eMedicine Specialties > Ophthalmology > Extraocular Muscles
Nystagmus, Acquired: Follow-up
Updated: Aug 18, 2009
Follow-up
Further Outpatient Care
- Regular office visits are useful to monitor nystagmus.
Prognosis
- Prognosis is dependent upon etiology.
Miscellaneous
Medicolegal Pitfalls
- The principal medical/legal pitfall in the management of acquired nystagmus is related to misdiagnosis of a serious or life-threatening etiology. Life-threatening causes of nystagmus should first be ruled out with a pertinent history and physical examination. Appropriate consultation and/or imaging should be obtained without delay if a serious underlying cause is suspected.
Special Concerns
- Bruns nystagmus
- The first manifestation of slow-growing cerebello-pontine angle tumors (eg, acoustic neurinoma, exophytic brain stem glioma, cerebellar tumors, metastases) may be a vestibular nystagmus associated with peripheral vestibular symptoms. Peripheral vestibular nystagmus has a horizontal jerk component with the fast phase directed away from the side of the lesion. In addition, an ipsilateral, slow, gaze-evoked nystagmus with gaze to the side of the lesion may be seen as the tumor expands to compress the brain stem. A small amplitude rapid jerk nystagmus in primary position with the fast phase directed away from the side of the lesion in combination with a slow, gaze-evoked nystagmus directed toward the side of the lesion suggests a mass compressing the brain stem with peripheral vestibular nerve involvement. This is known as Bruns nystagmus.
- Acquired nystagmus most often is a result of vestibular dysfunction. A resting tone is present in the vestibular system, even when the head is at rest. Therefore, any loss of neural activity on either side from a pathologic process (eg, mass lesion, ischemia) results in a relative overexcitation of the contralateral side, causing the eyes to drift toward the side of the lesion (ie, nystagmus with the fast phase away from the lesion).
More on Nystagmus, Acquired |
| Overview: Nystagmus, Acquired |
| Differential Diagnoses & Workup: Nystagmus, Acquired |
| Treatment & Medication: Nystagmus, Acquired |
Follow-up: Nystagmus, Acquired |
| References |
| Further Reading |
| « Previous Page |
References
Rucker JC. An update on acquired nystagmus. Semin Ophthalmol. Mar-Apr 2008;23(2):91-7. [Medline].
Sarvananthan N, Surendran M, Roberts E, et al. The prevalence of nystagmus: The Leicestershire nystagmus survey. Invest Ophthalmol Vis Sci. May 20 2009;[Medline].
Wagner JN, Glaser M, Brandt T, Strupp M. Downbeat nystagmus: aetiology and comorbidity in 117 patients. J Neurol Neurosurg Psychiatry. Jun 2008;79(6):672-7. [Medline].
Daroff RB, Troost BT. Upbeat nystagmus. JAMA. Jul 16 1973;225(3):312. [Medline].
Gonzalez C, Seth RK, Ramos-Esteban JC. Change in head posture and character of nystagmus in a patient with neurological upbeat nystagmus. Binocul Vis Strabismus Q. 2007;22(3):179-84. [Medline].
Spielmann AC. Large recession of the four vertical rectus muscles for acquired pendular vertical nystagmus and oscillopsia without a null zone. J AAPOS. Feb 2009;13(1):102-4. [Medline].
Thurtell MJ, Weber KP, Halmagyi GM. Teaching video NeuroImage: acquired or congenital gaze-evoked nystagmus?. Neurology. Jun 3 2008;70(23):e96. [Medline].
Murofushi T, Chihara Y, Ushio M, Iwasaki S. Periodic alternating nystagmus in Meniere's disease: the peripheral type?. Acta Otolaryngol. Jul 2008;128(7):824-7. [Medline].
Menon GJ, Thaller VT. Therapeutic external ophthalmoplegia with bilateral retrobulbar botulinum toxin- an effective treatment for acquired nystagmus with oscillopsia. Eye. Nov 2002;16(6):804-6. [Medline].
Castillo IG, Reinecke RD, Sergott RC, Wizov S. Surgical treatment of trauma-induced periodic alternating nystagmus. Ophthalmology. Jan 2004;111(1):180-3. [Medline].
