eMedicine Specialties > Neurology > Neuro-vascular Diseases
Basilar Artery Thrombosis: Follow-up
Updated: Aug 18, 2009
Follow-up
Further Inpatient Care
- Rehabilitation: Patients with brainstem, cerebellar, diencephalic, or occipital infarcts secondary to basilar artery occlusion have a significant degree of disability because of weakness, ataxia, swallowing difficulties, other cranial neuropathies, or a combination of all.
- Patients need training on balance and gait.
- Patients with dysphagia are at a significant risk for aspiration and pneumonia. Evaluation of these patients should be thorough and should include videofluoroscopy with modified barium swallow to assess for silent aspiration. Interventions for prevention of aspiration include compensatory strategies that include oromotor exercises; postural changes while swallowing; and facilitative strategies that include modification of bolus consistency, volume, and delivery.
- Using a patch on one eye or prisms can help diplopia.
Further Outpatient Care
- These patients need strict risk factor control to decrease the risk of stroke recurrence.
Deterrence/Prevention
- The prevention strategy depends on the cause of the basilar artery occlusion.
- Patients with a definite cardioembolic source, such as atrial fibrillation, should be treated with warfarin to maintain an INR between 2 and 3.
- The treatment of patients with basilar artery and vertebral artery atherosclerosis includes antiplatelet agents and risk factor control.
- No definite indication currently exists for long-term anticoagulation in patients with noncardioembolic stroke.
Complications
Prognosis
- Patients with acute basilar artery occlusion have a mortality rate greater than 85%, although the mortality rate may be as low as 40% in patients with recanalization.
- Good functional outcomes can be expected in as many as 24-35% of patients treated with intravenous or intra-arterial thrombolysis, respectively.
- For symptomatic patients who survive, the risk of recurrent stroke is 10-15%.
Patient Education
- For excellent patient education resources, visit eMedicine's Cholesterol Center. In addition, see eMedicine's patient education articles High Cholesterol and Cholesterol FAQs.
More on Basilar Artery Thrombosis |
| Overview: Basilar Artery Thrombosis |
| Differential Diagnoses & Workup: Basilar Artery Thrombosis |
| Treatment & Medication: Basilar Artery Thrombosis |
Follow-up: Basilar Artery Thrombosis |
| Multimedia: Basilar Artery Thrombosis |
| References |
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References
Lindsberg PJ, Soinne L, Tatlisumak T, et al. Long-term outcome after intravenous thrombolysis of basilar artery occlusion. JAMA. Oct 20 2004;292(15):1862-6. [Medline].
Devuyst G, Bogousslavsky J, Meuli R, et al. Stroke or transient ischemic attacks with basilar artery stenosis or occlusion: clinical patterns and outcome. Arch Neurol. Apr 2002;59(4):567-73. [Medline].
Davis SM, Donnan GA. Basilar artery thrombosis: recanalization is the key. Stroke. Sep 2006;37(9):2440. [Medline].
Schonewille WJ, Algra A, Serena J, Molina CA, Kappelle LJ. Outcome in patients with basilar artery occlusion treated conventionally. J Neurol Neurosurg Psychiatry. 2005;Sep;76(9):1238-41. [Medline]. [Full Text].
Arnold M, Nedeltchev K, Schroth G, et al. Clinical and radiological predictors of recanalisation and outcome of 40 patients with acute basilar artery occlusion treated with intra-arterial thrombolysis. J Neurol Neurosurg Psychiatry. Jun 2004;75(6):857-62. [Medline].
Puetz V, Sylaja PN, Coutts SB, et al. Extent of hypoattenuation on CT angiography source images predicts functional outcome in patients with basilar artery occlusion. Stroke. Sep 2008;39(9):2485-90. [Medline]. [Full Text].
Cho TH, Nighoghossian N, Tahon F, et al. Brain stem diffusion-weighted imaging lesion score: a potential marker of outcome in acute basilar artery occlusion. AJNR Am J Neuroradiol. Jan 2009;30(1):194-8. [Medline].
