Sudden Unexpected Death in Epilepsy: Multimedia

References

1. Zielinski JJ. Epilepsy and mortality rate and cause of death. Epilepsia. Jun 1974;15(2):191-201. [Medline].

2. Cockerell OC, Johnson AL, Sander JW, Hart YM, Goodridge DM, Shorvon SD. Mortality from epilepsy: results from a prospective population-based study. Lancet. Oct 1 1994;344(8927):918-21. [Medline].

3. Olafsson E, Hauser WA, Gudmundsson G. Long-term survival of people with unprovoked seizures: a population-based study. Epilepsia. Jan 1998;39(1):89-92. [Medline].

4. Loiseau J, Picot MC, Loiseau P. Short-term mortality after a first epileptic seizure: a population-based study. Epilepsia. Oct 1999;40(10):1388-92. [Medline].

5. Lindsten H, Nyström L, Forsgren L. Mortality risk in an adult cohort with a newly diagnosed unprovoked epileptic seizure: a population-based study. Epilepsia. Nov 2000;41(11):1469-73. [Medline].

6. Lhatoo SD, Sander JW. Cause-specific mortality in epilepsy. Epilepsia. 2005;46 Suppl 11:36-9. [Medline].

7. Lathers CM, Schraeder PL. Verbal autopsies and SUDEP. Epilepsy Behav. Apr 2009;14(4):573-6. [Medline].

8. Kloster R, Engelskjon T. Sudden unexpected death in epilepsy (SUDEP): a clinical perspective and a search for risk factors. J Neurol Neurosurg Psychiatry. Oct 1999;67(4):439-44. [Medline].

9. Earnest MP, Thomas GE, Eden RA, et al. The sudden unexplained death syndrome in epilepsy: demographic, clinical, and postmortem features. Epilepsia. Mar-Apr 1992;33(2):310-6. [Medline].

10. Terrence CF, Rao GR, Perper JA. Neurogenic pulmonary edema in unexpected, unexplained death of epileptic patients. Ann Neurol. May 1981;9(5):458-64. [Medline].

11. Langan Y, Nashef L, Sander JW. Case-control study of SUDEP. Neurology. Apr 12 2005;64(7):1131-3. [Medline].

12. Leestma JE, Annegers JF, Brodie MJ, et al. Sudden unexplained death in epilepsy: observations from a large clinical development program. Epilepsia. Jan 1997;38(1):47-55. [Medline].

13. Johnston SC, Horn JK, Valente J, et al. The role of hypoventilation in a sheep model of epileptic sudden death. Ann Neurol. Apr 1995;37(4):531-7. [Medline].

14. So EL, Sam MC, Lagerlund TL. Postictal central apnea as a cause of SUDEP: evidence from near-SUDEP incident. Epilepsia. Nov 2000;41(11):1494-7. [Medline].

15. Tavee J, Morris H 3rd. Severe postictal laryngospasm as a potential mechanism for sudden unexpected death in epilepsy: a near-miss in an EMU. Epilepsia. Dec 2008;49(12):2113-7. [Medline].

16. Jackson JH, Beevor CE. Sudden Unexpected Death in Epilepsy. Brain. 1889;12:346.

17. Erickson T. Cardiac activity during epileptic seizure. Arch Neurol Psych. 1939;41:511-518.

18. Nei M, Ho RT, Abou-Khalil BW. EEG and ECG in sudden unexplained death in epilepsy. Epilepsia. Apr 2004;45(4):338-45. [Medline].

19. Williams J, Lawthom C, Dunstan FD, Dawson TP, Kerr MP, Wilson JF, et al. Variability of antiepileptic medication taking behaviour in sudden unexplained death in epilepsy: hair analysis at autopsy. J Neurol Neurosurg Psychiatry. Apr 2006;77(4):481-4. [Medline].

20. Devinsky O, Price BH, Cohen SI. Cardiac manifestations of complex partial seizures. Am J Med. Feb 1986;80(2):195-202. [Medline].

21. Kenneback G, Ericson M, Tomson T, et al. Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death. Seizure. Oct 1997;6(5):369-75. [Medline].

22. Tellez-Zenteno JF, Ronquillo LH, Wiebe S. Sudden unexpected death in epilepsy: evidence-based analysis of incidence and risk factors. Epilepsy Res. Jun 2005;65(1-2):101-15. [Medline].

23. Mohanraj R, Norrie J, Stephen LJ, Kelly K, Hitiris N, Brodie MJ. Mortality in adults with newly diagnosed and chronic epilepsy: a retrospective comparative study. Lancet Neurol. Jun 2006;5(6):481-7. [Medline].

