Granular Dystrophy Medication
- Author: Natalie Afshari, MD, MA, FACS; Chief Editor: Hampton Roy Sr, MD more...
Medication Summary
Medical therapy for recurrent corneal erosions includes hypertonic saline, which is believed to increase adherence of epithelium to the underlying stroma. Lubrication, especially at bedtime, also may help prevent further corneal erosions.
Hypertonic saline drops
Class Summary
This agent dehydrates the epithelium, allowing it to better adhere to underlying stroma.
Sodium chloride hypertonic, ophthalmic (Adsorbonac, Afrin Saline Mist, Muro 128)
Used for temporary relief of corneal edema.
Lubricating agents
Class Summary
These agents can moisten ocular surface and decrease the frequency of recurrent erosions.
Artificial tears (Celluvisc, Murine, Refresh, GenTeal, Refresh PM, Lacri-Lube)
Contains equivalent of 0.9% NaCl and are used to maintain ocular tonicity. Acts to stabilize and thicken precorneal tear film and prolong tear film breakup time, which occurs with dry eye states.
Grunauer-Kloevekorn C, Brautigam S, Wolter-Roessler M. Molecular genetic analysis of the BIGH3 gene in lattice type I (Biber-Haab-Dimmer) and granular type II (Avellino) corneal dystrophy: is indirect mutation analysis for hot spots recommended?. Klin Monatsbl Augenheilkd. Dec 2005;222(12):1017-23. [Medline].
Mori H, Miura M, Iwasaki T, et al. Three-dimensional optical coherence tomography-guided phototherapeutic keratectomy for granular corneal dystrophy. Cornea. Sep 2009;28(8):944-7. [Medline].
Dalton K, Schneider S, Sorbara L, Jones L. Confocal microscopy and optical coherence tomography imaging of hereditary granular dystrophy. Cont Lens Anterior Eye. Nov 27 2009;[Medline].
Das S, Langenbucher A, Seitz B. Excimer laser phototherapeutic keratectomy for granular and lattice corneal dystrophy: a comparative study. J Refract Surg. Nov-Dec 2005;21(6):727-31. [Medline].
Albert D, Jakobiec F. Principles and Practice of Ophthalmology. Vol 1. 1994:26-49.
Klintworth GK. Advances in the molecular genetics of corneal dystrophies. Am J Ophthalmol. Dec 1999;128(6):747-54. [Medline].
Krachmer J. Cornea. Vol 2. 1996.
Yamamoto S, Okada M, Tsujikawa M, et al. The spectrum of beta ig-h3 gene mutations in Japanese patients with corneal dystrophy. Cornea. May 2000;19(3 Suppl):S21-3. [Medline].