Kermer P, Wellmer A, Crome O, et al. Transcranial color-coded duplex sonography in suspected acute basilar artery occlusion. Ultrasound Med Biol. Mar 2006;32(3):315-20. [Medline].
Lindsberg PJ, Mattle HP. Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis. Stroke. Mar 2006;37(3):922-8. [Medline].
Yu W, Binder D, Foster-Barber A, et al. Endovascular embolectomy of acute basilar artery occlusion. Neurology. Nov 25 2003;61(10):1421-3. [Medline].
Lutsep HL, Rymer MM, Nesbit GM. Vertebrobasilar revascularization rates and outcomes in the MERCI and multi-MERCI trials. J Stroke Cerebrovasc Dis. Mar-Apr 2008;17(2):55-7. [Medline].
Pfefferkorn T, Mayer TE, Opherk C, et al. Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients. Stroke. May 2008;39(5):1496-500. [Medline]. [Full Text].
Aichner FT, Felber SR, Birbamer GG. Magnetic resonance imaging and magnetic resonance angiography of vertebrobasilar dolichoectasia. Cerebrovasc Dis. 1993;3:280-284.
Amarenco P, Duyckaerts C, Tzourio C, et al. The prevalence of ulcerated plaques in the aortic arch in patients with stroke. N Engl J Med. Jan 23 1992;326(4):221-5. [Medline].
Antiplatelet Trialists' Collaboration. Secondary prevention of vascular disease by prolonged antiplatelet treatment. Br Med J (Clin Res Ed). Jan 30 1988;296(6618):320-31. [Medline].
Archer CR, Horenstein S. Basilar artery occlusion: clinical and radiological correlation. Stroke. May-Jun 1977;8(3):383-90. [Medline].
Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. Stroke. Nov-Dec 1981;12(6):723-5. [Medline].
Bergui M, Stura G, Daniele D, et al. Mechanical thrombolysis in ischemic stroke attributable to basilar artery occlusion as first-line treatment. Stroke. Jan 2006;37(1):145-50. [Medline].
Biller J, Yuh WT, Mitchell GW, et al. Early diagnosis of basilar artery occlusion using magnetic resonance imaging. Stroke. Mar 1988;19(3):297-306. [Medline].
Bockenheimer S, Reinhuber F, Mohs C. [Intra-arterial thrombolysis of vessels supplying the brain]. Radiologe. Apr 1991;31(4):210-5. [Medline].
Bogousslavsky J, Regli F, Maeder P, et al. The etiology of posterior circulation infarcts: a prospective study using magnetic resonance imaging and magnetic resonance angiography. Neurology. Aug 1993;43(8):1528-33. [Medline].
Boysen G, Engell HC, Pistolese GR, et al. Editorial: On the critical lower level of cerebral blood flow in man with particular reference to carotid surgery. Circulation. Jun 1974;49(6):1023-5. [Medline].
Bruckmann H, Ferbert A, del Zoppo GJ, et al. Acute vertebral-basilar thrombosis. Angiologic-clinical comparison and therapeutic implications. Acta Radiol Suppl. 1986;369:38-42. [Medline].
Calvin SA, Beall DP, Ly JQ, et al. Basilar artery thrombosis. J Okla State Med Assoc. Aug 2004;97(8):334-6. [Medline].
Caplan LR. "Top of the basilar" syndrome. Neurology. Jan 1980;30(1):72-9. [Medline].
Caplan LR, Wityk RJ, Glass TA, et al. New England Medical Center Posterior Circulation registry. Ann Neurol. Sep 2004;56(3):389-98. [Medline].
Castaigne P, Lhermitte F, Gautier JC, et al. Arterial occlusions in the vertebro-basilar system. A study of 44 patients with post-mortem data. Brain. 1973;96(1):133-54. [Medline].
