Keratitis Sicca Differential Diagnoses
- Author: Mark Ventocilla, OD, FAAO; Chief Editor: Hampton Roy Sr, MD more...
Diagnostic Considerations
The differential diagnosis for keratitis sicca is large. Conditions to consider are those that include conjunctivitis (allergic, bacterial, giant papillary, viral; atopic keratoconjunctivitis), filamentary keratitis, infectious diseases (chlamydia, herpes simplex and herpes simplex keratitis, herpes zoster), corneal abnormalities (abrasion, erosion, foreign body, mucous plaques), and other keratitis (interstitial) and keratopathies (neurotrophic, pseudophakic bullous).
Differential Diagnoses
- Contact Lens Complications
- Dermatitis, Atopic
- Dermatitis, Contact
- Dystrophy, Map-dot-fingerprint
- Episcleritis
- Familial Dysautonomia
- Ichthyosis
- Ocular Rosacea
- Psoriasis
- Scleritis
Lee HK, Ryu IH, Seo KY, Hong S, Kim HC, Kim EK. Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. Ophthalmology. Feb 2006;113(2):198-205. [Medline].
Foulks GN. The correlation between the tear film lipid layer and dry eye disease. Surv Ophthalmol. Jul-Aug 2007;52(4):369-74. [Medline].
Fujita M, Igarashi T, Kurai T, Sakane M, Yoshino S, Takahashi H. Correlation between dry eye and rheumatoid arthritis activity. Am J Ophthalmol. Nov 2005;140(5):808-13. [Medline].
Geerling G, Tost FH. Surgical occlusion of the lacrimal drainage system. Dev Ophthalmol. 2008;41:213-29. [Medline].
Barber LD, Pflugfelder SC, Tauber J, Foulks GN. Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. Oct 2005;112(10):1790-4. [Medline].
Stonecipher K, Perry HD, Gross RH, Kerney DL. The impact of topical cyclosporine A emulsion 0.05% on the outcomes of patients with keratoconjunctivitis sicca. Curr Med Res Opin. Jul 2005;21(7):1057-63. [Medline].

