eMedicine Specialties > Neurology > Neuromuscular Diseases

Amyotrophic Lateral Sclerosis: Multimedia

Author: Carmel Armon, MD, MSc, MHS, Professor of Neurology, Tufts University School of Medicine; Chief, Division of Neurology, Baystate Medical Center
Contributor Information and Disclosures

Updated: Jun 29, 2009

Multimedia

The 4 regions or levels of the body. Bulbar (musc...
(Enlarge Image)
Media file 1: The 4 regions or levels of the body. Bulbar (muscles of the face, mouth, and throat); cervical (muscles of the back of the head and the neck, the shoulders and upper back, and the upper extremities); thoracic (muscles of the chest and abdomen and the middle portion of the spinal muscles); lumbosacral (muscles of the lower back, groin, and lower extremities)
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The 4 regions or levels of the body. Bulbar (musc...

The 4 regions or levels of the body. Bulbar (muscles of the face, mouth, and throat); cervical (muscles of the back of the head and the neck, the shoulders and upper back, and the upper extremities); thoracic (muscles of the chest and abdomen and the middle portion of the spinal muscles); lumbosacral (muscles of the lower back, groin, and lower extremities)

Malignant biochemical transformation hypothesis. ...
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Media file 2: Malignant biochemical transformation hypothesis. Risk factors operate up-stream to a putative malignant biochemical transformation, which causes the appearance of endogenous ALS-specific toxins. These putative toxins spread, behaving like a metastasizing biochemical malignancy, and cause the downstream biochemical, histologic and clinical consequences of ALS. (Adapted from Armon C. ALS: Clinical and Epidemiologic Clues to Pathogenesis. In: Neurobiology of ALS. Course Syllabus, 51st Annual Meeting. American Academy of Neurology, 1999.)
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Malignant biochemical transformation hypothesis. ...

Malignant biochemical transformation hypothesis. Risk factors operate up-stream to a putative malignant biochemical transformation, which causes the appearance of endogenous ALS-specific toxins. These putative toxins spread, behaving like a metastasizing biochemical malignancy, and cause the downstream biochemical, histologic and clinical consequences of ALS. (Adapted from Armon C. ALS: Clinical and Epidemiologic Clues to Pathogenesis. In: Neurobiology of ALS. Course Syllabus, 51st Annual Meeting. American Academy of Neurology, 1999.)

Muscle in nerve disease. Image courtesy of Dr. Fr...
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Media file 3: Muscle in nerve disease. Image courtesy of Dr. Friedlander, Associate Professor and Chair of Pathology at Kansas City University of Medicine and Biosciences.
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Muscle in nerve disease. Image courtesy of Dr. Fr...

Muscle in nerve disease. Image courtesy of Dr. Friedlander, Associate Professor and Chair of Pathology at Kansas City University of Medicine and Biosciences.

More on Amyotrophic Lateral Sclerosis

Overview: Amyotrophic Lateral Sclerosis
Differential Diagnoses & Workup: Amyotrophic Lateral Sclerosis
Treatment & Medication: Amyotrophic Lateral Sclerosis
Follow-up: Amyotrophic Lateral Sclerosis
Multimedia: Amyotrophic Lateral Sclerosis
References
Further Reading
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Further Reading

  • ALS Association, Living With ALS Manuals
  • Muscular Dystrophy Association: MDA ALS Caregiver’s Guide  
  • Brown Jr, RH, Swash M, Pasinelli P, eds. Amyotrophic Lateral Sclerosis. 2nd Edition. Informa Healthcare,
2006.
  • Mitsumoto H, Przedborski S, Gordon PH, eds. Amyotrophic Lateral Sclerosis. Taylor and Francis. 2006.
  • Miller RG, Gelinas D, O'Connor P. Amyotrophic Lateral Sclerosis. AAN Press. Demos 2004.

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Keywords

amyotrophic lateral sclerosis, ALS, Lou Gehrig disease, Lou Gehrig's disease, Charcot disease, Charcot's disease, motor neuron disease

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Contributor Information and Disclosures

Author

Carmel Armon, MD, MSc, MHS, Professor of Neurology, Tufts University School of Medicine; Chief, Division of Neurology, Baystate Medical Center
Carmel Armon, MD, MSc, MHS is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Association of Neuromuscular and Electrodiagnostic Medicine, American Clinical Neurophysiology Society, American College of Physicians, American Epilepsy Society, American Medical Association, American Neurological Association, American Stroke Association, Massachusetts Medical Society, Movement Disorders Society, and Sigma Xi
Disclosure: Nothing to disclose.

Medical Editor

Donald B Sanders, MD, EMG Laboratory Director, Professor of Medicine (Neurology), Division of Neurology, Duke University Medical Center
Donald B Sanders, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Neurological Association, and New York Academy of Sciences
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Neil A Busis, MD, Chief, Division of Neurology, Department of Medicine, Head, Clinical Neurophysiology Laboratory, University of Pittsburgh Medical Center-Shadyside
Neil A Busis, MD is a member of the following medical societies: American Academy of Neurology and American Association of Neuromuscular and Electrodiagnostic Medicine
Disclosure: Nothing to disclose.

CME Editor

Selim R Benbadis, MD, Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, University of South Florida School of Medicine, Tampa General Hospital
Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Nicholas Y Lorenzo, MD, Chief Editor, eMedicine Neurology; Consulting Staff, Neurology Specialists and Consultants
Nicholas Y Lorenzo, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Neurology
Disclosure: Nothing to disclose.

 
 
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