eMedicine Specialties > Ophthalmology > Cornea
Dystrophy, Macular: Differential Diagnoses & Workup
Updated: Jan 26, 2010
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Differential Diagnoses
Dystrophy, Crystalline
Dystrophy, Granular
Dystrophy, Lattice
Other Problems to Be Considered
Corneal opacities
Workup
Procedures
- A corneal biopsy sample, which is not clinically indicated, reveals deposits of glycosaminoglycans, which stain with Alcian blue and colloidal iron.
- Light microscopy reveals glycosaminoglycan deposits within stromal keratocytes.
Histologic Findings
- Deposits in macular dystrophy are composed of glycosaminoglycans, which stain with Alcian blue and colloidal iron.
- Light microscopy demonstrates glycosaminoglycan deposits within stromal keratocytes.
- Two types of macular dystrophy are noted based on the absence or presence of keratan sulfate within the corneal stroma. Type I macular dystrophy has an absence of keratan sulfate, whereas in type II, keratan sulfate is present.
More on Dystrophy, Macular |
| Overview: Dystrophy, Macular |
Differential Diagnoses & Workup: Dystrophy, Macular |
| Treatment & Medication: Dystrophy, Macular |
| Follow-up: Dystrophy, Macular |
| Multimedia: Dystrophy, Macular |
| References |
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References
Kannabiran C. Genetics of corneal endothelial dystrophies. J Genet. Dec 2009;88(4):487-94. [Medline].
Quantock AJ, Young RD, Akama TO. Structural and biochemical aspects of keratan sulphate in the cornea. Cell Mol Life Sci. Dec 27 2009;[Medline].
Al-Swailem SA, Al-Rajhi AA, Wagoner MD. Penetrating keratoplasty for macular corneal dystrophy. Ophthalmology. Feb 2005;112(2):220-4. [Medline].
Albert D, Jakobiec F. Principles and Practice of Ophthalmology. Vol 1. 1996:26-49.
Edward DP, Yue BY, Sugar J, et al. Heterogeneity in macular corneal dystrophy. Arch Ophthalmol. Nov 1988;106(11):1579-83. [Medline].
Hafner A, Langenbucher A, Seitz B. Long-term results of phototherapeutic keratectomy with 193-nm excimer laser for macular corneal dystrophy. Am J Ophthalmol. Sep 2005;140(3):392-6. [Medline].
Klintworth GK, Meyer R, Dennis R, et al. Macular corneal dystrophy. Lack of keratan sulfate in serum and cornea. Ophthalmic Paediatr Genet. Dec 1986;7(3):139-43. [Medline].
Krachmer J. Cornea. Vol 2. 1996.
Wirtitsch MG, Ergun E, Hermann B. Ultrahigh resolution optical coherence tomography in macular dystrophy. Am J Ophthalmol. Dec 2005;140(6):976-983. [Medline].
Further Reading
Keywords
corneal dystrophy, corneal stroma, anterior corneal dystrophy, stromal corneal dystrophy, posterior corneal dystrophy, corneal dystrophies
Differential Diagnoses & Workup: Dystrophy, Macular