Moyamoya Disease Differential Diagnoses

  • Author: Roy Sucholeiki, MD; Chief Editor: Amy Kao, MD   more...
 
Updated: Jan 25, 2012
 
 

Diagnostic Considerations

Conditions to consider in the differential diagnosis of moyamoya disease include the following:

  • Homocystinuria/homocysteinemia
  • Hyperglycemia/hypoglycemia
  • Syndrome of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS)
  • Methylmalonic acidemia
  • Propionic acidemia
  • Neurofibromatosis, type 1
  • Neurofibromatosis, type 2
  • Pituitary tumors
  • Polyarteritis nodosa
  • Posterior cerebral artery stroke
  • Subarachnoid hemorrhage
  • Temporal/giant cell arteritis
  • Tolosa-Hunt syndrome
  • Apert syndrome
  • Aplastic anemia
  • Brainstem syndromes
  • Cranial trauma
  • Coarctation of the aorta
  • Fanconi anemia
  • Irradiation injury
  • Leptospirosis
  • Marfan syndrome
  • Mitochondrial cytopathies
  • Parasellar tumors
  • Sickle cell disease
  • Tuberculosis
  • Turner syndrome
  • Vasculitis
  • Carotid disease and stroke

Differential Diagnoses

Proceed to Workup
 
 
Contributor Information and Disclosures
Author

Roy Sucholeiki, MD  Director, Comprehensive Seizure and Epilepsy Program, The Neurosciences Institute at Central DuPage Hospital

Roy Sucholeiki, MD is a member of the following medical societies: American Academy of Neurology, American Epilepsy Society, and American Neuropsychiatric Association

Disclosure: Nothing to disclose.

Coauthor(s)

Jasvinder Chawla, MD, MBA  Chief of Neurology, Hines Veterans Affairs Hospital; Associate Professor and Director, Neurology Residency Training Program, Loyola University Medical Center

Jasvinder Chawla, MD, MBA is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Clinical Neurophysiology Society, and American Medical Association

Disclosure: Nothing to disclose.

Chief Editor

Amy Kao, MD  Attending Neurologist, Children's National Medical Center

Amy Kao, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics, American Epilepsy Society, and Child Neurology Society

Disclosure: Nothing to disclose.

Additional Contributors

Robert Stanley Rust Jr, MD, MA Thomas E Worrell Jr Professor of Epileptology and Neurology, Co-Director of FE Dreifuss Child Neurology and Epilepsy Clinics, Director, Child Neurology, University of Virginia; Chair-Elect, Child Neurology Section, American Academy of Neurology

Robert Stanley Rust Jr, MD, MA is a member of the following medical societies: American Academy of Neurology, American Epilepsy Society, American Headache Society, American Neurological Association, Child Neurology Society, International Child Neurology Association, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

References

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  2. Mineharu Y, Takenaka K, Yamakawa H, et al. Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting. J Neurol Neurosurg Psychiatry. Sep 2006;77(9):1025-9. [Medline].

  3. Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S, Takenaka K. Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology. Jun 10 2008;70(24 Pt 2):2357-63. [Medline].

  4. Kim SJ, Heo KG, Shin HY, Bang OY, Kim GM, Chung CS. Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study. Stroke. Jan 2010;41(1):173-6. [Medline].

  5. Im SH, Oh CW, Kwon OK, et al. Moyamoya disease associated with Graves disease: special considerations regarding clinical significance and management. J Neurosurg. Jun 2005;102(6):1013-7. [Medline].

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  7. Li H, Zhang ZS, Dong ZN, et al. Increased Thyroid Function and Elevated Thyroid Autoantibodies in Pediatric Patients With Moyamoya Disease: A Case-Control Study. Stroke. Feb 24 2011;[Medline].

  8. Starke RM, Komotar RJ, Hickman ZL, et al. Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease. Clinical article. J Neurosurg. Nov 2009;111(5):936-42. [Medline].

  9. Fung LW, Thompson D, Ganesan V. Revascularisation surgery for paediatric moyamoya: a review of the literature. Childs Nerv Syst. May 2005;21(5):358-64. [Medline].

  10. Scott RM, Smith JL, Robertson RL, et al. Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. J Neurosurg. Feb 2004;100(2 Suppl Pediatrics):142-9. [Medline].

  11. Hoffman HJ. Moyamoya disease and syndrome. Clin Neurol Neurosurg. Oct 1997;99 Suppl 2:S39-44. [Medline].

  12. Cohen N, Berant M, Simon J. Moyamoya and Fanconi's anemia. Pediatrics. Apr 1980;65(4):804-5. [Medline].

  13. Gosalakkal JA. Moyamoya disease: a review. Neurol India. Mar 2002;50(1):6-10. [Medline].

 
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Schematic representation of the circle of Willis, arteries of the brain, and brain stem.
 
 
 
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