Central Nervous System Lymphoma in HIV Differential Diagnoses
- Author: Florian P Thomas, MD, PhD, Drmed, MA, MS; Chief Editor: Niranjan N Singh, MD, DM more...
CNS toxoplasmosis is the most important differential. A solitary mass is usually primary CNS lymphoma; toxoplasmosis usually manifests as multiple lesions, but single lesions occur in a significant minority of toxoplasmosis cases. CNS lymphoma is the most common space-occupying lesion associated with AIDS. CNS lymphoma is less common than toxoplasmosis, but because of the difficulty in differentiating the 2 conditions clinically and radiologically, both need to be considered in the differential diagnosis of CNS space-occupying lesions in AIDS.
Diagnostic considerations also include the following:
- Brainstem syndromes
- Cluster headache
- Glioblastoma multiforme
Confusional States and Acute Memory Disorders
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