Mechanical Thrombolysis in Acute Stroke: Multimedia

References

1. NINDS t-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. Dec 14 1995;333(24):1581-7. [Medline].

2. NINDS t-PA Stroke Study Group. Generalized efficacy of t-PA for acute stroke. Subgroup analysis of the NINDS t-PA Stroke Trial. Stroke. Nov 1997;28(11):2119-25. [Medline].

3. Berlis A, Lutsep H, Barnwell S, et al. Mechanical thrombolysis in acute ischemic stroke with endovascular photoacoustic recanalization. Stroke. May 2004;35(5):1112-6. [Medline].

4. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. Dec 1 1999;282(21):2003-11. [Medline].

5. Whisenant BK, Baim DS, Kuntz RE, et al. Rheolytic thrombectomy with the Possis AngioJet: technical considerations and initial clinical experience. J Invasive Cardiol. Jul 1999;11(7):421-6. [Medline].

6. Wikholm G. Mechanical intracranial embolectomy: A report of two cases. Interventional Neuroradiol. 1998;4:159-64.

7. Clark WM, Buckley LA, Nesbit GM. Intraarterial laser thrombolysis therapy for clinical stroke: A feasibility study. Stroke. 2000;31:307.

8. Lutsep HL, Campbell M, Clark WM. EPAR therapy system for treatment of acute stroke: Safety study results. Stroke. 2001;32:319b.

9. Atar S, Luo H, Nagai T, et al. Arterial thrombus dissolution in vivo using a transducer-tipped, high- frequency ultrasound catheter and local low-dose urokinase delivery. J Endovasc Ther. Jun 2001;8(3):282-90. [Medline].

10. Mahon BR, Nesbit GM, Barnwell SL. The North American clinical experience with the EKOS ultrasound thrombolytic drug infusion catheter for treatment of embolic stroke. Presented at: Annual Meeting of the American Society of Neuroradiology. April 26, 2001; Boston, MA.

11. The IMS II Trial Investigators. The Interventional Management of Stroke (IMS) II Study. Stroke. Jul 2007;38(7):2127-35. [Medline].

12. Gobin YP, Starkman S, Duckwiler GR, Grobelny T, Kidwell CS, Jahan R. MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia. Stroke. Dec 2004;35(12):2848-54. [Medline].

13. Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. Jul 2005;36(7):1432-8. [Medline].

14. Smith WS. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke. Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. AJNR Am J Neuroradiol. Jun-Jul 2006;27(6):1177-82. [Medline].

15. Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke. Apr 2008;39(4):1205-12. [Medline].

16. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. Oct 4 1995;274(13):1017-25. [Medline].

17. Bose A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A. The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol. Aug 2008;29(7):1409-13. [Medline].

18. Lutsep HL, Clark WM, Nesbit GM, et al. Intraarterial suction thrombectomy in acute stroke. AJNR Am J Neuroradiol. May 2002;23(5):783-6. [Medline].

Further Reading

Keywords

stroke, stroke treatment, mechanical embolectomy, mechanical thrombectomy, endovascular thrombectomy, intraarterial treatment of acute stroke, intra-arterial treatment of acute stroke, IA treatment of acute stroke, intraarterial thrombolysis, intra-arterial thrombolysis, IA thrombolysis, tissue-type plasminogen activator, tissue plasminogen activator, tPA, t-PA, mechanical thrombolysis in acute stroke

Contributor Information and Disclosures

Author

Helmi L Lutsep, MD, Professor, Department of Neurology, Oregon Health & Science University; Associate Director, Oregon Stroke Center
Helmi L Lutsep, MD is a member of the following medical societies: American Academy of Neurology and American Stroke Association
Disclosure: Co-Axia Consulting fee Review panel membership; Talecris Consulting fee Review panel membership; AGA Medical Consulting fee Review panel membership; Boehringer Ingelheim Honoraria Speaking and teaching; Concentric Medical Consulting fee Review panel membership; Abbott Consulting fee Consulting; Sanofi  Consulting

Medical Editor

Richard M Zweifler, MD, Chief of Neurology, Sentara Healthcare, Norfolk, VA; Professor of Neurology, Eastern Virginia Medical School, Norfolk, VA
Richard M Zweifler, MD is a member of the following medical societies: American Academy of Neurology, American Heart Association, American Medical Association, American Stroke Association, Royal Society of Medicine, and Stroke Council of the American Heart Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Howard S Kirshner, MD, Professor of Neurology, Psychiatry and Hearing and Speech Sciences, Vice Chairman, Department of Neurology, Vanderbilt University School of Medicine; Director, Vanderbilt Stroke Center; Program Director, Stroke Service, Vanderbilt Stallworth Rehabilitation Hospital; Consulting Staff, Department of Neurology, Nashville Veterans Affairs Medical Center
Howard S Kirshner, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, American Heart Association, American Medical Association, American Neurological Association, American Society of Neurorehabilitation, National Stroke Association, Phi Beta Kappa, and Tennessee Medical Association
Disclosure: Boehringer Ingelheim Honoraria Speaking and teaching; BMS/Sanofi Honoraria Speaking and teaching; Novartis Honoraria Speaking and teaching

CME Editor

Selim R Benbadis, MD, Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, University of South Florida School of Medicine, Tampa General Hospital
Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Stephen A Berman, MD, PhD, Professor, Department of Internal Medicine, Section of Neurology, Dartmouth Medical School; Chief, Neurology Service, White River Junction Veterans Medical Center
Stephen A Berman, MD, PhD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, and Phi Beta Kappa
Disclosure: Nothing to disclose.