eMedicine Specialties > Ophthalmology > Cornea

Central Sterile Corneal Ulceration: Follow-up

Author: Saadia Zohra Farooqui, MBBS, Aga Khan University Medical College, Pakistan
Coauthor(s): C Stephen Foster, MD, FACS, FACR, FAAO, Clinical Professor of Ophthalmology, Harvard Medical School; Consulting Staff, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary; Founder and President, Ocular Immunology and Uveitis Foundation, Massachusetts Eye Research and Surgery Institution; Joseph JK Ma, MD, Staff Physician, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary
Contributor Information and Disclosures

Updated: Nov 6, 2008

Follow-up

Further Outpatient Care

  • Patients must receive close follow-up care until resolution of the corneal ulcer.

Deterrence/Prevention

  • Patients should wear eye protection to prevent injury to the cornea, especially if the cornea is thin.

Complications

  • Complications include corneal scarring, neovascularization, decreased vision, central corneal perforation, and endophthalmitis. Other possible complications include cataract, glaucoma, and blindness.

Prognosis

  • Prognosis depends on the severity of the condition and the patient response to therapy in addition to associated local and systemic factors.

Patient Education

Miscellaneous

Medicolegal Pitfalls

  • Failure to promptly diagnose and provide early treatment to prevent visual loss
  • Failure to first rule out infectious causes

Special Concerns

  • In treating a patient with a corneal ulcer, evaluate for underlying systemic conditions and manage them appropriately.
 


More on Central Sterile Corneal Ulceration

Overview: Central Sterile Corneal Ulceration
Differential Diagnoses & Workup: Central Sterile Corneal Ulceration
Treatment & Medication: Central Sterile Corneal Ulceration
Follow-up: Central Sterile Corneal Ulceration
References

References

  1. Wentworth JS, Paterson CA, Gray RD. Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn. Invest Ophthalmol Vis Sci. Jun 1992;33(7):2174-9. [Medline].

  2. Gabison EE, Mourah S, Steinfels E, et al. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol. Jan 2005;166(1):209-19. [Medline].

  3. Shimmura S, Igarashi R, Yaguchi H, et al. Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers. Am J Ophthalmol. May 2003;135(5):613-9. [Medline].

  4. Tripathi BK, Stepp MA, Gao CY, et al. The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo. Mol Vis. Mar 17 2008;14:542-9. [Medline].

  5. Sigelman S, Friedenwald JS. Mitotic and wound-healing activities of the corneal epithelium; effect of sensory denervation. AMA Arch Ophthalmol. Jul 1954;52(1):46-57. [Medline].

  6. Nakamura M, Chikama T, Nishida T. Synergistic effect with Phe-Gly-Leu-Met-NH2 of the C-terminal of substance P and insulin-like growth factor-1 on epithelial wound healing of rabbit cornea. Br J Pharmacol. May 1999;127(2):489-97. [Medline].

  7. Bonini S, Lambiase A, Rama P, et al. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology. Jul 2000;107(7):1347-51; discussion 1351-2. [Medline].

  8. Dohlman CH, Slansky HH, Laibson PR, et al. Artificial corneal epithelium in acute alkali burns. Ann Ophthalmol. 1969;112.

  9. Kenyon KR, Berman M, Rose J, et al. Prevention of stromal ulceration in the alkali-burned rabbit cornea by glued-on contact lens. Evidence for the role of polymorphonuclear leukocytes in collagen degradation. Invest Ophthalmol Vis Sci. Jun 1979;18(6):570-87. [Medline].

  10. Yoon KC, You IC, Im SK, et al. Application of umbilical cord serum eyedrops for the treatment of neurotrophic keratitis. Ophthalmology. Sep 2007;114(9):1637-42. [Medline].

  11. Alio JL, Abad M, Artola A, et al. Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology. Jul 2007;114(7):1286-1293.e1. [Medline].

  12. Saika S, Miyamoto T, Yamanaka O, et al. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Am J Pathol. May 2005;166(5):1393-403. [Medline].

  13. Sosne G, Qiu P, Christopherson PL, et al. Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway. Exp Eye Res. Apr 2007;84(4):663-9. [Medline].

