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Myoclonic Epilepsy Beginning in Infancy or Early Childhood: Follow-up

Author: Raj D Sheth, MD, Professor of Neurology, Mayo College of Medicine; Chief, Division of Pediatric Neurology, Nemours Children's Clinic
Contributor Information and Disclosures

Updated: Aug 21, 2008

Follow-up

Further Outpatient Care

  • Serial EEGs often are required to ensure that patients are responding to treatment and that subclinical seizures are not occurring.
  • Typical EEG findings in responsive patients include the disappearance of polyspike and wave activity and other associated epileptiform discharges.

Prognosis

  • Prognosis depends on the underlying etiology and the syndrome type.
  • Patients with a benign syndrome typically respond well to medication. These patients usually have a good prognosis and often outgrow the epilepsy.
  • In symptomatic myoclonic epilepsy syndromes, the prognosis is usually less favorable with regard to seizure control and developmental progress.
 


More on Myoclonic Epilepsy Beginning in Infancy or Early Childhood

Overview: Myoclonic Epilepsy Beginning in Infancy or Early Childhood
Differential Diagnoses & Workup: Myoclonic Epilepsy Beginning in Infancy or Early Childhood
Treatment & Medication: Myoclonic Epilepsy Beginning in Infancy or Early Childhood
Follow-up: Myoclonic Epilepsy Beginning in Infancy or Early Childhood
References

References

  1. Zara F, Gennaro E, Stabile M, Carbone I, Malacarne M, Majello L, et al. Mapping of a locus for a familial autosomal recessive idiopathic myoclonic epilepsy of infancy to chromosome 16p13. Am J Hum Genet. May 2000;66(5):1552-7. [Medline].

  2. Wang PJ, Lee WT, Hwu WL, Young C, Yau KI, Shen YZ. The controversy regarding diagnostic criteria for early myoclonic encephalopathy. Brain Dev. Oct 1998;20(7):530-5. [Medline].

  3. Aicardi J. Myoclonic epilepsies of infancy and childhood. Adv Neurol. 1986;43:11-31. [Medline].

  4. Sheth RD. Electroencephalogram in developmental delay: specific electroclinical syndromes. Semin Pediatr Neurol. Mar 1998;5(1):45-51. [Medline].

  5. Doose H, Lunau H, Castiglione E, Waltz S. Severe idiopathic generalized epilepsy of infancy with generalized tonic-clonic seizures. Neuropediatrics. Oct 1998;29(5):229-38. [Medline].

  6. Wallace SJ. Myoclonus and epilepsy in childhood: a review of treatment with valproate, ethosuximide, lamotrigine and zonisamide. Epilepsy Res. Jan 1998;29(2):147-54. [Medline].

  7. Lombroso CT. Early myoclonic encephalopathy, early infantile epileptic encephalopathy, and benign and severe infantile myoclonic epilepsies: a critical review and personal contributions. J Clin Neurophysiol. Jul 1990;7(3):380-408. [Medline].

  8. Shahwan A, Farrell M, Delanty N. Progressive myoclonic epilepsies: a review of genetic and therapeutic aspects. Lancet Neurol. Apr 2005;4(4):239-48. [Medline].

Further Reading

Keywords

myoclonic epilepsy, myoclonic seizures, astatic myoclonic epilepsy of Doose, benign infantile myoclonic epilepsy, infantile spasms, progressive myoclonic epilepsy, severe infantile myoclonic epilepsy

Contributor Information and Disclosures

Author

Raj D Sheth, MD, Professor of Neurology, Mayo College of Medicine; Chief, Division of Pediatric Neurology, Nemours Children's Clinic
Raj D Sheth, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics, American Epilepsy Society, American Neurological Association, and Child Neurology Society
Disclosure: Nothing to disclose.

Medical Editor

James J Riviello Jr, MD, George Peterkin Endowed Chair in Pediatrics, Professor of Pediatrics, Section of Neurology and Developmental Neuroscience, Professor of Neurology, Peter Kellaway Section of Neurophysiology, Baylor College of Medicine; Chief of Neurophysiology, Director of the Epilepsy and Neurophysiology Program, Texas Children's Hospital
James J Riviello Jr, MD is a member of the following medical societies: American Academy of Pediatrics
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Kenneth J Mack, MD, PhD, Senior Associate Consultant, Department of Child and Adolescent Neurology, Mayo Clinic
Kenneth J Mack, MD, PhD is a member of the following medical societies: American Academy of Neurology, Child Neurology Society, Phi Beta Kappa, and Society for Neuroscience
Disclosure: Nothing to disclose.

Chief Editor

Amy Kao, MD, Assistant Professor, Department of Pediatrics, Division of Pediatric Neurology, Department of Neurology, Oregon Health and Science University; Consulting Staff, Shriners Hospital for Children
Amy Kao, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics, American Epilepsy Society, and Child Neurology Society
Disclosure: Nothing to disclose.

 
 
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