24. Vlooswijk MC, Majoie HJ, De Krom MC, Tan IY, Aldenkamp AP. SUDEP in the Netherlands: a retrospective study in a tertiary referral center. Seizure. Mar 2007;16(2):153-9. [Medline].

25. Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol. Nov 2008;7(11):1021-31. [Medline].

26. Ficker DM, So EL, Shen WK, et al. Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology. Nov 1998;51(5):1270-4. [Medline].

27. Neuspiel DR, Kuller LH. Sudden and unexpected natural death in childhood and adolescence. JAMA. Sep 13 1985;254(10):1321-5. [Medline].

28. Donner EJ, Smith CR, Snead OC 3rd. Sudden unexplained death in children with epilepsy. Neurology. Aug 14 2001;57(3):430-4. [Medline].

29. Hitiris N, Suratman S, Kelly K, Stephen LJ, Sills GJ, Brodie MJ. Sudden unexpected death in epilepsy: a search for risk factors. Epilepsy Behav. Feb 2007;10(1):138-41. [Medline].

30. Callenbach PM, Westendorp RG, Geerts AT, Arts WF, Peeters EA, van Donselaar CA, et al. Mortality risk in children with epilepsy: the Dutch study of epilepsy in childhood. Pediatrics. Jun 2001;107(6):1259-63. [Medline].

31. Sperling MR, Feldman H, Kinman J, et al. Seizure control and mortality in epilepsy. Ann Neurol. Jul 1999;46(1):45-50. [Medline].

32. Morton B, Richardson A, Duncan S. Sudden unexpected death in epilepsy (SUDEP): don't ask, don't tell?. J Neurol Neurosurg Psychiatry. Feb 2006;77(2):199-202. [Medline].

33. Beran RG, Weber S, Sungaran R, Venn N, Hung A. Review of the legal obligations of the doctor to discuss Sudden Unexplained Death in Epilepsy (SUDEP)--a cohort controlled comparative cross-matched study in an outpatient epilepsy clinic. Seizure. Oct 2004;13(7):523-8. [Medline].

34. Nashef L, Garner S, Sander JW, et al. Circumstances of death in sudden death in epilepsy: interviews of bereaved relatives. J Neurol Neurosurg Psychiatry. Mar 1998;64(3):349-52. [Medline].

35. Annegers JF, Coan SP. SUDEP: overview of definitions and review of incidence data. Seizure. Sep 1999;8(6):347-52. [Medline].

36. Ansakorpi H, Korpelainen JT, Suominen K, et al. Interictal cardiovascular autonomic responses in patients with temporal lobe epilepsy. Epilepsia. Jan 2000;41(1):42-7. [Medline].

37. Bacon GM. On the modes of death in epilepsy. Lancet. 1868;1:555-6.

38. Blumhardt LD, Smith PE, Owen L. Electrocardiographic accompaniments of temporal lobe epileptic seizures. Lancet. May 10 1986;1(8489):1051-6. [Medline].

39. Camfield CS, Camfield PR. Good news-a population based study indicates that SUDEP is very unusual in childhood onset epilepsy. Epilepsia. 1999;40(Suppl 7):159.

40. Camfield P, Camfield C. Sudden unexpected death in people with epilepsy: a pediatric perspective. Semin Pediatr Neurol. Mar 2005;12(1):10-4. [Medline].

41. Cockerell OC. The mortality of epilepsy. Curr Opin Neurol. Apr 1996;9(2):93-6. [Medline].

42. Day SM, Wu YW, Strauss DJ. Causes of death in remote symptomatic epilepsy. Neurology. Jul 26 2005;65(2):216-22. [Medline].

43. Devinsky O, Pacia S, Tatambhotla G. Bradycardia and asystole induced by partial seizures: a case report and literature review. Neurology. Jun 1997;48(6):1712-4. [Medline].

44. Drake ME Jr, Andrews JM, Castleberry CM. Electrophysiologic assessment of autonomic function in epilepsy. Seizure. Apr 1998;7(2):91-6. [Medline].

45. George JR, Davis GG. Comparison of anti-epileptic drug levels in different cases of sudden death. J Forensic Sci. May 1998;43(3):598-603. [Medline].

46. Hennessy MJ, Langan Y, Elwes RD, et al. A study of mortality after temporal lobe epilepsy surgery. Neurology. Oct 12 1999;53(6):1276-83. [Medline].

47. Hitiris N, Mohanraj R, Norrie J, Brodie MJ. Mortality in epilepsy. Epilepsy Behav. May 2007;10(3):363-76. [Medline].

48. Isojarvi JI, Ansakorpi H, Suominen K, et al. Interictal cardiovascular autonomic responses in patients with epilepsy. Epilepsia. Apr 1998;39(4):420-6. [Medline].

