Conjunctival Papilloma Medication

  • Author: Hon-Vu Q Duong; Chief Editor: Hampton Roy Sr, MD   more...
 
Updated: Feb 11, 2010
 

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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H2-receptor antagonists

Class Summary

Indicated for recalcitrant conjunctival papilloma.

Cimetidine (Tagamet)

 

May enhance immune system by inhibiting suppressor T-cell function and augmenting delayed-type hypersensitivity responses.

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Immune modulators

Class Summary

May induce delayed hypersensitivity reaction causing the tumor to regress. Exact mechanism is unknown.

Dinitrochlorobenzene

 

Contact sensitizers that induce allergic contact dermatitis, causing a localized inflammation and immune response.

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Interferon

Class Summary

Naturally produced proteins with antiviral, antitumor, and immunomodulatory actions.

Interferon alpha-2b (Intron A)

 

Protein product manufactured by recombinant DNA technology. Mechanism of antitumor activity is not clearly understood; however, direct antiproliferative effects against malignant cells and modulation of host immune response may play important roles.

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Antineoplastic agents

Class Summary

Inhibit cell growth and proliferation.

Mitomycin-C (Mutamycin)

 

Acts like alkylating agent, inducing DNA cross-linking, primarily with guanine and cytosine base pairs, which, in turn, inhibits DNA synthesis.

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Contributor Information and Disclosures
Author

Hon-Vu Q Duong  MD, Clinical Instructor of Ophthalmology and Ophthalmic Pathology, Westfield Eye Center

Hon-Vu Q Duong is a member of the following medical societies: American Academy of Ophthalmology

Disclosure: Nothing to disclose.

Coauthor(s)

Robert Copeland, MD  Chair, Associate Professor, Department of Ophthalmology, Howard University College of Medicine

Robert Copeland, MD is a member of the following medical societies: American Academy of Ophthalmology

Disclosure: Nothing to disclose.

Specialty Editor Board

Stephen D Plager, MD, FACS  Chief, Department of Ophthalmology, Dominican Hospital; Assistant Clinical Professor, Department of Ophthalmology, Stanford University Hospital

Stephen D Plager, MD, FACS is a member of the following medical societies: American College of Surgeons, American Medical Association, American Society of Cataract and Refractive Surgery, and California Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Christopher J Rapuano, MD  Professor, Department of Ophthalmology, Jefferson Medical College of Thomas Jefferson University; Director of the Cornea Service, Co-Director of Refractive Surgery Department, Wills Eye Institute

Christopher J Rapuano, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Cataract and Refractive Surgery, Contact Lens Association of Ophthalmologists, Cornea Society, Eye Bank Association of America, International Society of Refractive Surgery, and Pan-American Association of Ophthalmology

Disclosure: Allergan Honoraria Speaking and teaching; Allergan Consulting fee Consulting; Alcon Honoraria Speaking and teaching; Inspire Honoraria Speaking and teaching; RPS Ownership interest Other; Vistakon Honoraria Speaking and teaching; EyeGate Pharma Consulting; Inspire Consulting fee Consulting; Bausch & Lomb Honoraria Speaking and teaching; Bausch & Lomb Consulting fee Consulting

Lance L Brown, OD, MD  Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri

Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD  Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

References
  1. Peck N, Lucarelli MJ, Yao M, et al. Human papillomavirus 6a lesions of the lower eyelid and genitalia. Ophthal Plast Reconstr Surg. Jul-Aug 2006;22(4):311-3. [Medline].

  2. Sjo NC, Buchwald CV, Cassonnet P, et al. Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma. Types and frequencies in a large series. Br J Ophthalmol. Dec 13 2006;[Medline].

  3. Minchiotti S, Masucci L, Serapiao Dos Santos M, Perrella E, Graffeo R, Lambiase A. Conjunctival papilloma and human papillomavirus: identification of HPV types by PCR. Eur J Ophthalmol. May-Jun 2006;16(3):473-7. [Medline].

  4. Egbert JE, Kersten RC. Female genital tract papillomavirus in conjunctival papillomas of infancy. Am J Ophthalmol. Apr 1997;123(4):551-2. [Medline].

  5. Lauer SA. Recurrent conjunctival papilloma causing nasolacrimal duct obstruction. Am J Ophthalmol. Nov 15 1990;110(5):580-1. [Medline].

  6. Migliori ME, Putterman AM. Recurrent conjunctival papilloma causing nasolacrimal duct obstruction. Am J Ophthalmol. Jul 15 1990;110(1):17-22. [Medline].

  7. Petrelli R, Cotlier E, Robins S, Stoessel K. Dinitrochlorobenzene immunotherapy of recurrent squamous papilloma of the conjunctiva. Ophthalmology. Dec 1981;88(12):1221-5. [Medline].

