eMedicine Specialties > Neurology > Seizures and Epilepsy
Frontal Lobe Epilepsy: Follow-up
Updated: May 7, 2009
Follow-up
Further Outpatient Care
- Patients require frequent office visits during the titration and adjustment phase of anticonvulsants.
- Examination should include evaluation for excessive nystagmus, tremor, and ataxia.
- Baseline and follow-up blood testing may be needed.
- When seizure free on maintenance dose of medication, patients may be asked to come for follow-up 1-3 times a year.
- Patients who are seizure free for 2-5 years may be considered for a trial of medication withdrawal, depending on the individual case.
Inpatient & Outpatient Medications
Folate should be added to the anticonvulsant regimen of female patients of childbearing age.
Deterrence/Prevention
- Frontal lobe epilepsy may be an early or late aftermath of head trauma. Measures should be taken to prevent head injury, including mandatory use of seat belts and bicycle helmets.
- Use of prophylactic anticonvulsants following head trauma has not demonstrated a decrease in the development of epilepsy.
Complications
- Status epilepticus - This is reported in up to 25% of patients with frontal lobe epilepsy. The episodes may be convulsive, nonconvulsive, or simple partial.
- Comorbid psychiatric or behavioral disturbance
Prognosis
- Approximately 65-75% of patients with frontal lobe seizures respond to appropriate anticonvulsants and become seizure free.
- The proportion of patients with medically refractory frontal lobe epilepsy who become seizure free from additional medications or surgical options is lower than in patients with temporal lobe epilepsy.
- An important feature in prognosis is the early recognition of frontal lobe seizures as an epileptic syndrome rather than a parasomnia or psychiatric condition.
Patient Education
- Patient education is important for all patients with epilepsy. Many patients benefit from joining one of the national or regional epilepsy support groups.
- Quality of life issues
- "Stigma" of epilepsy
- Living with restrictions
- Living with long-term medical therapy
Miscellaneous
Medicolegal Pitfalls
- Failure to diagnose the episodes as epilepsy, misdiagnosis as a psychiatric or parasomniac condition
- Driving restrictions
- Certain states have mandatory reporting of seizures by physicians to the motor vehicle authorities (eg, Department of Motor Vehicles [DMV]).
- Even in states that do not have mandatory reporting, physicians must document that the patient is aware of driving restrictions.
- Patients must be aware of the potential risks of pregnancy and epilepsy/anticonvulsants. Women of childbearing age who are taking anticonvulsants should be given folate supplementation.
More on Frontal Lobe Epilepsy |
| Overview: Frontal Lobe Epilepsy |
| Differential Diagnoses & Workup: Frontal Lobe Epilepsy |
| Treatment & Medication: Frontal Lobe Epilepsy |
Follow-up: Frontal Lobe Epilepsy |
| References |
| « Previous Page |
References
O'Brien TJ, Mosewich RK, Britton JW, Cascino GD, So EL. History and seizure semiology in distinguishing frontal lobe seizures and temporal lobe seizures. Epilepsy Res. Dec 2008;82(2-3):177-82. [Medline].
Williamson PD, Spencer DD, Spencer SS, Novelly RA, Mattson RH. Complex partial seizures of frontal lobe origin. Ann Neurol. Oct 1985;18(4):497-504. [Medline].
Laskowitz DT, Sperling MR, French JA, O'Connor MJ. The syndrome of frontal lobe epilepsy: characteristics and surgical management. Neurology. Apr 1995;45(4):780-7. [Medline].
So NK. Mesial frontal epilepsy. Epilepsia. 1998;39 Suppl 4:S49-61. [Medline].
Kotagal P, Arunkumar GS. Lateral frontal lobe seizures. Epilepsia. 1998;39 Suppl 4:S62-8. [Medline].
Scheffer IE. Autosomal dominant nocturnal frontal lobe epilepsy. Epilepsia. Aug 2000;41(8):1059-60. [Medline].
Steinlein OK. Nicotinic receptor mutations in human epilepsy. Prog Brain Res. 2004;145:275-85. [Medline].
Picard F, Bruel D, Servent D, et al. Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study. Brain. Aug 2006;129(Pt 8):2047-60. [Medline].
Brodtkorb E, Picard F. Tobacco habits modulate autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy Behav. Nov 2006;9(3):515-520. [Medline].
Fedi M, Berkovic SF, Scheffer IE, O'Keefe G, Marini C, Mulligan R, et al. Reduced striatal D1 receptor binding in autosomal dominant nocturnal frontal lobe epilepsy. Neurology. Sep 9 2008;71(11):795-8. [Medline].
Knake S, Triantafyllou C, Wald LL, Wiggins G, Kirk GP, Larsson PG, et al. 3T phased array MRI improves the presurgical evaluation in focal epilepsies: a prospective study. Neurology. Oct 11 2005;65(7):1026-31. [Medline].
Bonelli SB, Lurger S, Zimprich F, Stogmann E, Assem-Hilger E, Baumgartner C. Clinical seizure lateralization in frontal lobe epilepsy. Epilepsia. Mar 2007;48(3):517-23. [Medline].
Mosewich RK, So EL, O'Brien TJ, Cascino GD, Sharbrough FW, Marsh WR, et al. Factors predictive of the outcome of frontal lobe epilepsy surgery. Epilepsia. Jul 2000;41(7):843-9. [Medline].
Elsharkawy AE, Alabbasi AH, Pannek H, Schulz R, Hoppe M, Pahs G, et al. Outcome of frontal lobe epilepsy surgery in adults. Epilepsy Res. Oct 2008;81(2-3):97-106. [Medline].
Jeha LE, Najm I, Bingaman W, Dinner D, Widdess-Walsh P, Lüders H. Surgical outcome and prognostic factors of frontal lobe epilepsy surgery. Brain. Feb 2007;130:574-84. [Medline].
Kossoff EH, Rowley H, Sinha SR, Vining EP. A prospective study of the modified Atkins diet for intractable epilepsy in adults. Epilepsia. Feb 2008;49(2):316-9. [Medline].
Benedek K, Juhasz C, Muzik O, et al. Metabolic changes of subcortical structures in intractable focal epilepsy. Epilepsia. Sep 2004;45(9):1100-5. [Medline].
Combi R, Dalpra L, Tenchini ML, Ferini-Strambi L. Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview. J Neurol. Aug 2004;251(8):923-34. [Medline].
Hosking PG. Surgery for frontal lobe epilepsy. Seizure. Apr 2003;12(3):160-6. [Medline].
Westmoreland BF. The EEG findings in extratemporal seizures. Epilepsia. 1998;39 Suppl 4:S1-8. [Medline].
Further Reading
Keywords
frontal lobe epilepsy, supplementary motor area seizures, primary motor cortex seizures, medial frontal seizures, cingulate gyrus seizures, orbitofrontal seizures, frontopolar seizures, dorsolateral cortex seizures, operculum seizures, seizure treatment, epilepsy treatment
Follow-up: Frontal Lobe Epilepsy