eMedicine Specialties > Ophthalmology > Choroid

Angioid Streaks: Multimedia

Author: Mohammad Abusamak, MD, Chief Retina Division, Assistant Professor, Division of Ophthalmology, Jordan University Hospital
Contributor Information and Disclosures

Updated: Oct 16, 2008

Multimedia

Red-free photograph of the optic nerve and poster...
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Media file 1: Red-free photograph of the optic nerve and posterior pole showing the cracks in the Bruch membrane. Notice the retinal arteries and veins crossing over the dark red streaks.
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Red-free photograph of the optic nerve and poster...

Red-free photograph of the optic nerve and posterior pole showing the cracks in the Bruch membrane. Notice the retinal arteries and veins crossing over the dark red streaks.

Early fluorescein angiography showing the early h...
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Media file 2: Early fluorescein angiography showing the early hyperfluorescence, window defect, of the angioid streaks.
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Early fluorescein angiography showing the early h...

Early fluorescein angiography showing the early hyperfluorescence, window defect, of the angioid streaks.

Late fluorescein angiography of the same eye as i...
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Media file 3: Late fluorescein angiography of the same eye as in Media file 2. Notice the staining of the edges of the streaks. Also, staining in the center of the macula is present due to extension of the Bruch membrane crack. When compared to early fluorescein angiography, no active leakage is present.
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Late fluorescein angiography of the same eye as i...

Late fluorescein angiography of the same eye as in Media file 2. Notice the staining of the edges of the streaks. Also, staining in the center of the macula is present due to extension of the Bruch membrane crack. When compared to early fluorescein angiography, no active leakage is present.

Progression of angioid streaks. Large subretinal ...
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Media file 4: Progression of angioid streaks. Large subretinal hemorrhage.
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Progression of angioid streaks. Large subretinal ...

Progression of angioid streaks. Large subretinal hemorrhage.

Same eye as in Media file 4, 11 months later. Par...
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Media file 5: Same eye as in Media file 4, 11 months later. Partial resolution of subretinal blood. Notice the old subretinal hemorrhage under the fovea and color change to white-yellow.
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Same eye as in Media file 4, 11 months later. Par...

Same eye as in Media file 4, 11 months later. Partial resolution of subretinal blood. Notice the old subretinal hemorrhage under the fovea and color change to white-yellow.

Late complication of choroidal neovascularization...
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Media file 6: Late complication of choroidal neovascularization in angioid streaks. Same eye as in Media file 5, 5 years later. Notice the extensive scarring and subretinal exudates and dehemoglobinized blood.
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Late complication of choroidal neovascularization...

Late complication of choroidal neovascularization in angioid streaks. Same eye as in Media file 5, 5 years later. Notice the extensive scarring and subretinal exudates and dehemoglobinized blood.

Right eye, midphase arteriovenous, showing chorio...
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Media file 7: Right eye, midphase arteriovenous, showing choriocapillaris atrophic changes. This 45-year-old patient underwent 3 injections of Avastin and one session of half-time photodynamic therapy.
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Right eye, midphase arteriovenous, showing chorio...

Right eye, midphase arteriovenous, showing choriocapillaris atrophic changes. This 45-year-old patient underwent 3 injections of Avastin and one session of half-time photodynamic therapy.

Same patient as in Media file 7, a few months bef...
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Media file 8: Same patient as in Media file 7, a few months before the Avastin injection and half-time photodynamic therapy.
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Same patient as in Media file 7, a few months bef...

Same patient as in Media file 7, a few months before the Avastin injection and half-time photodynamic therapy.

More on Angioid Streaks

Overview: Angioid Streaks
Differential Diagnoses & Workup: Angioid Streaks
Treatment & Medication: Angioid Streaks
Follow-up: Angioid Streaks
Multimedia: Angioid Streaks
References
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References

  1. Doyne RW. Choroidal and retinal changes. The result of blows on the eyes. Trans Ophthal. 1889;9:128.

  2. Knapp H. On the formation of dark angioid streaks as an unusual metamorphosis of retinal hemorrhage. Arch Ophthalmol. 1892;21:289-292.

  3. Klien BA. Angioid Streaks: A clinical and histopathologic study. American Journal of Ophthalmology. 1947;30:955-68.

  4. Clarkson JG, Altman RD. Angioid streaks. Surv Ophthalmol. Mar-Apr 1982;26(5):235-46. [Medline].

  5. Karacorlu M, Karacorlu S, Ozdemir H, et al. Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. Am J Ophthalmol. Sep 2002;134(3):360-6. [Medline].

  6. Eckstein M, Wells JA, Aylward B, Gregor Z, et al. Surgical removal of non-age-related subfoveal choroidal neovascular membranes. Eye. 1998;12 (Pt 5):775-80. [Medline].

  7. Adelung JC. Zur Geneseder angioid streaks (Knapp). Klin Monatsbl Augenheilkd. 1951;119:241.

  8. Aveline B, Hasan T, Redmond RW. Photophysical and photosensitizing properties of benzoporphyrin derivative monoacid ring A (BPD-MA). Photochem Photobiol. Mar 1994;59(3):328-35. [Medline].

  9. Bock J. Zur Klinik und Anatomic der gefaessehnlichen Streifen in Augenhintergrund. Z Augenheilkd. 1938;95:1-50.

  10. Eretto P, Krohel GB, Shihab ZM, et al. Optic neuropathy in Paget's disease. Am J Ophthalmol. Apr 1984;97(4):505-10. [Medline].

  11. Francois J, De Laey JJ, Cambie E, et al. Neovascularization after argon laser photocoagulation of macular lesions. Am J Ophthalmol. Feb 1975;79(2):206-10. [Medline].

