eMedicine Specialties > Ophthalmology > Cornea
Dystrophy, Macular: Differential Diagnoses & Workup
Updated: Mar 16, 2006
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Differential Diagnoses
Dystrophy, Crystalline
Dystrophy, Granular
Dystrophy, Lattice
Other Problems to Be Considered
Corneal opacities
Workup
Procedures
- A corneal biopsy sample (which would never be clinically indicated) would reveal deposits of glycosaminoglycans, which stain with Alcian blue and colloidal iron.
- Light microscopy reveals glycosaminoglycan deposits within stromal keratocytes.
Histologic Findings
Deposits in macular dystrophy are composed of glycosaminoglycans, which stain with Alcian blue and colloidal iron. Light microscopy demonstrates glycosaminoglycan deposits within stromal keratocytes. Two types of macular dystrophy exist based on the absence or presence of keratan sulfate within the corneal stroma. Type I macular dystrophy has an absence of keratan sulfate, whereas in type II, keratan sulfate is present.
More on Dystrophy, Macular |
| Overview: Dystrophy, Macular |
Differential Diagnoses & Workup: Dystrophy, Macular |
| Treatment & Medication: Dystrophy, Macular |
| Follow-up: Dystrophy, Macular |
| Multimedia: Dystrophy, Macular |
| References |
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References
Al-Swailem SA, Al-Rajhi AA, Wagoner MD. Penetrating keratoplasty for macular corneal dystrophy. Ophthalmology. Feb 2005;112(2):220-4. [Medline].
Albert D, Jakobiec F. Principles and Practice of Ophthalmology. Vol 1. 1996:26-49.
Edward DP, Yue BY, Sugar J, et al. Heterogeneity in macular corneal dystrophy. Arch Ophthalmol. Nov 1988;106(11):1579-83. [Medline].
Hafner A, Langenbucher A, Seitz B. Long-term results of phototherapeutic keratectomy with 193-nm excimer laser for macular corneal dystrophy. Am J Ophthalmol. Sep 2005;140(3):392-6. [Medline].
Klintworth GK, Meyer R, Dennis R, et al. Macular corneal dystrophy. Lack of keratan sulfate in serum and cornea. Ophthalmic Paediatr Genet. Dec 1986;7(3):139-43. [Medline].
Krachmer J. Cornea. Vol 2. 1996.
Wirtitsch MG, Ergun E, Hermann B. Ultrahigh resolution optical coherence tomography in macular dystrophy. Am J Ophthalmol. Dec 2005;140(6):976-983. [Medline].
Further Reading
Keywords
corneal dystrophy, corneal stroma, anterior corneal dystrophy, stromal corneal dystrophy, posterior corneal dystrophy, corneal dystrophies
Differential Diagnoses & Workup: Dystrophy, Macular