eMedicine Specialties > Neurology > Neuromuscular Diseases

Thyroid Disease: Follow-up

Author: Gabriel Bucurescu, MD, MS, Staff Neurologist, Neurology Service, Philadelphia Veterans Affairs Medical Center
Contributor Information and Disclosures

Updated: Jan 29, 2009

Follow-up

Further Inpatient Care

  • Neurologic manifestations in thyroid diseases are manageable on an outpatient basis. Therapy is maintained for months (if not years). In most cases, neurologic abnormalities slowly resolve.
  • Thyroid storm and myxedema coma are exceptions. Both are emergencies that require aggressive treatment in the ICU. The mortality rate of thyroid storm can be as high as 20-40%. The symptoms usually are exaggerated manifestations of the symptoms seen in hyperthyroidism; a superimposed infection and the stress associated with it would exacerbate the symptoms. Fever, abdominal pain, delirium, and psychosis can occur. The patient may become obtunded. Thyroid storm should be suspected in any patient with severe hyperpyrexia, tachycardia, and a goiter.

Further Outpatient Care

Pregnant patients require follow-up at least monthly. Closely observe these newborns for thyroid disease.

Prognosis

Prognosis is generally good, since most symptoms are reversible with correction of the underlying problem.

Patient Education

For excellent patient education resources, visit eMedicine's Endocrine System Center. Also, see eMedicine's patient education article Thyroid Problems.

Miscellaneous

Medicolegal Pitfalls

Generally, no specific problem is anticipated unless the diagnosis is missed for months or years, which then results in permanent sequelae. However, such delays can occur because the early symptoms can be nonspecific.

 


More on Thyroid Disease

Overview: Thyroid Disease
Differential Diagnoses & Workup: Thyroid Disease
Treatment & Medication: Thyroid Disease
Follow-up: Thyroid Disease
References

References

  1. Guimaraes J, Santos L, Bugalho P. Painful legs and moving toes syndrome associated with Hashimoto's disease. Eur J Neurol. Mar 2007;14(3):343-5. [Medline].

  2. Chia SY, Chua R, Lo YL, Wong MC, Chan LL, Tan EK. Acute ataxia, Graves' disease, and stiff person syndrome. Mov Disord. Oct 15 2007;22(13):1969-71. [Medline].

  3. Blanchin S, Coffin C, Viader F, Ruf J, Carayon P, Potier F, et al. Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes. J Neuroimmunol. Dec 2007;192(1-2):13-20. [Medline].

  4. Sinclair C, Gilchrist JM, Hennessey JV, Kandula M. Muscle carnitine in hypo- and hyperthyroidism. Muscle Nerve. Sep 2005;32(3):357-9. [Medline].

  5. Alevizaki M, Synetou M, Xynos K, Alevizaki CC, Vemmos KN. Hypothyroidism as a protective factor in acute stroke patients. Clin Endocrinol (Oxf). Sep 2006;65(3):369-72. [Medline].

  6. Dai A, Wasay M, Dubey N, Giglio P, Bakshi R. Superior sagittal sinus thrombosis secondary to hyperthyroidism. J Stroke Cerebrovasc Dis. Mar-Apr 2000;9(2):89-90. [Medline].

  7. Ni J, Gao S, Cui LY, Li SW. Intracranial arterial occlusive lesion in patients with Graves' disease. Chin Med Sci J. Sep 2006;21(3):140-4. [Medline].

  8. Peralta AR, Canhão P. Hypothyroidism and cerebral vein thrombosis--a possible association. J Neurol. Jul 2008;255(7):962-6. [Medline].

  9. Adams RD, Victor M, Ropper AH. The endocrine myopathies. In: 6th ed. Principles of Neurology. 1997. New York: McGraw-Hill; 1440-2.

  10. Ahdab R, Thomas D. Palatal tremor, focal seizures, repeated miscarriages and elevated anti-thyroid antibodies. Clin Neurol Neurosurg. Apr 2008;110(4):381-3. [Medline].

  11. Avramides A, Papamargaritis K, Mavromatis I, et al. Visual evoked potentials in hypothyroid and hyperthyroid patients before and after achievement of euthyroidism. J Endocrinol Invest. 1992;15:749-753. [Medline].