Chaves CJ, Caplan LR, Chung CS, et al. Cerebellar infarcts in the New England Medical Center Posterior Circulation Stroke Registry. Neurology. Aug 1994;44(8):1385-90. [Medline].
Coull BM, Goodnight SH. Antiphospholipid antibodies, prethrombotic states, and stroke. Stroke. Sep 1990;21(9):1370-4. [Medline].
Cravioto H, Rey-bellet, Prose PH, Feigin I. Occlusion of the basilar artery; a clinical and pathologic study of 14 autopsied cases. Neurology. Feb 1958;8(2):145-52. [Medline].
Cruz-Flores S, Gomez CR, Malkoff MD. Isolated vertigo as the presentation of severe basilar artery occlusive disease. Neurology. 1994;4(Suppl):A225.
Denny-Brown D. Basilar artery-syndromes. Bull New Engl Med Cent. Jun 1953;15(2):53-60. [Medline].
Denny-Brown D. The treatment of recurrent cerebrovascular symptoms and the question of "vasospasm". Med Clin North Am. Sep 1951;35(5):1457-74. [Medline].
Dirnagl U, Pulsinelli W. Autoregulation of cerebral blood flow in experimental focal brain ischemia. J Cereb Blood Flow Metab. May 1990;10(3):327-36. [Medline].
Ehsan T, Hayat G, Malkoff MD, et al. Hyperdense basilar artery. An early computed tomography sign of thrombosis. J Neuroimaging. Oct 1994;4(4):200-5. [Medline].
European Cooperative Study Group for Streptokinase Treatment in Acute Myocardial. Streptokinase in acute myocardial infarction. European Cooperative Study Group for Streptokinase Treatment in Acute Myocardial Infarction. N Engl J Med. Oct 11 1979;301(15):797-802. [Medline].
Feldmann E, Daneault N, Kwan E, et al. Chinese-white differences in the distribution of occlusive cerebrovascular disease. Neurology. Oct 1990;40(10):1541-5. [Medline].
Ferbert A, Bruckmann H, Drummen R. Clinical features of proven basilar artery occlusion. Stroke. Aug 1990;21(8):1135-42. [Medline].
Fieschi C, Agnoli A, Battistini N, et al. Derangement of regional cerebral blood flow and of its regulatory mechanisms in acute cerebrovascular lesions. Neurology. Dec 1968;18(12):1166-79. [Medline].
Fisher CM. Ocular Bobbing. Arch Neurol. Nov 1964;11:543-6. [Medline].
Fisher CM. Atherosclerosis of the carotid and vertebral arteries: extracranial and intracranial. J Neuropathol Exp Neurol. 1965;24:455-476.
Fisher CM. Some neuro-ophthalmological observations. J Neurol Neurosurg Psychiatry. Oct 1967;30(5):383-92. [Medline].
Ford GA. Intra-arterial thrombolysis is the treatment of choice for basilar thrombosis: con. Stroke. Sep 2006;37(9):2438-9. [Medline].
Gorelick PB, Caplan LR, Hier DB, et al. Racial differences in the distribution of posterior circulation occlusive disease. Stroke. Sep-Oct 1985;16(5):785-90. [Medline].
Gustafsson D, Elg M. The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review. Thromb Res. Jul 15 2003;109 Suppl 1:S9-15. [Medline].
Hacke W, Kaste M, Fieschi C, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. Oct 4 1995;274(13):1017-25. [Medline].
Hacke W, Zeumer H, Ferbert A, et al. Intra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease. Stroke. Oct 1988;19(10):1216-22. [Medline].
Haley EC, Kassell NF, Torner JC. Failure of heparin to prevent progression in progressing ischemic infarction. Stroke. Jan 1988;19(1):10-4. [Medline].
Hayem MG. Surla thrombose par arterite tronc basilaire. Comme cause du mort rapide. Arch Physiol Norm Pathol. 1868;1:270-289.
