eMedicine Specialties > Neurology > Pediatric Neurology
Neurofibromatosis, Type 2: Multimedia
Updated: Dec 10, 2008
Multimedia
![]() | Media file 1: Subcutaneous and cutaneous lesions in a young man with neurofibromatosis type 2; note paucity of cafe-au-lait spots. |
![]() | Media file 2: Right neck mass in a patient with neurofibromatosis type 2. |
![]() | Media file 3: Facial asymmetry, OS proptosis, and exotropia as well as several subcutaneous lesions on the forehead and face in a 20-year-old man with neurofibromatosis type 2. |
![]() | Media file 4: Posterior cervical scar from cord lesion resection, thoracic scoliosis, and subcutaneous masses in a young adult with neurofibromatosis type 2. |
![]() | Media file 5: Meningioma to the left of midline in a patient with neurofibromatosis type 2. |
![]() | Media file 6: Multiple meningiomas (on the left) on the surface of brain in a patient with neurofibromatosis type 2. |
![]() | Media file 7: Bilateral acoustic neuromas in a patient with neurofibromatosis type 2. |
![]() | Media file 8: Bilateral acoustic neuromas and a left-sided meningioma in a patient with neurofibromatosis type 2. |
![]() | Media file 9: Small ependymoma in a patient with neurofibromatosis type 2. |
![]() | Media file 10: Multiple meningiomas in a patient with neurofibromatosis type 2. |
More on Neurofibromatosis, Type 2 |
| Overview: Neurofibromatosis, Type 2 |
| Differential Diagnoses & Workup: Neurofibromatosis, Type 2 |
| Treatment & Medication: Neurofibromatosis, Type 2 |
| Follow-up: Neurofibromatosis, Type 2 |
Multimedia: Neurofibromatosis, Type 2 |
| References |
| « Previous Page |
References
Fisher LM, Doherty JK, Lev MH, ET et al. Distribution of nonvestibular cranial nerve schwannomas in neurofibromatosis 2. Otol Neurotol. Dec 2007;28(8):1083-90. [Medline].
Hanemann CO. Magic but treatable? Tumours due to loss of merlin. Brain. Mar 2008;131:606-15. [Medline].
Sestini R, Provenzano A, Bacci C, et al. NF2 mutation screening by denaturing high-performance liquid chromatography and high-resolution melting analysis. Genet Test. Jun 2008;12(2):311-8. [Medline].
Plotkin SR, Singh MA, O'Donnell CC, et al. Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy. Nat Clin Pract Oncol. Aug 2008;5(8):487-91. [Medline].
Schwartz MS, Otto SR, Shannon RV, et al. Auditory brainstem implants. Neurotherapeutics. Jan 2008;5(1):128-36. [Medline].
Gerszten PC, Burton SA, Ozhasoglu C, et al. Radiosurgery for benign intradural spinal tumors. Neurosurgery. Apr 2008;62(4):887-95; discussion 895-6. [Medline].
Aguiar PH, Tatagiba M, Samii M, et al. The comparison between the growth fraction of bilateral vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibular schwannomas using the monoclonal antibody MIB 1. Acta Neurochir (Wien). 1995;134(1-2):40-5. [Medline].
Baser M, MacCollin M, Sujansky E, et al. Malignant nervous system tumors in patients with neurofibromatosis 2. FASEB Summer Research Conference on Neurofibromatosis. 1996.
Briggs RJ, Brackmann DE, Baser ME, et al. Comprehensive management of bilateral acoustic neuromas. Current perspectives. Arch Otolaryngol Head Neck Surg. Dec 1994;120(12):1307-14. [Medline].
Epstein FJ, Farmer JP, Freed D. Adult intramedullary spinal cord ependymomas: the result of surgery in 38 patients. J Neurosurg. Aug 1993;79(2):204-9. [Medline].
Evans DG, Huson SM, Donnai D, et al. A clinical study of type 2 neurofibromatosis. Q J Med. Aug 1992;84(304):603-18. [Medline].