  14. Saika S, Yamanaka O, Okada Y, et al. Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice. Am J Physiol Cell Physiol. Jul 2007;293(1):C75-86. [Medline].

  15. Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology. 2nd ed. Boston: WB Saunders Co; 2000.

  16. Dua HS, Gomes JA, Singh A. Corneal epithelial wound healing. Br J Ophthalmol. May 1994;78(5):401-8. [Medline].

  17. Geerling G, Joussen AM, Daniels JT, et al. Matrix metalloproteinases in sterile corneal melts. Ann N Y Acad Sci. Jun 30 1999;878:571-4. [Medline].

  18. Gipson IK, Inatomi T. Extracellular matrix and growth factors in corneal wound healing. Curr Opin Ophthalmol. Aug 1995;6(4):3-10. [Medline].

  19. He J, Bazan NG, Bazan HE. Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol. Jan 2006;124(1):70-8. [Medline].

  20. Imanishi J, Kamiyama K, Iguchi I, et al. Growth factors: importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res. Jan 2000;19(1):113-29. [Medline].

  21. Kaufman HE, et al, eds. The Cornea. 2nd ed. Boston: Butterworth-Heinemann; 1998.

  22. Nagano T, Nakamura M, Nakata K, et al. Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy. Invest Ophthalmol Vis Sci. Sep 2003;44(9):3810-5. [Medline].

  23. Watanabe M, Yano W, Kondo S, et al. Up-regulation of urokinase-type plasminogen activator in corneal epithelial cells induced by wounding. Invest Ophthalmol Vis Sci. Aug 2003;44(8):3332-8. [Medline].

  24. Wilson SE, Liu JJ, Mohan RR. Stromal-epithelial interactions in the cornea. Prog Retin Eye Res. May 1999;18(3):293-309. [Medline].

Further Reading

Keywords

central sterile corneal ulceration, neurotrophic ulcer, corneal ulcer, corneal stroma, corneal lesion, keratitis, corneal inflammation, stromal ulceration

Contributor Information and Disclosures

Author

Saadia Zohra Farooqui, MBBS, Aga Khan University Medical College, Pakistan
Disclosure: Nothing to disclose.

Coauthor(s)

C Stephen Foster, MD, FACS, FACR, FAAO, Clinical Professor of Ophthalmology, Harvard Medical School; Consulting Staff, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary; Founder and President, Ocular Immunology and Uveitis Foundation, Massachusetts Eye Research and Surgery Institution
C Stephen Foster, MD, FACS, FACR, FAAO is a member of the following medical societies: Alpha Omega Alpha, American Academy of Ophthalmology, American Association of Immunologists, American College of Rheumatology, American College of Surgeons, American Federation for Clinical Research, American Medical Association, American Society for Microbiology, American Uveitis Society, Association for Research in Vision and Ophthalmology, Massachusetts Medical Society, Royal Society of Medicine, and Sigma Xi
Disclosure: Nothing to disclose.

Joseph JK Ma, MD, Staff Physician, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary
Joseph JK Ma, MD is a member of the following medical societies: American Academy of Ophthalmology
Disclosure: Nothing to disclose.

Medical Editor

Fernando H Murillo-Lopez, MD, Senior Surgeon, Unidad Privada de Oftalmologia CEMES
Fernando H Murillo-Lopez, MD is a member of the following medical societies: American Academy of Ophthalmology
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Christopher J Rapuano, MD, Professor, Department of Ophthalmology, Jefferson Medical College of Thomas Jefferson University; Co-Chairman of the Cornea Service, Co-Chairman of Refractive Surgery Department, Wills Eye Institute
Christopher J Rapuano, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Cataract and Refractive Surgery, Eye Bank Association of America, Pennsylvania Medical Society, and Philadelphia County Medical Society
Disclosure: Allergan Honoraria Speaking and teaching; Allergan Consulting fee Consulting; Alcon Honoraria Speaking and teaching; Inspire Honoraria Speaking and teaching; RPS Ownership interest Other

CME Editor

Ralph Garzia, OD, Assistant Dean for Clinical Programs, Associate Professor, School of Optometry, University of Missouri at St Louis
Ralph Garzia, OD is a member of the following medical societies: American Academy of Optometry and American Optometric Association
Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD, Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences
Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology
Disclosure: Nothing to disclose.

 
 
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