Heiss WD, Rosner G. Functional recovery of cortical neurons as related to degree and duration of ischemia. Ann Neurol. Sep 1983;14(3):294-301. [Medline].
Higashida RT, Tsai FY, Halbach VV, et al. Transluminal angioplasty for atherosclerotic disease of the vertebral and basilar arteries. J Neurosurg. Feb 1993;78(2):192-8. [Medline].
Horner J, Buoyer FG, Alberts MJ, Helms MJ. Dysphagia following brain-stem stroke. Clinical correlates and outcome. Arch Neurol. Nov 1991;48(11):1170-3. [Medline].
Huemer M, Niederwieser V, Ladurner G. Thrombolytic treatment for acute occlusion of the basilar artery. J Neurol Neurosurg Psychiatry. Feb 1995;58(2):227-8. [Medline].
Hurd K, Chopp M, Vande Linde AM, et al. Effects of moderate hyperglycemia on the temporal profile of brain tissue intracellular pH and [Mg2+] after global cerebral ischemia in rats. J Neurol Sci. Apr 1995;129(2):90-6. [Medline].
Johansson B, Strandgaard S, Lassen NA. On the pathogenesis of hypertensive encephalopathy. Circ Res. 1974;34-35 Suppl 1:I167-I171.
Kahrilas PJ. Pharyngeal structure and function. Dysphagia. 1993;8(4):303-7. [Medline].
Kay R, Wong KS, Yu YL, et al. Low-molecular-weight heparin for the treatment of acute ischemic stroke. N Engl J Med. Dec 14 1995;333(24):1588-93. [Medline].
Kinsella LJ, Feldmann E, Brooks JM. The clinical utility of transcranial Doppler ultrasound in suspected vertebrobasilar ischemia. J Neuroimaging. Apr 1993;3(2):115-22. [Medline].
Kitanaka C, Tanaka J, Kuwahara M, Teraoka A. Magnetic resonance imaging study of intracranial vertebrobasilar artery dissections. Stroke. Mar 1994;25(3):571-5. [Medline].
Knepper L, Biller J, Adams HP, et al. MR imaging of basilar artery occlusion. J Comput Assist Tomogr. Jan-Feb 1990;14(1):32-5. [Medline].
Kubik S, Adams RA. Occlusion of the basilar artery: A clinical and pathological study. Brain. 1946;69:6-121.
Labauge R, Pages M, Marty-Double C, et al. [Occlusion of the basilar artery. A review with 17 personal cases (author's transl)]. Rev Neurol (Paris). 1981;137(10):545-71. [Medline].
Lhermitte J, Trelles JO. [L arteriosclerose du tronc basilaire et ses consequences anatomo-cliniques]. Jahrbucher Psychiatrie Neurologie. 1934;51:91-107.
Lindsberg PJ, Soinne L, Roine RO, Tatlisumak T. Options for recanalization therapy in basilar artery occlusion. Stroke. Feb 2005;36(2):203-4. [Medline].
Lisboa RC, Jovanovic BD, Alberts MJ. Analysis of the safety and efficacy of intra-arterial thrombolytic therapy in ischemic stroke. Stroke. Dec 2002;33(12):2866-71. [Medline].
Mcdowell FH, Potes J, Groch S. The natural history of internal carotid and vertebral-basilar artery occlusion. Neurology. Apr 1961;11(4)Pt2:153-7. [Medline].
Mehler MF. The neuro-ophthalmologic spectrum of the rostral basilar artery syndrome. Arch Neurol. Sep 1988;45(9):966-71. [Medline].
Mehler MF. The rostral basilar artery syndrome: diagnosis, etiology, prognosis. Neurology. Jan 1989;39(1):9-16. [Medline].
Meyer JS. Circulatory changes following occlusion of the middle cerebral artery and their relation to function. J Neurosurg. Nov 1958;15(6):653-73. [Medline].
Millikan CH, Siekert RG. Studies in cerebrovascular disease. IV. The syndrome of intermittent insufficiency of the carotid arterial system. Mayo Clin Proc. May 4 1955;30(9):186-91. [Medline].