Kumar A, Thomas S, McLean R, et al. Treatment of acquired periodic alternating nystagmus with memantine: a case report. Clin Neuropharmacol. Mar-Apr 2009;32(2):109-10. [Medline].
American Academy of Ophthalmology. Basic and Clinical Science Course. In: Neuro-ophthalmology. 5. 1999-2000:139-41.
American Academy of Ophthalmology. Basic and Clinical Science Course. In: Pediatric. 69(3). 1999-2000:129-35.
American Medical Association. Drug Evaluations. 1995.
Arnoldi KA, Tychsen L. Prevalence of intracranial lesions in children initially diagnosed with disconjugate nystagmus (spasmus nutans). J Pediatr Ophthalmol Strabismus. Sep-Oct 1995;32(5):296-301. [Medline].
Averbuch-Heller L, Tusa RJ, Fuhry L, et al. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann Neurol. Jun 1997;41(6):818-25. [Medline].
Baloh RW, Spooner JW. Downbeat nystagmus: a type of central vestibular nystagmus. Neurology. Mar 1981;31(3):304-10. [Medline].
Breen LA. Nystagmus and related ocular oscillations. In: Neuroophthalmology: Clinical Signs and Symptoms. Vol 4. 1997:504-20.
Cross SA, Smith JL, Norton EW. Periodic alternating nystagmus clearing after vitrectomy. J Clin Neuroophthalmol. Mar 1982;2(1):5-11. [Medline].
Donin JF. Acquired monocular nystagmus in children. Can J Ophthalmol. Jul 1967;2(3):212-5. [Medline].
Glaser JS. Neuro-Ophthalmology. 1990.
Leigh RJ, Robinson DA, Zee DS. A hypothetical explanation for periodic alternating nystagmus: instability in the optokinetic-vestibular system. Ann N Y Acad Sci. 1981;374:619-35. [Medline].
Martin JH. Neuroanatomy Atlas. 2nd ed. McGraw-Hill Co; 1996:155-61.
May EF, Truxal AR. Loss of vision alone may result in seesaw nystagmus. J Neuroophthalmol. Jun 1997;17(2):84-5. [Medline].
Neely DE, Sprunger DT. Nystagmus. Curr Opin Ophthalmol. Oct 1999;10(5):320-6. [Medline].
Nolte J. The Human Brain. 1993:218-23.
Norton EW, Cogan DG. Spasmus nutans; a clinical study of twenty cases followed two years or more since onset. AMA Arch Ophthalmol. Sep 1954;52(3):442-6. [Medline].
Pratt-Johnson JA, Tillson G. Management of Strabismus and Amblyopia: A Practical Guide. 1994.
Ruben ST, Lee JP, O'Neil D, Dunlop I, Elston JS. The use of botulinum toxin for treatment of acquired nystagmus and oscillopsia. Ophthalmology. Apr 1994;101(4):783-7. [Medline].
Sharpe JA, Lo AW, Rabinovitch HE. Control of the saccadic and smooth pursuit systems after cerebral hemidecortication. Brain. Jun 1979;102(2):387-403. [Medline].
Stahl JS, Averbuch-Heller L, Leigh RJ. Acquired nystagmus. Arch Ophthalmol. Apr 2000;118(4):544-9. [Medline].
Troost BT. Nystagmus and Related Ocular Oscillations. Available at: http://www.wfubmc.edu. 1998;[Full Text].
Tusa RJ. Nystagmus: diagnostic and therapeutic strategies. Semin Ophthalmol. Jun 1999;14(2):65-73. [Medline].
Tychsen L. Pediatric Ocular Motility Disorders of Neuro-ophthalmic Significance. Vol. 4. 1991:615-43.
Van Stavern GP, Biousse V, Newman NJ, Leingang JC. Downbeat nystagmus from heat stroke. J Neurol Neurosurg Psychiatry. Sep 2000;69(3):403-4. [Medline]. [Full Text].
Further Reading
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Keywords
acquired nystagmus, downbeat nystagmus, upbeat nystagmus, periodic alternating nystagmus, horizontal nystagmus, vertical nystagmus, optokinetic nystagmus, rotary nystagmus, vestibular nystagmus, oscillopsia, congenital nystagmus, spasmus nutans
Follow-up: Nystagmus, Acquired