, and American Psychiatric Association

Disclosure: Nothing to disclose.

Coauthor(s)

Lawrence D Recht, MD  Professor of Neurology and Neurosurgery, Department of Neurology and Clinical Neurosciences, Stanford University Medical School

Lawrence D Recht, MD is a member of the following medical societies: American Academy of Neurology, American Association for Cancer Research, American Neurological Association, and Society for Neuroscience

Disclosure: Nothing to disclose.

Specialty Editor Board

Frederick M Vincent Sr, MD  Clinical Professor, Department of Neurology and Ophthalmology, Michigan State University Colleges of Human and Osteopathic Medicine

Frederick M Vincent Sr, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American College of Forensic Examiners, American College of Legal Medicine, American College of Physicians, and Michigan State Medical Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Jorge C Kattah, MD  Head, Associate Program Director, Professor, Department of Neurology, University of Illinois College of Medicine at Peoria

Jorge C Kattah, MD is a member of the following medical societies: American Academy of Neurology, American Neurological Association, and New York Academy of Sciences

Disclosure: Biogen Honoraria Consulting; Bayer Corporation Honoraria Consulting

Selim R Benbadis, MD  Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, Tampa General Hospital, University of South Florida College of Medicine

Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association

Disclosure: UCB Pharma Honoraria Speaking, consulting; Lundbeck Honoraria Speaking, consulting; Cyberonics Honoraria Speaking, consulting; Glaxo Smith Kline Honoraria Speaking, consulting; Pfizer Honoraria Speaking, consulting; Sleepmed/DigiTrace Honoraria Speaking, consulting

Chief Editor

Stephen A Berman, MD, PhD, MBA  Professor of Neurology, University of Central Florida College of Medicine

Stephen A Berman, MD, PhD, MBA is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

References

  1. Chamberlain MC. Leptomeningeal metastasis. Curr Opin Neurol. Sep 4 2009;[Medline].

  2. Gani C, Müller AC, Eckert F, Schroeder C, Bender B, Pantazis G, et al. Outcome after whole brain radiotherapy alone in intracranial leptomeningeal carcinomatosis from solid tumors. Strahlenther Onkol. Feb 2012;188(2):148-153. [Medline].

  3. Groves MD, Hess KR, Puduvalli VK, Colman H, Conrad CA, Gilbert MR. Biomarkers of disease: cerebrospinal fluid vascular endothelial growth factor (VEGF) and stromal cell derived factor (SDF)-1 levels in patients with neoplastic meningitis (NM) due to breast cancer, lung cancer and melanoma. J Neurooncol. Sep 2009;94(2):229-34. [Medline].

  4. Quijano S, López A, Manuel Sancho J, Panizo C, Debén G, Castilla C, et al. Identification of leptomeningeal disease in aggressive B-cell non-Hodgkin's lymphoma: improved sensitivity of flow cytometry. J Clin Oncol. Mar 20 2009;27(9):1462-9. [Medline].

  5. Subirá D, Serrano C, Castañón S, Gonzalo R, Illán J, Pardo J, et al. Role of flow cytometry immunophenotyping in the diagnosis of leptomeningeal carcinomatosis. Neuro Oncol. Jan 2012;14(1):43-52. [Medline]. [Full Text].

  6. Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. Feb 15 1982;49(4):759-72. [Medline].

  7. Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, et al. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol. Apr 10 2007;25(11):1350-6. [Medline].

  8. Stemmler HJ, Mengele K, Schmitt M, Harbeck N, Laessig D, Herrmann KA. Intrathecal trastuzumab (Herceptin) and methotrexate for meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer: a case report. Anticancer Drugs. Sep 2008;19(8):832-6. [Medline].

  9. Lin N, Dunn IF, Glantz M, Allison DL, Jensen R, Johnson MD, et al. Benefit of ventriculoperitoneal cerebrospinal fluid shunting and intrathecal chemotherapy in neoplastic meningitis: a retrospective, case-controlled study. J Neurosurg. Oct 2011;115(4):730-6. [Medline].

  10. Nagano T, Kotani Y, Kobayashi K, Hatakeyama Y, Hori S, Kasai D, et al. Long-term outcome after multidisciplinary approach for leptomeningeal carcinomatosis in a non-small cell lung cancer patient with poor performance status. Intern Med. 2011;50(24):3019-22. [Medline].

  11. Balm M, Hammack J. Leptomeningeal carcinomatosis: presenting features and prognostic factors. Arch Neurol. Jul 1996;53(7):626-32. [Medline].

  12. Bradley WG. Leptomeningeal metastases in primary and secondary tumors of the nervous system. In: Neurology in Clinical Practice. Stoneham, MA: Butterworth-Heinemann; 1991.

  13. Brem SS, Bierman PJ, Black P, Brem H, Chamberlain MC, Chiocca EA. Central nervous system cancers. J Natl Compr Canc Netw. May 2008;6(5):456-504. [Medline].

  14. Chamberlain MC, Kormanik PA, Glantz MJ. A comparison between ventricular and lumbar cerebrospinal fluid cytology in adult patients with leptomeningeal metastases. Neuro-oncol. Jan 2001;3(1):42-5. [Medline].

  15. Cokgor I, Friedman AH, Friedman HS. Current options for the treatment of neoplastic meningitis. J Neurooncol. Oct 2002;60(1):79-88. [Medline].

  16. Gasecki AP, Bashir RM, Foley J. Leptomeningeal carcinomatosis: a report of 3 cases and review of the literature. Eur Neurol. 1992;32(2):74-8. [Medline].

  17. Glantz MJ, Cole BF, Glantz LK, et al. Cerebrospinal fluid cytology in patients with cancer: minimizing false- negative results. Cancer. Feb 15 1998;82(4):733-9. [Medline].

  18. Grossman SA, Krabak MJ. Leptomeningeal carcinomatosis. Cancer Treat Rev. Apr 1999;25(2):103-19. [Medline].

  19. Hildebrand J. Prophylaxis and treatment of leptomeningeal carcinomatosis in solid tumors of adulthood. J Neurooncol. Jun-Jul 1998;38(2-3):193-8. [Medline].

  20. Pavlidis N. The diagnostic and therapeutic management of leptomeningeal carcinomatosis. Ann Oncol. 2004;15 Suppl 4:iv285-91. [Medline].

  21. Posner JB. Leptomeningeal metastases. In: Neurologic Complications of Cancer. Oxford, England: Oxford University Press; 1995.

  22. Recht L, Phuphanich S. Treatment of neoplastic meningitis: what is the standard of care?. Expert Rev Neurother. Jul 2004;4(4 Suppl):S11-7. [Medline].

  23. Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J. Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol. Jan 1 2008;26(1):96-105. [Medline].

  24. Soletormos G, Bach F. Cerebrospinal Fluid Cytokeratins for Diagnosis of Patients with Central Nervous System Metastases from Breast Cancer. Clinical Chemistry. 2001;47:948-950.

  25. Tetef ML, Margolin KA, Doroshow JH, et al. Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis. Cancer Chemother Pharmacol. 2000;46(1):19-26. [Medline].

  26. Wolfgang G, Marcus D, Ulrike S. LC: clinical syndrome in different primaries. J Neurooncol. Jun-Jul 1998;38(2-3):103-10. [Medline].

 
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