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Mobius Syndrome Medication

  • Author: Cheryl Ann Palmer, MD; Chief Editor: Amy Kao, MD  more...
Updated: Aug 09, 2016

Medication Summary

With few exceptions, pharmacologic intervention in patients with Möbius syndrome is used only for symptomatic treatment. As previously mentioned, patients with Möbius syndrome may be predisposed to infections, such as pulmonary infections resulting from aspiration pneumonia, and otitis media caused by structural anomalies of the ear. Vigilance and a low threshold for treatment are required. Antibiotics used in the treatment of infectious complications include amoxicillin and trimethoprim and sulfamethoxazole (TMP-SMZ).


Antibiotics, Other

Class Summary

Proper antibiotic therapy should be started in the event of infections such as pneumonia or otitis media.

Amoxicillin (Moxatag)


Amoxicillin is an ampicillin analogue with broad-spectrum bactericidal activity against many gram-positive and gram-negative organisms.

Trimethoprim and sulfamethoxazole (Bactrim, Bactrim DS, Septra DS)


TMP-SMZ is a synthetic, broad-spectrum antibacterial combination. It inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA), inhibiting bacterial growth.

Contributor Information and Disclosures

Cheryl Ann Palmer, MD Professor of Pathology, Director of Neuropathology, Director of Pathology Residency Program, Department of Pathology, Huntsman Cancer Institute, University of Utah School of Medicine

Cheryl Ann Palmer, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuropathologists, Society for Neuro-Oncology, International Society of Neuropathology

Disclosure: Nothing to disclose.

Chief Editor

Amy Kao, MD Attending Neurologist, Children's National Medical Center

Amy Kao, MD is a member of the following medical societies: American Academy of Neurology, American Epilepsy Society, Child Neurology Society

Disclosure: Have stock from Cellectar Biosciences; have stock from Varian medical systems; have stock from Express Scripts.


Robert J Baumann, MD Professor of Neurology and Pediatrics, Department of Neurology, University of Kentucky College of Medicine

Robert J Baumann, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics, and Child Neurology Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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Autopsy photograph of a 3-month-old child with Möbius syndrome who died unexpectedly demonstrates congenital amputation of the left hand at the wrist.
Low-power photomicrograph of a brainstem specimen in an infant with Möbius syndrome who died at age 3 months. Image shows bilateral lesions in the pons of the abducens nuclei (hematoxylin and eosin stain).
Medium-power photomicrograph from the abducens nucleus in an infant with Möbius syndrome who died demonstrates diffuse necrosis and neuronal loss (hematoxylin and eosin stain).
High-power photomicrograph shows a lesion of an abducens nerve nucleus in an infant with Möbius syndrome who died at age 3 months. Image shows neuronal loss, necrosis, myxoid change, and a circumferential rim of thickened glial fibrils (hematoxylin and eosin stain).
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