  12. Gass J, Donald M. Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment. Vol. 1. 4th ed. CV Mosby: 1997:120.

  13. Gelisken O, Hendrikse F, Deutman AF. A long-term follow-up study of laser coagulation of neovascular membranes in angioid streaks. Am J Ophthalmol. Mar 15 1988;105(3):299-303. [Medline].

  14. Guyer DR, Gragoudas ES, D'Amico DJ. Chapter 66: Angioid Streaks. In: Principles and Practice of Ophthalmology. Vol. 2. 1993:852-60.

  15. Hagedoorn A. Angioid streaks. Arch Ophthalmol. 1939;21:746-74.

  16. Heimann H, Gelisken F, Wachtlin J, et al. Photodynamic therapy with verteporfin for choroidal neovascularization associated with angioid streaks. Graefes Arch Clin Exp Ophthalmol. Nov 2005;243(11):1115-23. [Medline].

  17. Ladas ID, Georgalas I, Rouvas AA, et al. Photodynamic therapy with verteporfin of choroidal neovascularization in angioid streaks: conventional versus early retreatment. Eur J Ophthalmol. Jan-Feb 2005;15(1):69-73. [Medline].

  18. Lafaut BA, Leys AM, Scassellati-Sforzolini B, et al. Comparison of fluorescein and indocyanine green angiography in angioid streaks. Graefes Arch Clin Exp Ophthalmol. May 1998;236(5):346-53. [Medline].

  19. Macular Photocoagulation Study. Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Macular Photocoagulation Study Group. Arch Ophthalmol. Jun 1990;108(6):825-31. [Medline].

  20. Macular Photocoagulation Study Group. Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of ocular histoplasmosis. Macular Photocoagulation Study Group. Arch Ophthalmol. Mar 1989;107(3):344-52. [Medline].

  21. Meislik J, Neldner K, Reeve EB, et al. Laser treatment in maculopathy of pseudoxanthoma elasticum. Can J Ophthalmol. Jul 1978;13(3):210-12. [Medline].

  22. Miller H, Miller B, Ryan SJ. Correlation of choroidal subretinal neovascularization with fluorescein angiography. Am J Ophthalmol. Mar 15 1985;99(3):263-71. [Medline].

  23. Pece A, Avanza P, Introini U, et al. Indocyanine green angiography in angioid streaks. Acta Ophthalmol Scand. Jun 1997;75(3):261-5. [Medline].

  24. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol. Oct 1999;117(10):1329-45. [Medline].

  25. Pierro L, Brancato R, Minicucci M, et al. Echographic diagnosis of Drusen of the optic nerve head in patients with angioid streaks. Ophthalmologica. 1994;208(5):239-42. [Medline].

  26. Piro PA, Scheraga D, Fine S. Angioid Streaks: Natural history and visual prognosis. In: Management of Retinal Vascular and Macular Disorders. Williams and Wilkins; 1983:136-9.

  27. Reinke MH, Canakis C, Husain D, et al. Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey. Ophthalmology. Oct 1999;106(10):1915-23. [Medline].

  28. Schmidt-Erfurth U, Hasan T, Gragoudas E, et al. Vascular targeting in photodynamic occlusion of subretinal vessels. Ophthalmology. Dec 1994;101(12):1953-61. [Medline].

  29. Scott LJ, Goa KL. Verteporfin. Drugs Aging. Feb 2000;16(2):139-46; discussion 147-8. [Medline].

  30. Shields JA, Federman JL, Tomer TL, Annesley WH Jr. Angioid streaks. I. Ophthalmoscopic variations and diagnostic problems. Br J Ophthalmol. May 1975;59(5):257-66. [Medline].

  31. Sickenberg M, Schmidt-Erfurth U, Miller JW, et al. A preliminary study of photodynamic therapy using verteporfin for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes. Arch Ophthalmol. Mar 2000;118(3):327-36. [Medline].

  32. Singerman LJ, Hatem G. Laser treatment of choroidal neovascular membranes in angioid streaks. Retina. 1981;1(2):75-83. [Medline].

  33. Walker ER, Frederickson RG, Mayes MD. The mineralization of elastic fibers and alterations of extracellular matrix in pseudoxanthoma elasticum. Ultrastructure, immunocytochemistry, and X-ray analysis. Arch Dermatol. Jan 1989;125(1):70-6. [Medline].

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Further Reading

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Keywords

angioid streaks, retinal hemorrhage, Bruch membrane, Bruch's membrane, choroidal neovascularization, CNV, choroidal neovascular membrane, CNVM

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Contributor Information and Disclosures

Author

Mohammad Abusamak, MD, Chief Retina Division, Assistant Professor, Division of Ophthalmology, Jordan University Hospital
Mohammad Abusamak, MD is a member of the following medical societies: American Academy of Ophthalmology and American Society of Retina Specialists
Disclosure: Nothing to disclose.

Medical Editor

Russell P Jayne, MD, Consulting Vitreoretinal Surgeon, The Retina Center at Las Vegas
Russell P Jayne, MD is a member of the following medical societies: American Medical Association, American Society of Cataract and Refractive Surgery, and American Society of Retina Specialists
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Steve Charles, MD, Director of Charles Retina Institute; Clinical Professor, Department of Ophthalmology, University of Tennessee College of Medicine
Steve Charles, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Retina Specialists, Club Jules Gonin, Macula Society, and Retina Society
Disclosure: Alcon Laboratories Consulting fee Consulting; OptiMedica Ownership interest Consulting

CME Editor

Lance L Brown, OD, MD, Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri
Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD, Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences
Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology
Disclosure: Nothing to disclose.

 
 
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