  8. Lass JH, Foster CS, Grove AS, et al. Interferon-alpha therapy of recurrent conjunctival papillomas. Am J Ophthalmol. Mar 15 1987;103(3 Pt 1):294-301. [Medline].

  9. Muralidhar R, Sudan R, Bajaj MS, Sharma V. Topical interferon alpha-2b as an adjunctive therapy in recurrent conjunctival papilloma. Int Ophthalmol. Feb 2009;29(1):61-2. [Medline].

  10. de Keizer RJ, de Wolff-Rouendaal D. Topical alpha-interferon in recurrent conjunctival papilloma. Acta Ophthalmol Scand. Apr 2003;81(2):193-6. [Medline].

  11. Falco LA, Gruosso PJ, Skolnick K, Bejar L. Topical interferon alpha 2 beta therapy in the management of conjunctival papilloma. Optometry. Apr 2007;78(4):162-6. [Medline].

  12. Hawkins AS, Yu J, Hamming NA, Rubenstein JB. Treatment of recurrent conjunctival papillomatosis with mitomycin C. Am J Ophthalmol. Nov 1999;128(5):638-40. [Medline].

  13. Shields CL, Lally MR, Singh AD, et al. Oral cimetidine (Tagamet) for recalcitrant, diffuse conjunctival papillomatosis. Am J Ophthalmol. Sep 1999;128(3):362-4. [Medline].

  14. Chang SW, Huang ZL. Oral cimetidine adjuvant therapy for recalcitrant, diffuse conjunctival papillomatosis. Cornea. Jul 2006;25(6):687-90. [Medline].

  15. Schachat A, Iliff WJ, Kashima HK. Carbon dioxide laser therapy of recurrent squamous papilloma of the conjunctiva. Ophthalmic Surg. Nov 1982;13(11):916-8. [Medline].

  16. Jackson WB, Beraja R, Codere F. Laser therapy of conjunctival papillomas. Can J Ophthalmol. Feb 1987;22(1):45-7. [Medline].

  17. Bailey RN, Guethlein ME. Diagnosis and management of conjunctival papillomas. J Am Optom Assoc. May 1990;61(5):405-12. [Medline].

  18. Bosniak SL, Novick NL, Sachs ME. Treatment of recurrent squamous papillomata of the conjunctiva by carbon dioxide laser vaporization. Ophthalmology. Aug 1986;93(8):1078-82. [Medline].

  19. Buggage RR, Smith JA, Shen D, Chan CC. Conjunctival papillomas caused by human papillomavirus type 33. Arch Ophthalmol. Feb 2002;120(2):202-4. [Medline].

  20. Campbell RJ. Tumors of the eyelids, conjunctiva, and cornea. In: Garner A, Klintworth GK, eds. Pathobiology of Ocular Disease - A Dynamic Approach. Marcel Dekker Inc; 1994:1367-8(chap 46).

  21. Chang T, Chapman B, Heathcote JG. Inverted mucoepidermoid papilloma of the conjunctiva. Can J Ophthalmol. Jun 1993;28(4):184-6. [Medline].

  22. Chiemchaisri Y, Dongosintr N, Wasi C, et al. The regression of recurrent conjunctival papillomas by lymphoblastoid interferon treatment. J Med Assoc Thai. Jul 1990;73(7):406-13. [Medline].

  23. Eagle RC. Conjunctiva. In: Eye Pathology - An Atlas and Basic Text. Philadelphia, Pa: WB Saunders Co; 1999:47-8, 59, 61-2(chap 4).

  24. Easty DL, Williams C. Viral and rickettsial disease. In: Garner A, Klintworth GK, eds. Pathobiology of Ocular Disease - A Dynamic Approach. Marcel Dekker Inc; 1994:247(chap 7).

  25. Harkey ME, Metz HS. Cryotherapy of conjunctival papillomata. Am J Ophthalmol. Nov 1968;66(5):872-4. [Medline].

  26. Hsu HC, Lin HF. Eyelid tumors in children: a clinicopathologic study of a 10-year review in southern Taiwan. Ophthalmologica. Jul-Aug 2004;218(4):274-7. [Medline].

  27. Jakobiec FA, Harrison W, Aronian D. Inverted mucoepidermoid papillomas of the epibulbar conjunctiva. Ophthalmology. Mar 1987;94(3):283-7. [Medline].

  28. Khalil MK, Pierson RB, Mihalovits H, et al. Intraepithelial neoplasia of the bulbar conjunctiva clinically presenting as diffuse papillomatosis. Can J Ophthalmol. Oct 1993;28(6):287-90. [Medline].

