Glucagonoma Differential Diagnoses

  • Author: Luigi Santacroce, MD; Chief Editor: George T Griffing, MD   more...
 
Updated: May 23, 2011
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Luigi Santacroce, MD  Assistant Professor, Medical School, State University at Bari, Italy

Disclosure: Nothing to disclose.

Coauthor(s)

Laura Diomede  University of Bari School of Medicine, Italy

Disclosure: Nothing to disclose.

Mini R Abraham, MD  Consulting Staff, Overland Park Medical Specialists

Mini R Abraham, MD is a member of the following medical societies: American Association of Clinical Endocrinologists and Endocrine Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Frederick H Ziel, MD  Associate Professor of Medicine, David Geffen School of Medicine at UCLA; Physician-In-Charge, Endocrinology/Diabetes Center, Director of Medical Education, Kaiser Permanente Woodland Hills; Chair of Endocrinology, Co-Chair of Diabetes Complete Care Program, Southern California Permanente Medical Group

Frederick H Ziel, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Endocrinology, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Diabetes Association, American Federation for Medical Research, American Medical Association, American Society for Bone and Mineral Research, California Medical Association, Endocrine Society, and International Society for Clinical Densitometry

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: eMedicine Salary Employment

Romesh Khardori, MD, PhD, FACP  Former Professor, Department of Medicine, Former Chief, Division of Endocrinology, Metabolism, and Molecular Medicine, Southern Illinois University School of Medicine

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, and Endocrine Society

Disclosure: Nothing to disclose.

Mark Cooper, MBBS, PhD, FRACP  Head, Diabetes & Metabolism Division, Baker Heart Research Institute, Professor of Medicine, Monash University

Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD  Professor of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Medical Practice Executives, American College of Physician Executives, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical Research, Endocrine Society, International Society for Clinical Densitometry, and Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

References

  1. McGavran MH, Unger RH, Recant L, et al. A glucagon-secreting alpha-cell carcinoma of the pancreas. N Engl J Med. Jun 23 1966;274(25):1408-13. [Medline].

  2. Pujol RM, Wang CY, el-Azhary RA, et al. Necrolytic migratory erythema: clinicopathologic study of 13 cases. Int J Dermatol. Jan 2004;43(1):12-8. [Medline].

  3. Remes-Troche JM, Garcia-de-Acevedo B, Zuniga-Varga J, et al. Necrolytic migratory erythema: a cutaneous clue to glucagonoma syndrome. J Eur Acad Dermatol Venereol. Sep 2004;18(5):591-5. [Medline].

  4. el Darouty M, Abu el Ela M. Necrolytic migratory erythema without glucagonoma in patients with liver disease. J Am Acad Dermatol. Jun 1996;34(6):1092-3. [Medline].

  5. Nakashima H, Komine M, Sasaki K, et al. Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome. J Dermatol. Aug 2006;33(8):557-62. [Medline].

  6. Yao JC, Eisner MP, Leary C, et al. Population-based study of islet cell carcinoma. Ann Surg Oncol. Dec 2007;14(12):3492-500. [Medline]. [Full Text].

  7. Xu Q, Chen WH, Huang QJ. Spiral CT localization of pancreatic functioning islet cell tumors. Hepatobiliary Pancreat Dis Int. Nov 2004;3(4):616-9. [Medline].

  8. Melen-Mucha G, Lawnicka H, Kierszniewska-Stepien D, et al. The place of somatostatin analogs in the diagnosis and treatment of the neuoroendocrine glands tumors. Recent Patents Anticancer Drug Discov. Jun 2006;1(2):237-54. [Medline].

  9. Kindmark H, Sundin A, Granberg D, et al. Endocrine pancreatic tumors with glucagon hypersecretion: a retrospective study of 23 cases during 20 years. Med Oncol. 2007;24(3):330-7. [Medline].

  10. O'Grady HL, Conlon KC. Pancreatic neuroendocrine tumours. Eur J Surg Oncol. Mar 2008;34(3):324-32. [Medline].

  11. Moattari AR, Cho K, Vinik AI. Somatostatin analogue in treatment of coexisting glucagonoma and pancreatic pseudocyst: dissociation of responses. Surgery. Sep 1990;108(3):581-7. [Medline].

  12. Tomassetti P, Migliori M, Corinaldesi R, et al. Treatment of gastroenteropancreatic neuroendocrine tumours with octreotide LAR. Aliment Pharmacol Ther. May 2000;14(5):557-60. [Medline].

  13. [Best Evidence] Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. Feb 10 2011;364(6):514-23. [Medline].

  14. Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. Feb 10 2011;364(6):501-13. [Medline].

  15. Pautrat K, Bretagnol F, de Muret A, et al. [Recurrent glucagonoma 20 years after surgical resection]. Gastroenterol Clin Biol. Dec 2003;27(12):1163-5. [Medline].

  16. Akerstrom G, Hellman P, Hessman O, et al. Surgical treatment of endocrine pancreatic tumours. Neuroendocrinology. 2004;80 Suppl 1:62-6. [Medline].