  12. Boyages SC, Halpern J-P. Endemic cretinism: toward a unifying hypothesis. Thyroid. 1993;3(1):59-69. [Medline].

  13. Calza L, Aloe L, Giardino L. Thyroid hormone-induced plasticity in the adult rat brain. Brain Res Bull. 1997;44(4):549-57. [Medline].

  14. Comi AM, Bellamkonda S, Ferenc LM, Cohen BA, Germain-Lee EL. Central hypothyroidism and Sturge-Weber syndrome. Pediatr Neurol. Jul 2008;39(1):58-62. [Medline].

  15. DeLong GR. The neuromuscular system and brain in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. 7th ed. Philadelphia: Lippincott-Raven; 1996:826-35.

  16. DeLong GR. The neuromuscular system and brain in thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. 7th ed. Philadelphia: Lippincott-Raven; 1996:645-52.

  17. Donati L, Antonelli A, Bertoni F, et al. Clinical picture of endemic cretinism in central Apennines (Montefeltro). Thyroid. 1992;2(4):283-290. [Medline].

  18. Duhig TJ, McKeag D. Thyroid disorders in athletes. Curr Sports Med Rep. Jan-Feb 2009;8(1):16-9. [Medline].

  19. Ferracci F, Carnevale A. The neurological disorder associated with thyroid autoimmunity. J Neurol. Aug 2006;253(8):975-84. [Medline].

  20. Halpern J-P, Boyages SC, Maberly GF, et al. The neurology of endemic cretinism. Brain. 1991;114:825-841. [Medline].

  21. Hsieh MJ, Lyu RK, Chang WN, Chang KH, Chen CM, Chang HS, et al. Hypokalemic thyrotoxic periodic paralysis: clinical characteristics and predictors of recurrent paralytic attacks. Eur J Neurol. Jun 2008;15(6):559-64. [Medline].

  22. Jagannathan NR, Tandon N, Raghunathan P, Kochupillai N. Reversal of abnormalities of myelination by thyroxine therapy in congenital hypothyroidism: localized in vivo proton magnetic resonance spectroscopy (MRS) study. Brain Res Dev Brain Res. Aug 8 1998;109(2):179-86. [Medline].

  23. Kurne A, Aydin OF, Karabudak R. White matter alteration in a patient with Graves' disease. J Child Neurol. Sep 2007;22(9):1128-31. [Medline].

  24. Lai CL, Liu CK, Tai CT, et al. A study of central and peripheral nerve conduction in patients with primary hypothyroidism: the effects of thyroxine replacement. Kaohsiung J Med Sci. May 1998;14(5):294-302. [Medline].

  25. Larsen PR. The thyroid. In: Wyngaarden JB, Smith LH Jr, Bennett JC, et al, eds. Cecil Textbook of Medicine. 19th ed. Philadelphia: Saunders; 1992:1248-71.

  26. Losa M, Mortini P, Minelli R, Giovanelli M. Coexistence of TSH-secreting pituitary adenoma and autoimmune hypothyroidism. J Endocrinol Invest. 2006;29:555-559. [Medline].

  27. Madeira MD, Cadete-Leite A, Andrade JP, et al. Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: a morphometric study. J Comp Neurol. Dec 1 1991;314(1):171-86. [Medline].

  28. Marta CB, Adamo AM, Soto EF, Pasquini JM. Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system. J Neurosci Res. Jul 15 1998;53(2):251-9. [Medline].

  29. Mavragani CP, Patronas N, Dalakas M, Moutsopoulos HM. Ill-defined neurological syndromes with autoimmune background: a diagnostic challenge. J Rheumatol. Feb 2007;34(2):341-5. [Medline].

  30. Muthipeedika JM, Moosa A, Kumar A, Suchowersky O. Bilateral chorea--ballism associated with hyperthyroidism. Mov Disord. Apr 2005;20(4):512; author reply 512. [Medline].

  31. Ozata M, Ozkardes A, Corakci A, Gundogan MA. Subclinical hypothyroidism does not lead to alterations either in peripheral nerves or in brainstem auditory evoked potentials (BAEPs). Thyroid. 1995;5(3):201-205. [Medline].

  32. Ozata M, Ozkardes A, Dolu H, et al. Evaluation of central motor conduction in hypothyroid and hyperthyroid patients. J Endocrinol Invest. 1996;19:670-677. [Medline].