  29. Kremer I, Sandbank J, Weinberger D, et al. Pigmented epithelial tumours of the conjunctiva. Br J Ophthalmol. May 1992;76(5):294-6. [Medline].

  30. Lass JH, Grove AS, Papale JJ, et al. Detection of human papillomavirus DNA sequences in conjunctival papilloma. Am J Ophthalmol. Nov 1983;96(5):670-4. [Medline].

  31. Lass JH, Jenson AB, Papale JJ, Albert DM. Papillomavirus in human conjunctival papillomas. Am J Ophthalmol. Mar 1983;95(3):364-8. [Medline].

  32. Mantyjarvi M, Syrjanen S, Kaipiainen S, et al. Detection of human papillomavirus type 11 DNA in a conjunctival squamous cell papilloma by in situ hybridization with biotinylated probes. Acta Ophthalmol (Copenh). Aug 1989;67(4):425-9. [Medline].

  33. Margo CE, Mack WP. Therapeutic decisions involving disparate clinical outcomes: patient preference survey for treatment of central retinal artery occlusion. Ophthalmology. Apr 1996;103(4):691-6. [Medline].

  34. McDonnell JM, Lass JH. Human papillomavirus diseases. In: Pepose JS, et al, eds. Ocular Infection and Immunity. New York: Mosby; 1996:857-68(chap 67).

  35. McDonnell JM, McDonnell PJ, Mounts P, et al. Demonstration of papillomavirus capsid antigen in human conjunctival neoplasia. Arch Ophthalmol. Dec 1986;104(12):1801-5. [Medline].

  36. McDonnell PJ, McDonnell JM, Kessis T, et al. Detection of human papillomavirus type 6/11 DNA in conjunctival papillomas by in situ hybridization with radioactive probes. Hum Pathol. Nov 1987;18(11):1115-9. [Medline].

  37. McLean IW, et al. Tumors of the conjunctiva (Chapter 3). In: Tumors of the Eye and Ocular Adnexa. Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology;1994:49-52.

  38. Mincione GP, Taddei GL, Wolovsky M, et al. Detection of human papillomavirus (HPV) DNA type 6/11 in a conjunctival papilloma by in situ hybridization with biotinylated probes. Pathologica. Jul-Aug 1992;84(1092):483-8. [Medline].

  39. Miyagawa M, Hayasaka S, Nagaoka S, Mihara M. Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma. Ophthalmologica. 1994;208(1):46-8. [Medline].

  40. Morsman CD. Spontaneous regression of a conjunctival intraepithelial neoplastic tumor. Arch Ophthalmol. Oct 1989;107(10):1490-1. [Medline].

  41. Omohundro JM, Elliott JH. Cryotherapy of conjunctival papilloma. Arch Ophthalmol. Nov 1970;84(5):609-10. [Medline].

  42. Pfister H, Fuchs PG, Volcker HE. Human papillomavirus DNA in conjunctival papilloma. Graefes Arch Clin Exp Ophthalmol. 1985;223(3):164-7. [Medline].

  43. Rumelt S, Pe'er J, Rubin PA. The clinicopathological spectrum of benign peripunctal tumours. Graefes Arch Clin Exp Ophthalmol. Feb 2005;243(2):113-9. [Medline].

  44. Saegusa M, Takano Y, Hashimura M, et al. HPV type 16 in conjunctival and junctional papilloma, dysplasia, and squamous cell carcinoma. J Clin Pathol. Dec 1995;48(12):1106-10. [Medline].

  45. Schechter BA, Rand WJ, Velazquez GE, et al. Treatment of conjunctival papillomata with topical interferon Alfa-2b. Am J Ophthalmol. Aug 2002;134(2):268-70. [Medline].

  46. Slade CS, Katz NN, Whitmore PV, Bardenstein DS. Conjunctival and canalicular papillomas and ichthyosis vulgaris. Ann Ophthalmol. Jul 1988;20(7):251-5. [Medline].

  47. Spencer WH. Neoplasms and related conditions (Chapter 2). In: Ophthalmic Pathology - An Atlas and Textbook. Vol. 1. Philadelphia, Pa: WB Saunders Co;1996:106-11.

  48. Wells GB, Lasner TM, Yousem DM, Zager EL. Lhermitte-Duclos disease and Cowden's syndrome in an adolescent patient. Case report. J Neurosurg. Jul 1994;81(1):133-6. [Medline].

  49. Wilson FM, Ostler HB. Conjunctival papillomas in siblings. Am J Ophthalmol. Jan 1974;77(1):103-7. [Medline].

  50. Yanoff M, Fine BS. Conjunctiva - pseudocancerous lesions. In: Ocular Pathology. 4th ed. New York: Mosby-Wolfe; 1996:220-1(chap 7).

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