Mobius Syndrome Medication

  • Author: Cheryl Ann Palmer, MD; Chief Editor: Amy Kao, MD   more...
 
Updated: Feb 23, 2012
 

Medication Summary

With few exceptions, pharmacologic intervention in patients with Möbius syndrome is used only for symptomatic treatment. As previously mentioned, patients with Möbius syndrome may be predisposed to infections, such as pulmonary infections resulting from aspiration pneumonia, and otitis media caused by structural anomalies of the ear. Vigilance and a low threshold for treatment are required. Antibiotics used in the treatment of infectious complications include amoxicillin and trimethoprim and sulfamethoxazole (TMP-SMZ).

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Antibiotics, Other

Class Summary

Proper antibiotic therapy should be started in the event of infections such as pneumonia or otitis media.

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Amoxicillin (Moxatag)

 

Amoxicillin is an ampicillin analogue with broad-spectrum bactericidal activity against many gram-positive and gram-negative organisms.

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Trimethoprim and sulfamethoxazole (Bactrim, Bactrim DS, Septra DS)

 

TMP-SMZ is a synthetic, broad-spectrum antibacterial combination. It inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA), inhibiting bacterial growth.

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Contributor Information and Disclosures
Author

Cheryl Ann Palmer, MD  Professor of Pathology and Neurology, Director, Neuropathology Fellowship Program, University of Alabama at Birmingham School of Medicine; Consulting Staff, Departments of Pathology and Neurology, University of Alabama at Birmingham Hospital; Consulting Staff, Departments of Pathology and Neurology, Veteran Affairs Medical Center; Consulting Staff, Department of Pathology, Children's Hospital of Alabama

Cheryl Ann Palmer, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuropathologists, Medical Association of the State of Alabama, Society for Neuro-Oncology, and Southern Medical Association

Disclosure: Nothing to disclose.

Chief Editor

Amy Kao, MD  Attending Neurologist, Children's National Medical Center

Amy Kao, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics, American Epilepsy Society, and Child Neurology Society

Disclosure: Nothing to disclose.

Additional Contributors

Robert J Baumann, MD Professor of Neurology and Pediatrics, Department of Neurology, University of Kentucky College of Medicine

Robert J Baumann, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics, and Child Neurology Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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Autopsy photograph of a 3-month-old child with Möbius syndrome who died unexpectedly demonstrates congenital amputation of the left hand at the wrist.
Low-power photomicrograph of a brainstem specimen in an infant with Möbius syndrome who died at age 3 months. Image shows bilateral lesions in the pons of the abducens nuclei (hematoxylin and eosin stain).
Medium-power photomicrograph from the abducens nucleus in an infant with Möbius syndrome who died demonstrates diffuse necrosis and neuronal loss (hematoxylin and eosin stain).
High-power photomicrograph shows a lesion of an abducens nerve nucleus in an infant with Möbius syndrome who died at age 3 months. Image shows neuronal loss, necrosis, myxoid change, and a circumferential rim of thickened glial fibrils (hematoxylin and eosin stain).
 
 
 
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