  33. Ozkan Y, Colak R. Sheehan syndrome: clinical and laboratory evaluation of 20 cases. Neuro Endocrinol Lett. Jun 2005;26(3):257-60. [Medline].

  34. Ozkardes A, Ozata M, Beyhan Z, et al. Acute hypothyroidism leads to reversible alterations in central nervous system as revealed by somatosensory evoked potentials. Electroencephalography and clinical neurophysiology. 1996;100:500-504. [Medline].

  35. Parker RJ, Davidson AC. Hypothyroidism--an unexpected diagnosis following emergency treatment for heatstroke. Int J Clin Pract Suppl. Apr 2005;31-3. [Medline].

  36. Perelman AH, Clemons RD. The fetus in maternal hyperthyroidism. Thyroid. 1992;2(3):225-228. [Medline].

  37. Powner DJ, Boccalandro C, Alp MS, Vollmer DG. Endocrine failure after traumatic brain injury in adults. Neurocrit Care. 2006;5(1):61-70. [Medline].

  38. Quattrini A, Nemni R, Marchettini P, et al. Effect of hypothyroidism on rat peripheral nervous system. Neuroreport. 1993;4:499-502. [Medline].

  39. Sahni V, Gupta N, Anuradha S, Tatke M, Kar P. Thyrotoxic neuropathy- an under diagnosed condition. Med J Malaysia. Mar 2007;62(1):76-7. [Medline].

  40. Somay G, Oflazoglu B, Us O, Surardamar A. Neuromuscular status of thyroid diseases: a prospective clinical and electrodiagnostic study. Electromyogr Clin Neurophysiol. Mar-Apr 2007;47(2):67-78. [Medline].

  41. Tamburini G, Tacconi P, Ferrigno P, et al. Visual evoked potentials in hypothyroidism: a long-term evaluation. Electromyogr Clin Neurophysiol. 1998;38:201-205. [Medline].

  42. Tuncel D, Cetinkaya A, Kaya B, Gokce M. Hoffmann's syndrome: a case report. Med Princ Pract. 2008;17(4):346-8. [Medline].

Further Reading

Keywords

thyroid neuropathy, thyroid myopathy, hyperthyroidism, hypothyroidism, Graves disease, myxedema, cretinism, thyrotoxicosis, Graves ophthalmopathy, thyroid eye disease, thyroid ophthalmopathy, thyroid orbitopathy, infiltrative ophthalmopathy, thyroid disease, T3, T4, thyroxine, thyroid hormones, regulation of thyroid hormones, myasthenia gravis, chronic thyrotoxic myopathy

Contributor Information and Disclosures

Author

Gabriel Bucurescu, MD, MS, Staff Neurologist, Neurology Service, Philadelphia Veterans Affairs Medical Center
Gabriel Bucurescu, MD, MS is a member of the following medical societies: American Academy of Neurology, American Clinical Neurophysiology Society, and American Epilepsy Society
Disclosure: Nothing to disclose.

Medical Editor

Thomas A Kent, MD, Professor, Department of Neurology, Baylor College of Medicine; Neurology Care Line Executive, Michael E DeBakey Veterans Affairs Medical Center
Thomas A Kent, MD is a member of the following medical societies: American Academy of Neurology, American Neurological Association, New York Academy of Sciences, Royal Society of Medicine, Sigma Xi, and Stroke Council of the American Heart Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Agapito S Lorenzo, MD, Laboratory Director, Associate Professor, Departments of Neurology, Creighton University and University of Nebraska Medical Center
Agapito S Lorenzo, MD is a member of the following medical societies: American Academy of Neurology and American Association of Neuromuscular and Electrodiagnostic Medicine
Disclosure: Nothing to disclose.

CME Editor

Matthew J Baker, MD, Consulting Staff, Collier Neurologic Specialists, Naples Community Hospital
Matthew J Baker, MD is a member of the following medical societies: American Academy of Neurology
Disclosure: Nothing to disclose.

Chief Editor

Nicholas Y Lorenzo, MD, Chief Editor, eMedicine Neurology; Consulting Staff, Neurology Specialists and Consultants
Nicholas Y Lorenzo, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Neurology
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.