Evans DG, Huson SM, Donnai D, et al. A genetic study of type 2 neurofibromatosis in the United Kingdom. I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity. J Med Genet. Dec 1992;29(12):841-6. [Medline].
Hagel C, Lindenau M, Lamszus K, et al. Polyneuropathy in neurofibromatosis 2: clinical findings, molecular genetics and neuropathological alterations in sural nerve biopsy specimens. Acta Neuropathol (Berl). Aug 2002;104(2):179-87. [Medline].
Hoffman RA, Kohan D, Cohen NL. Cochlear implants in the management of bilateral acoustic neuromas. Am J Otol. Nov 1992;13(6):525-8. [Medline].
Kanowitz SJ, Shapiro WH, Golfinos JG, et al. Auditory brainstem implantation in patients with neurofibromatosis type 2. Laryngoscope. Dec 2004;114(12):2135-46. [Medline].
Kanter WR, Eldridge R, Fabricant R, et al. Central neurofibromatosis with bilateral acoustic neuroma: genetic, clinical and biochemical distinctions from peripheral neurofibromatosis. Neurology. Aug 1980;30(8):851-9. [Medline].
Kluwe L, Mautner V, Heinrich B, et al. Molecular study of frequency of mosaicism in neurofibromatosis 2 patients with bilateral vestibular schwannomas. J Med Genet. Feb 2003;40(2):109-14. [Medline].
Laszig R, Sollmann WP, Marangos N. The restoration of hearing in neurofibromatosis type 2. J Laryngol Otol. May 1995;109(5):385-9. [Medline].
Mautner VF, Lindenau M, Baser ME, et al. Skin abnormalities in neurofibromatosis 2. Arch Dermatol. Dec 1997;133(12):1539-43. [Medline].
Mautner VF, Tatagiba M, Guthoff R, et al. Neurofibromatosis 2 in the pediatric age group. Neurosurgery. Jul 1993;33(1):92-6. [Medline].
McCormick PC, Torres R, Post KD, et al. Intramedullary ependymoma of the spinal cord. J Neurosurg. Apr 1990;72(4):523-32. [Medline].
Ojemann RG. Management of acoustic neuromas (vestibular schwannomas) (honored guest presentation). Clin Neurosurg. 1993;40:498-535. [Medline].
Otto SR, Brackmann DE, Hitselberger W. Auditory brainstem implantation in 12- to 18-year-olds. Arch Otolaryngol Head Neck Surg. May 2004;130(5):656-9. [Medline].
Parry DM, Eldridge R, Kaiser-Kupfer MI, et al. Neurofibromatosis 2 (NF2): clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet. Oct 1 1994;52(4):450-61. [Medline].
Samii M, Matthies C. Management of 1000 vestibular schwannomas (acoustic neuromas): hearing function in 1000 tumor resections. Neurosurgery. Feb 1997;40(2):248-60; discussion 260-2. [Medline].
Selch MT, Pedroso A, Lee SP, et al. Stereotactic radiotherapy for the treatment of acoustic neuromas. J Neurosurg. Nov 2004;101 Suppl 3:362-72. [Medline].
Sobel RA. Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and in unilateral cases. J Neuropathol Exp Neurol. Mar 1993;52(2):106-13. [Medline].
Thomassin JM, Epron JP, Regis J, et al. Preservation of hearing in acoustic neuromas treated by gamma knife surgery. Stereotact Funct Neurosurg. Oct 1998;70 Suppl 1:74-9. [Medline].
Further Reading
Keywords
bilateral acoustic neurofibromatosis, bilateral acoustic neuroma, central neurofibromatosis, NF2, spinal cord tumor, spinal cord schwannoma, vestibular schwannoma, meningioma, multiple meningiomas, glioma, juvenile cataracts, neurofibromatosis type 2




















Multimedia: Neurofibromatosis, Type 2