Moufarrij NA, Little JR, Furlan AJ, et al. Basilar and distal vertebral artery stenosis: long-term follow-up. Stroke. Sep-Oct 1986;17(5):938-42. [Medline].
Myers MG, Norris JW, Hachinski VC, et al. Cardiac sequelae of acute stroke. Stroke. Nov-Dec 1982;13(6):838-42. [Medline].
Nachman RL, Silverstein R. Hypercoagulable states. Ann Intern Med. Oct 15 1993;119(8):819-27. [Medline].
Nadeau S, Jordan J, Mishra S. Clinical presentation as a guide to early prognosis in vertebrobasilar stroke. Stroke. Feb 1992;23(2):165-70. [Medline].
Nedergaard M. Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction. Brain Res. Apr 7 1987;408(1-2):79-85. [Medline].
Nelson JR, Johnston CH. Ocular bobbing. Arch Neurol. Apr 1970;22(4):348-56. [Medline].
Nenci GG, Gresele P, Taramelli M, et al. Thrombolytic therapy for thromboembolism of vertebrobasilar artery. Angiology. Sep 1983;34(9):561-71. [Medline].
Norris JW, Hachinski VC, Myers MG, et al. Serum cardiac enzymes in stroke. Stroke. Sep-Oct 1979;10(5):548-53. [Medline].
Pessin MS, Gorelick PB, Kwan ES, Caplan LR. Basilar artery stenosis: middle and distal segments. Neurology. Nov 1987;37(11):1742-6. [Medline].
Pulsinelli WA, Waldman S, Rawlinson D, Plum F. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology. Nov 1982;32(11):1239-46. [Medline].
Qureshi AI, Boulos AS, Hanel RA, et al. Randomized comparison of intra-arterial and intravenous thrombolysis in a canine model of acute basilar artery thrombosis. Neuroradiology. Dec 2004;46(12):988-95. [Medline].
Rem JA, Hachinski VC, Boughner DR, Barnett HJ. Value of cardiac monitoring and echocardiography in TIA and stroke patients. Stroke. Nov-Dec 1985;16(6):950-6. [Medline].
Ringelstein EB, Zeumer H, Poeck K. Non-invasive diagnosis of intracranial lesions in the vertebrobasilar artery. Stroke. 1945;16:848-854.
Rother J, Wentz KU, Rautenberg W, et al. Magnetic resonance angiography in vertebrobasilar ischemia. Stroke. Sep 1993;24(9):1310-5. [Medline].
Sandercock PA, van den Belt AG, Lindley RI, Slattery J. Antithrombotic therapy in acute ischaemic stroke: an overview of the completed randomised trials. J Neurol Neurosurg Psychiatry. Jan 1993;56(1):17-25. [Medline].
Schellinger PD, Hacke W. Intra-arterial thrombolysis is the treatment of choice for basilar thrombosis: pro. Stroke. Sep 2006;37(9):2436-7. [Medline].
Schwartz A, Rautenberg W, Hennerici M. Dolichoectatic intracranial arteries: review of selected aspects. Cerebrovascular Disease. 1993;3:273-279.
Sharpe JA, Rosenberg MA, Hoyt WF, Daroff RB. Paralytic pontine exotropia. A sign of acute unilateral pontine gaze palsy and internuclear ophthalmoplegia. Neurology. Nov 1974;24(11):1076-81. [Medline].
Siekert RG, Millikan CH. Studies in cerebrovascular disease. II. Some clinical aspects of thrombosis of the basilar artery. Mayo Clin Proc. Mar 9 1955;30(5):93-100. [Medline].
Strandgaard S, MacKenzie ET, Sengupta D, et al. Upper limit of autoregulation of cerebral blood flow in the baboon. Circ Res. Apr 1974;34(4):435-40. [Medline].