49. Langan Y, Nashef L, Sander JW. Sudden unexpected death in epilepsy: a series of witnessed deaths. J Neurol Neurosurg Psychiatry. Feb 2000;68(2):211-3. [Medline].

50. Lathers CM, Schraeder PL, Weiner FL. Synchronization of cardiac autonomic neural discharge with epileptogenic activity: the lockstep phenomenon. Electroencephalogr Clin Neurophysiol. Sep 1987;67(3):247-59. [Medline].

51. Lear-Kaul KC, Coughlin L, Dobersen MJ. Sudden unexpected death in epilepsy: a retrospective study. Am J Forensic Med Pathol. Mar 2005;26(1):11-7. [Medline].

52. Lim EC, Lim SH, Wilder-Smith E. Brain seizes, heart ceases: a case of ictal asystole. J Neurol Neurosurg Psychiatry. Oct 2000;69(4):557-9. [Medline].

53. Lip GY, Brodie MJ. Sudden death in epilepsy: an avoidable outcome?. J R Soc Med. Oct 1992;85(10):609-11. [Medline].

54. Massetani R, Strata G, Galli R, et al. Alteration of cardiac function in patients with temporal lobe epilepsy: different roles of EEG-ECG monitoring and spectral analysis of RR variability. Epilepsia. Mar 1997;38(3):363-9. [Medline].

55. Monté CP, Arends JB, Tan IY, Aldenkamp AP, Limburg M, de Krom MC. Sudden unexpected death in epilepsy patients: Risk factors. A systematic review. Seizure. Jan 2007;16(1):1-7. [Medline].

56. Nashef L, Walker F, Allen P, et al. Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy. J Neurol Neurosurg Psychiatry. Mar 1996;60(3):297-300. [Medline].

57. Nei M, Ho RT, Sperling MR. EKG abnormalities during partial seizures in refractory epilepsy. Epilepsia. May 2000;41(5):542-8. [Medline].

58. Nilsson L, Ahlbom A, Farahmand BY, Tomson T. Mortality in a population-based cohort of epilepsy surgery patients. Epilepsia. Apr 2003;44(4):575-81. [Medline].

59. Nilsson L, Bergman U, Diwan V. Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study. Epilepsia. May 2001;42(5):667-73. [Medline].

60. Nilsson L, Farahmand BY, Persson PG, et al. Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet. Mar 13 1999;353(9156):888-93. [Medline].

61. Nilsson L, Tomson T, Farahmand BY, et al. Cause-specific mortality in epilepsy: a cohort study of more than 9,000 patients once hospitalized for epilepsy. Epilepsia. Oct 1997;38(10):1062-8. [Medline].

62. Novak V, Reeves AL, Novak P, et al. Time-frequency mapping of R-R interval during complex partial seizures of temporal lobe origin. J Auton Nerv Syst. Sep 24 1999;77(2-3):195-202. [Medline].

63. Opeskin K, Harvey AS, Cordner SM, et al. Sudden unexpected death in epilepsy in Victoria. J Clin Neurosci. Jan 2000;7(1):34-7. [Medline].

64. Opeskin K, Thomas A, Berkovic SF. Does cardiac conduction pathology contribute to sudden unexpected death in epilepsy?. Epilepsy Res. Jun 2000;40(1):17-24. [Medline].

65. Schernthaner C, Lindinger G, Potzelberger K, et al. Autonomic epilepsy--the influence of epileptic discharges on heart rate and rhythm. Wien Klin Wochenschr. May 21 1999;111(10):392-401. [Medline].

66. Schraeder PL, Delin K, McClelland RL. Coroner and medical examiner documentation of sudden unexplained deaths in epilepsy. Epilepsy Res. Feb 2006;68(2):137-43. [Medline].

67. Schraeder PL, Lathers CM. Paroxysmal autonomic dysfunction, epileptogenic activity and sudden death. Epilepsy Res. Jan-Feb 1989;3(1):55-62. [Medline].

68. Smith WS, Matthay MA. Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest. May 1997;111(5):1326-33. [Medline].

69. So EL. Demystifying sudden unexplained death in epilepsy--are we close?. Epilepsia. 2006;47 Suppl 1:87-92. [Medline].

70. Stollberger C, Finsterer J. Cardiorespiratory findings in sudden unexplained/unexpected death in epilepsy (SUDEP). Epilepsy Res. Mar 2004;59(1):51-60. [Medline].

