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Dystrophy, Map-dot-fingerprint: Differential Diagnoses & Workup

Author: David Verdier, MD, Clinical Professor, Department of Surgery, Division of Ophthalmology, Michigan State University College of Human Medicine
Contributor Information and Disclosures

Updated: May 26, 2009

Differential Diagnoses

Corneal Abrasion
Dystrophy, Fuchs Endothelial
Herpes Simplex
Herpes Zoster

Other Problems to Be Considered

Corneal trauma
Diabetes mellitus (can be thickened and redundant basement membrane)
Corneal suture lines (junction of a healing corneal epithelial defect)
Radial keratotomy (can have corneal epithelial opacities clinically indistinguishable from map-dot-fingerprint dystrophy)

Workup

Histologic Findings

The corneal maps in map-dot-fingerprint dystrophy histologically represent areas of multilaminar basement membrane, which extend into the epithelium. The corneal dots in map-dot-fingerprint dystrophy are intraepithelial microcysts that contain nuclear, cytoplasmic, and lipid debris. The corneal fingerprints in map-dot-fingerprint dystrophy are curvilinear clusters of reduplicated and thickened basement membrane and fibrillogranular material. 

Blebs, a less common manifestation of map-dot-fingerprint dystrophy, are localized areas of fibrillogranular material or thickened basement membrane.

More on Dystrophy, Map-dot-fingerprint

Overview: Dystrophy, Map-dot-fingerprint
Differential Diagnoses & Workup: Dystrophy, Map-dot-fingerprint
Treatment & Medication: Dystrophy, Map-dot-fingerprint
Follow-up: Dystrophy, Map-dot-fingerprint
Multimedia: Dystrophy, Map-dot-fingerprint
References

References

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Further Reading

Keywords

map-dot-fingerprint dystrophy, corneal map-dot-fingerprint dystrophy, Cogan’s dystrophy, Cogan's microcystic dystrophy, anterior basement membrane dystrophy, epithelial basement membrane dystrophy, corneal dystrophy, corneal dystrophies, corneal degeneration, corneal erosion

Contributor Information and Disclosures

Author

David Verdier, MD, Clinical Professor, Department of Surgery, Division of Ophthalmology, Michigan State University College of Human Medicine
David Verdier, MD is a member of the following medical societies: American Academy of Ophthalmology, American Medical Association, Cornea Society, Eye Bank Association of America, Michigan Society of Eye Physicians & Surgeons, and Michigan State Medical Society
Disclosure: Nothing to disclose.

Medical Editor

Fernando H Murillo-Lopez, MD, Senior Surgeon, Unidad Privada de Oftalmologia CEMES
Fernando H Murillo-Lopez, MD is a member of the following medical societies: American Academy of Ophthalmology
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Christopher J Rapuano, MD, Professor, Department of Ophthalmology, Jefferson Medical College of Thomas Jefferson University; Co-Chairman of the Cornea Service, Co-Chairman of Refractive Surgery Department, Wills Eye Institute
Christopher J Rapuano, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Cataract and Refractive Surgery, Contact Lens Association of Ophthalmologists, Cornea Society, Eye Bank Association of America, International Society of Refractive Surgery, and Pan-American Association of Ophthalmology
Disclosure: Allergan Honoraria Speaking and teaching; Allergan Consulting fee Consulting; Alcon Honoraria Speaking and teaching; Inspire Honoraria Speaking and teaching; RPS Ownership interest Other; Vistakon Honoraria Speaking and teaching

CME Editor

Lance L Brown, OD, MD, Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri
Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD, Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences
Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology
Disclosure: Nothing to disclose.

 
 
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