Symon L, Pasztor E, Branston NM. The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: an experimental study by the technique of hydrogen clearance in baboons. Stroke. May-Jun 1974;5(3):355-64. [Medline].
Tettenborn B, Estol C, DeWitt LD. Accuracy of transcranial Doppler in the vertebrobasilar circulation. J Neurol. 1990;237:159.
The EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. N Engl J Med. Nov 7 1985;313(19):1191-200. [Medline].
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study G. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. Dec 14 1995;333(24):1581-7. [Medline].
The Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Study Group. Prognosis of patients with symptomatic vertebral or basilar artery stenosis. Stroke. Jul 1998;29(7):1389-92. [Medline].
Thompson JR, Simmons CR, Hasso AN, Hinshaw DB Jr. Occlusion of the intradural vertebrobasilar artery. Neuroradiology. Feb 17 1978;14(5):219-29. [Medline].
Verstraete M. The search for the ideal thrombolytic agent. J Am Coll Cardiol. Nov 1987;10(5 Suppl B):4B-10B. [Medline].
Vingerhoets F, Bogousslavsky J. Respiratory dysfunction in stroke. Clin Chest Med. Dec 1994;15(4):729-37. [Medline].
Voetsch B, DeWitt LD, Pessin MS, Caplan LR. Basilar artery occlusive disease in the New England Medical Center Posterior Circulation Registry. Arch Neurol. Apr 2004;61(4):496-504. [Medline].
Von Kummer R, Brandt T, Muller-Kuypers M. Thrombolytic therapy of basilar artery occlusion: preconditions for recanalization and good clinical outcome. In: Yamaguchi T, Mori E, Minematsu K, del Zoppo G, eds. Thrombolytic Therapy. 1995:343-348.
Vonofakos D, Marcu H, Hacker H. CT diagnosis of basilar artery occlusion. AJNR Am J Neuroradiol. May-Jun 1983;4(3):525-8. [Medline].
Wall M, Wray SH. The one-and-a-half syndrome--a unilateral disorder of the pontine tegmentum: a study of 20 cases and review of the literature. Neurology. Aug 1983;33(8):971-80. [Medline].
Waltz AG. Effect of blood pressure on blood flow in ischemic and in nonischemic cerebral cortex. The phenomena of autoregulation and luxury perfusion. Neurology. Jul 1968;18(7):613-21. [Medline].
Wardlaw JM, Warlow CP. Thrombolysis in acute ischemic stroke: does it work?. Stroke. Dec 1992;23(12):1826-39. [Medline].
Weinberger J. Noninvasive imaging of the cervical vertebral artery in the diagnosis of vertebrobasilar insufficiency. J Stroke Cerebrovasc Dis. 1991;1:21-25.
Whisnant JP, Cartlidge NE, Elveback LR. Carotid and vertebral-basilar transient ischemic attacks: effect of anticoagulants, hypertension, and cardiac disorders on survival and stroke occurrence--a population study. Ann Neurol. Feb 1978;3(2):107-15. [Medline].
Wildemann B, Hutschenreuter M, Krieger D, et al. Infusion of recombinant tissue plasminogen activator for treatment of basilar artery occlusion. Stroke. Oct 1990;21(10):1513-4. [Medline].
Zweifler RM. Management of acute stroke. South Med J. Apr 2003;96(4):380-5. [Medline].
Further Reading
Keywords
basilar artery occlusion, anterior inferior cerebellar artery, AICA, posterior cerebral artery, PCA, atherothrombosis, embolism, arterial dissection, atherosclerotic occlusion, vertebrobasilar insufficiency, VBI, stroke, hypertension, partial basilar artery occlusion, intravenous thrombolysis, atherosclerotic basilar artery stenosis, occlusion of the distal basilar artery, pontine ischemia, locked-in syndrome, top-of-the-basilar syndrome, stroke, neck injury, chiropractic manipulation, atrial fibrillation.
Follow-up: Basilar Artery Thrombosis