eMedicine Specialties > Neurology > Pediatric Neurology
Craniosynostosis: Differential Diagnoses & Workup
Updated: Nov 12, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Differential Diagnoses
| Benign Skull Tumors | Thyroid Disease |
| Hydrocephalus | Torticollis |
| Mental Retardation | |
| Neural Tube Defects | |
| Syringomyelia |
Other Problems to Be Considered
Apert syndrome
Carpenter syndrome
Chotzen syndrome
Crouzon syndrome
Hypercalcemia
Hyperthyroidism
Hypophosphatemia
Kleeblattschãdel (cloverleaf skull)
Pfeiffer syndrome
Positional molding
Renal osteodystrophy
Rickets
Vitamin D deficiency
Workup
Imaging Studies
- When careful examination of the cranial shape cannot establish the diagnosis, skull radiographs can be obtained.
- Perform skull radiography with anterior-posterior, lateral, and Water views. Prematurely fused sutures are easily identified by the absence of sutures and associated ridging of the suture line. Sutures either are not visible or have evidence of sclerosis.
- Cranial CT scan with 3-dimensional reconstruction is not required in most infants. It is sometimes performed when surgery is being considered.
- Nuclear medicine isotope studies are of limited value.
Other Tests
Endocrine evaluation: Order thyroid and parathyroid studies when associated features suggest these diagnoses.
More on Craniosynostosis |
| Overview: Craniosynostosis |
Differential Diagnoses & Workup: Craniosynostosis |
| Treatment & Medication: Craniosynostosis |
| Follow-up: Craniosynostosis |
| Multimedia: Craniosynostosis |
| References |
| Further Reading |
| « Previous Page | Next Page » |
References
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Higginbottom MC, Jones KL, James HE. Intrauterine constraint and craniosynostosis. Neurosurgery. Jan 1980;6(1):39-44. [Medline].
Sheth RD, Schaefer GB, Keller GM, et al. Size of the corpus callosum in cerebral palsy. J Neuroimaging. Jul 1996;6(3):180-3. [Medline].
Schaefer GB, Sheth RD, Bodensteiner JB. Cerebral dysgenesis. An overview. Neurol Clin. Nov 1994;12(4):773-88. [Medline].
Losee JE, Corde Mason A. Deformational plagiocephaly: diagnosis, prevention, and treatment. Clin Plast Surg. Jan 2005;32(1):53-64. [Medline].
Robin NH. Molecular genetic advances in understanding craniosynostosis. Plast Reconstr Surg. Mar 1999;103(3):1060-70. [Medline].
Anderson PJ, Netherway DJ, Abbott A, David DJ. Intracranial Volume Measurement of Metopic Craniosynostosis. J Craniofac Surg. 11 2004;15(6):1014-1016. [Medline].
Cunningham ML, Heike CL. Evaluation of the infant with an abnormal skull shape. Curr Opin Pediatr. Dec 2007;19(6):645-51. [Medline].
Dundulis JA, Becker DB, Govier DP, et al. Coronal ring involvement in patients treated for unilateral coronal craniosynostosis. Plast Reconstr Surg. Dec 2004;114(7):1695-703. [Medline].
Elmslie FV, Reardon W. Craniofacial developmental abnormalities. Curr Opin Neurol. Apr 1998;11(2):103-8. [Medline].
Fernbach SK. Craniosynostosis 1998: concepts and controversies. Pediatr Radiol. Sep 1998;28(9):722-8. [Medline].
Liptak GS, Serletti JM. Pediatric approach to craniosynostosis. Pediatr Rev. Oct 1998;19(10):352; quiz 359. [Medline].
Sheth RD, Mullett MD, Bodensteiner JB, Hobbs GR. Longitudinal head growth in developmentally normal preterm infants. Arch Pediatr Adolesc Med. Dec 1995;149(12):1358-61. [Medline].
Keywords
craniosynostosis, abnormal head shape, ossification, primary craniosynostosis, failure of brain growth, secondary craniosynostosis, simple craniosynostosis, complex craniosynostosis, compound craniosynostosis, syndromic craniosynostosis, anterior plagiocephaly, Apert syndrome, brachycephaly, Carpenter syndrome, Chotzen syndrome, Crouzon syndrome, kleeblattschãdel, cloverleaf skull, oxycephaly, Pfeiffer syndrome, plagiocephaly, scaphocephaly, trigonocephaly
Differential Diagnoses & Workup: Craniosynostosis