eMedicine Specialties > Ophthalmology > Cornea
Neovascularization, Corneal, CL-related: Differential Diagnoses & Workup
Updated: Apr 10, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Differential Diagnoses
| Contact Lens Complications | Keratitis, Interstitial |
| Herpes Simplex | Onchocerciasis |
| Herpes Zoster | Squamous Cell Carcinoma, Conjunctival |
| Keratitis, Herpes Simplex | Tuberculosis |
Other Problems to Be Considered
Trauma and other diseases that cause interstitial keratitis (eg, ocular herpes simplex and zoster virus infections, measles, tuberculosis, syphilitic keratitis, onchocerciasis)
Workup
Laboratory Studies
- For systemic medical reasons, it is important to obtain a thorough case history of CL wear and to exclude other potential causes of corneal NV, especially if NV is seen deep in the corneal stroma. Pay attention to causes of interstitial keratitis such as herpes keratitis, tuberculosis, measles, and syphilis.
- Herpes cultures if herpes is suspected and the diagnosis cannot be made on clinical examination
- Tuberculosis (TB) skin test if TB is suspected
- Rapid plasma reagin (RPR) and microhemagglutination-Treponema pallidum (MHA-TP) if syphilis is suspected
More on Neovascularization, Corneal, CL-related |
| Overview: Neovascularization, Corneal, CL-related |
Differential Diagnoses & Workup: Neovascularization, Corneal, CL-related |
| Treatment & Medication: Neovascularization, Corneal, CL-related |
| Follow-up: Neovascularization, Corneal, CL-related |
| References |
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References
Dixon JM. Corneal vascularization due to corneal contact lenses: the clinical picture. Trans Am Ophthalmol Soc. 1967;65:333-40. [Medline].
Dixon JM, Lawaczec E. Corneal vascularization due to contact lenses. Arch Ophthalmol. 1963;69:106-9.
Chan WK, Weissman BA. Corneal pannus associated with contact lens wear. Am J Ophthalmol. May 1996;121(5):540-6. [Medline].
Cogan DG. Vascularization of the cornea. Its experimental induction by small lesions and a new theory of its pathogenesis. Arch Ophthalmol. 1949;41:406-416.
Cogan DG. Corneal vascularization. Investigative Ophthalmology and Vis. 1962;(1): 2:253-61.
Ashton N, Cook C. Mechanisms of corneal neovascularization. Brit J Ophthal. 1953;37:193-209.
Madigan MC, Penfold PL, Holden BA, Billson FA. Ultrastructural features of contact lens-induced deep corneal neovascularization and associated stromal leukocytes. Cornea. Apr 1990;9(2):144-51. [Medline].
Groden LR, Cassel GH, Laibson PR. The effect of corneal trephination on neovascularization. Ophthalmic Surg. Nov 1983;14(11):954-6. [Medline].
Imre G. The role of increased lactic acid concentration in neovascularizations. Acta Morphol Hung. 1984;32(2):97-103. [Medline].
Fromer CH, Klintworth GK. An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. Am J Pathol. Jun 1975;79(3):537-54. [Medline].
Fromer CH, Klintworth GK. An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. III. Studies related to the vasoproliferative capability of polymorphonuclear leukocytes and lymphocytes. Am J Pathol. Jan 1976;82(1):157-70. [Medline].
Koch AE, Polverini PJ, Leibovich SJ. Induction of neovascularization by activated human monocytes. J Leukoc Biol. Feb 1986;39(2):233-8. [Medline].
Klintworth GK. Corneal Angiogenesis. New York: Springer-Verlag; 1991:1-30.
Forister J, Forister EF, Yeung KK, Chung MY, Ye P, Tsai A, et al. Weissman BA. Prevalence of common ocular complications associated with contact lens wear: The UCLA contact lens complication study. Vis Opt Sci (In preparation).
Donnenfeld ED, Ingraham H, Perry HD, Imundo M, Goldberg LP. Contact lens-related deep stromal intracorneal hemorrhage. Ophthalmology. Dec 1991;98(12):1793-6. [Medline].
Filipec M, Hycl J, Kraus H. [Does vascularization and the graft diameter affect the rejection reaction in corneal transplantation?]. Cesk Oftalmol. Feb 1994;50(1):13-7. [Medline].
Foulks GN, Steffanson E, Hamilton RC. Regression of corneal vascularization during silicone contact lens wear and the relationship to contact lens-induced anterior chamber hypoxia. Cornea. 1987;65:6-60.
Qian CX, Bahar I, Levinger E, Rootman D. Combined use of superficial keratectomy and subconjunctival bevacizumab injection for corneal neovascularization. Cornea. Oct 2008;27(9):1090-2. [Medline].
Benelli U, Bocci G, Danesi R, Lepri A, Bernardini N, Bianchi F. The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization. Exp Eye Res. Aug 1998;67(2):133-42. [Medline].
Crum R, Szabo S, Folkman J. A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment. Science. Dec 20 1985;230(4732):1375-8. [Medline].
Lipman RM, Epstein RJ, Hendricks RL. Suppression of corneal neovascularization with cyclosporine. Arch Ophthalmol. Mar 1992;110(3):405-7. [Medline].
D'Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A. Apr 26 1994;91(9):4082-5. [Medline].
Bian F, Zhang MC, Zhu Y. Inhibitory effect of curcumin on corneal neovascularization in vitro and in vivo. Ophthalmologica. 2008;222(3):178-86. [Medline].
Wong AL, Weissman BA, Mondino BJ. Bilateral corneal neovascularization and opacification associated with unmonitored contact lens wear. Am J Ophthalmol. Nov 2003;136(5):957-8. [Medline].
Maguire MB. Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Opthal. 1974;101:1536-1547.
Sawa M, Awazu K, Takahashi T, et al. Application of femtosecond ultrashort pulse laser to photodynamic therapy mediated by indocyanine green. Br J Ophthalmol. Jun 2004;88(6):826-31. [Medline].
Holzer MP, Solomon KD, Vroman DT, et al. Photodynamic therapy with verteporfin in a rabbit model of corneal neovascularization. Invest Ophthalmol Vis Sci. Jul 2003;44(7):2954-8. [Medline].
Caffery BE, Josephson JE. Corneal vascularization. Optom Clin. 1995;4(3):19-29. [Medline].
Grohe RM, Lebow KA. Vascularized limbal keratitis. Int Contact Lens Clinics. 1989;16:197-209.
Jouseen AM, Druse FE, Volcker HE, et al. Topical application of methotrexate for inhibition of corneal angiogenesis. Graefes Arch Clin Exp Ophthalmol. 1999;238:920-7.
Verbey NL, van Haeringen NJ, de Jong PT. Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of liposygenase and cyclooxygenase. Curr Eye Res. 1998;7:361-8.
Further Reading
Keywords
cornea, contact lens, neovascularization, corneal trauma
Differential Diagnoses & Workup: Neovascularization, Corneal, CL-related