71. Tennis P, Cole TB, Annegers JF, et al. Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with antiepileptic drugs in Saskatchewan, Canada. Epilepsia. Jan 1995;36(1):29-36. [Medline].

72. Thom M, Griffin B, Sander JW, et al. Amygdala sclerosis in sudden and unexpected death in epilepsy. Epilepsy Res. Oct 1999;37(1):53-62. [Medline].

73. Thom M, Seetah S, Sisodiya S, Koepp M, Scaravilli F. Sudden and unexpected death in epilepsy (SUDEP): evidence of acute neuronal injury using HSP-70 and c-Jun immunohistochemistry. Neuropathol Appl Neurobiol. Apr 2003;29(2):132-43. [Medline].

74. Timmings PL. Sudden unexpected death in epilepsy: is carbamazepine implicated?. Seizure. Aug 1998;7(4):289-91. [Medline].

75. Tomson T. Mortality in epilepsy. J Neurol. Jan 2000;247(1):15-21. [Medline].

76. Tomson T, Ericson M, Ihrman C, et al. Heart rate variability in patients with epilepsy. Epilepsy Res. Mar 1998;30(1):77-83. [Medline].

77. Tomson T, Walczak T, Sillanpaa M. Sudden unexpected death in epilepsy: a review of incidence and risk factors. Epilepsia. 2005;46 Suppl 11:54-61. [Medline].

78. Téllez-Zenteno JF, Ronquillo LH, Wiebe S. Sudden unexpected death in epilepsy: evidence-based analysis of incidence and risk factors. Epilepsy Res. Jun 2005;65(1-2):101-15. [Medline].

79. Walczak T. Do antiepileptic drugs play a role in sudden unexpected death in epilepsy?. Drug Saf. 2003;26(10):673-83. [Medline].

80. Walczak TS, Leppik IE, D'Amelio M, Rarick J, So E, Ahman P, et al. Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology. Feb 27 2001;56(4):519-25. [Medline].

81. Walczak TS, Leppik IE, D'Amelio M, Rarick J, So E, Ahman P. Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology. Feb 27 2001;56(4):519-25. [Medline].

82. Walker F, Fish DR. Recording respiratory parameters in patients with epilepsy. Epilepsia. 1997;38(Suppl 11):41-42.

83. Weber P, Bubl R, Blauenstein U. Sudden unexplained death in children with epilepsy: A cohort study with an eighteen-year follow-up. Acta Paediatr. May 2005;94(5):564-7. [Medline].

Further Reading

Keywords

epilepsy death, SUDEP, antiepileptic medication, antiepileptic drugs, AEDs, cardiac arrhythmia, pulmonary edema, unexpected seizure, apnea, sudden unexpected death in epilepsy, epilepsy, epilepsy-related death

Contributor Information and Disclosures

Author

Shahin Nouri, MD, Director, Comprehensive Epilepsy Center, Associate Chief, Division of Neurology, New York Methodist Hospital
Shahin Nouri, MD is a member of the following medical societies: American Academy of Neurology and American Epilepsy Society
Disclosure: UCB Honoraria Speaking and teaching; Pfizer Honoraria Speaking and teaching

Coauthor(s)

Marshall Balish, MD, PhD, Assistant Chairman, Assistant Professor, Department of Neurology, Washington Veterans Affairs Medical Center, Georgetown University
Disclosure: Nothing to disclose.

Medical Editor

Erasmo A Passaro, MD, Director, Comprehensive Epilepsy Program/Clinical Neurophysiology Lab, Bayfront Medical Center Florida Center for Neurology
Erasmo A Passaro, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, American Medical Association, and American Society of Neuroimaging
Disclosure: Glaxo Smith Kline Honoraria Speaking and teaching; UCB Honoraria Speaking and teaching; Pfizer Honoraria Speaking and teaching; Takeda Honoraria Speaking and teaching

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Jose E Cavazos, MD, PhD, FAAN, Associate Professor with Tenure, Departments of Neurology, Pharmacology, and Physiology, University of Texas Health Science Center at San Antonio; Co-Director, South Texas Comprehensive Epilepsy Center; Director of the Epilepsy Center, Audie L Murphy Veterans Affairs Medical Center
Jose E Cavazos, MD, PhD, FAAN is a member of the following medical societies: American Academy of Neurology, American Clinical Neurophysiology Society, American Epilepsy Society, and Society for Neuroscience
Disclosure: Nothing to disclose.

CME Editor

Selim R Benbadis, MD, Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, University of South Florida School of Medicine, Tampa General Hospital
Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Selim R Benbadis, MD, Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, University of South Florida School of Medicine, Tampa General Hospital
Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association
Disclosure: Nothing to disclose.