  17. Clouse ME, Perry L, Stuart K, et al. Hepatic arterial chemoembolization for metastatic neuroendocrine tumors. Digestion. 1994;55 Suppl 3:92-7. [Medline].

  18. King J, Quinn R, Glenn DM, et al. Radioembolization with selective internal radiation microspheres for neuroendocrine liver metastases. Cancer. Sep 1 2008;113(5):921-9. [Medline].

  19. Radny P, Eigentler TK, Soennichsen K, et al. Metastatic glucagonoma: treatment with liver transplantation. J Am Acad Dermatol. Feb 2006;54(2):344-7. [Medline].

  20. Montenegro F, Lawrence GD, Macon W, et al. Metastatic glucagonoma. Improvement after surgical debulking. Am J Surg. Mar 1980;139(3):424-7. [Medline].

  21. Fernández-Cruz L, Blanco L, Cosa R, Rendón H. Is laparoscopic resection adequate in patients with neuroendocrine pancreatic tumors?. World J Surg. May 2008;32(5):904-17. [Medline].

  22. Adam DN, Cohen PD, Ghazarian D. Necrolytic migratory erythema: case report and clinical review. J Cutan Med Surg. Jul-Aug 2003;7(4):333-8. [Medline].

  23. Baton O, Eggenspieller P, Bechade D, et al. [Median pancreatectomy for early glucagonoma]. Gastroenterol Clin Biol. Mar 2005;29(3):308-10. [Medline].

  24. Bhathena SJ, Higgins GA, Recant L. Glucagonoma and glucagonoma syndrome. In: Unger RH, Orci L, eds. Glucagon. New York, NY: Elsevier Science; 1981:413.

  25. Cruz-Bautista I, Lerman I, Perez-Enriquez B, et al. Diagnostic challenge of glucagonoma: case report and literature review. Endocr Pract. Jul-Aug 2006;12(4):422-6. [Medline].

  26. Du Jardin P, Cools P, Van der Stighelen Y. Necrolytic migratory erythema: first symptom of a glucagonoma. A case report. Acta Chir Belg. Aug 2004;104(4):468-70. [Medline].

  27. Echenique-Elizondo M, Elorza JL, De Delas JS. Migratory necrolytic erythema and glucagonoma. Surgery. Apr 2003;133(4):449-50. [Medline].

  28. Grant CS. Surgical management of malignant islet cell tumors. World J Surg. Jul-Aug 1993;17(4):498-503. [Medline].

  29. Jabbour SA, Davidovici BB, Wolf R. Rare syndromes. Clin Dermatol. Jul-Aug 2006;24(4):299-316. [Medline].

  30. Koike N, Hatori T, Imaizumi T, et al. Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus. J Hepatobiliary Pancreat Surg. 2003;10(1):101-5. [Medline].

  31. Kovács RK, Korom I, Dobozy A, et al. Necrolytic migratory erythema. J Cutan Pathol. Mar 2006;33(3):242-5. [Medline].

  32. Krause W. Skin diseases in consequence of endocrine alterations. Aging Male. Jun 2006;9(2):81-95. [Medline].

  33. Marko PB, Miljkovic J, Zemljic TG. Necrolytic migratory erythema associated with hyperglucagonemia and neuroendocrine hepatic tumors. Acta Dermatovenerol Alp Panonica Adriat. Dec 2005;14(4):161-4, 166. [Medline]. [Full Text].

  34. Moertel CG, Johnson CM, McKusick MA, et al. The management of patients with advanced carcinoid tumors and islet cell carcinomas. Ann Intern Med. Feb 15 1994;120(4):302-9. [Medline].

  35. Schanz S, Schaefer J, Fierlbeck G. Glucagonoma presenting with necrolytic migratory erythema: the glucagonoma syndrome. Gastroenterology. Dec 2005;129(6):1816, 2131. [Medline].

  36. Tomita T, Masuzaki H, Noguchi M, et al. GPR40 gene expression in human pancreas and insulinoma. Biochem Biophys Res Commun. Dec 30 2005;338(4):1788-90. [Medline].

  37. Vinik AI, Perry RR. Neoplasms of the gastroenteropancreatic endocrine system. In: Holland JF, Frei E III, Bast RC Jr, et al, eds. Cancer Medicine. 4th ed. Baltimore, Md: William & Wilkins; 1997.

  38. Wang L, Zhao YP, Lee CI, et al. Diagnosis and treatment of malignant pancreatic endocrine tumour. Chin Med Sci J. Jun 2004;19(2):130-3. [Medline].

  39. Zhang M, Xu X, Shen Y, et al. Clinical experience in diagnosis and treatment of glucagonoma syndrome. Hepatobiliary Pancreat Dis Int. Aug 2004;3(3):473-5. [Medline].

 
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A section of a glucagonoma mass with several fiber bundles and solid cellular strands (125 X). Courtesy of Professor Pantaleo Bufo, University of Foggia, Italy.
A section of a glucagonoma mass with irregular aspects of fiber bundles and cellular strands (400 X). Courtesy of Professor Pantaleo Bufo, University of Foggia, Italy.
 
 
 
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