eMedicine Specialties > Ophthalmology > Genetic Disorders

Aniridia in the Newborn: Follow-up

Author: Sophie Bakri, MD, Assistant Professor of Ophthalmology, Vitreoretinal Diseases and Surgery, Mayo Clinic of Rochester
Coauthor(s): John W Simon, MD, Chair, Department of Ophthalmology, Professor, Departments of Ophthalmology and Pediatrics, Albany Medical College
Contributor Information and Disclosures

Updated: Jun 17, 2009

Follow-up

Further Outpatient Care

  • Patients should be observed by the ophthalmologist as indicated, depending on the complications and their severity.

Inpatient & Outpatient Medications

Complications

  • The complications of aniridia are discussed throughout this article.

Prognosis

  • The prognosis and visual acuity level varies depending on the complications of aniridia. Generalizations cannot be made.

Patient Education

  • The parents of the patient should be educated about the disease. Education should be geared toward maintaining careful follow-up care of the specific ocular complications of aniridia being experienced by the patient.

Miscellaneous

Medicolegal Pitfalls

  • Medical/legal pitfalls relate to mismanagement of the specific complications of aniridia.
 


More on Aniridia in the Newborn

Overview: Aniridia in the Newborn
Differential Diagnoses & Workup: Aniridia in the Newborn
Treatment & Medication: Aniridia in the Newborn
Follow-up: Aniridia in the Newborn
Multimedia: Aniridia in the Newborn
References
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References

  1. Nelson LB, Spaeth GL, Nowinski TS, et al. Aniridia. A review. Surv Ophthalmol. May-Jun 1984;28(6):621-42. [Medline].

  2. Brauner SC, Walton DS, Chen TC. Aniridia. Int Ophthalmol Clin. Spring 2008;48(2):79-85. [Medline].

  3. Callahan A. Aniridia with ectopia lentis and secondary glaucoma. Am J Ophthalmol. 1949;32:28.

  4. Chen TC, Walton DS. Goniosurgery for prevention of aniridic glaucoma. Arch Ophthalmol. Sep 1999;117(9):1144-8. [Medline].

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  7. Hamming N, Wilensky J. Persistent pupillary membrane associated with aniridia. Am J Ophthalmol. Jul 1978;86(1):118-20. [Medline].

  8. Hittner HM, Riccardi VM, Ferrell RE, et al. Variable expressivity in autosomal dominant aniridia by clinical, electrophysiologic, and angiographic criteria. Am J Ophthalmol. Apr 1980;89(4):531-9. [Medline].

  9. Jastaneiah S, Al-Rajhi AA. Association of aniridia and dry eyes. Ophthalmology. Sep 2005;112(9):1535-40. [Medline].

  10. Jesberg DO. Aniridia with retinal lipid deposits. Arch Ophthalmol. Sep 1962;68:331-6. [Medline].

  11. Koroma BM, Yang JM, Sundin OH. The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia. Invest Ophthalmol Vis Sci. Jan 1997;38(1):108-20. [Medline].

  12. Kremer I, Rajpal RK, Rapuano CJ, et al. Results of penetrating keratoplasty in aniridia. Am J Ophthalmol. Mar 15 1993;115(3):317-20. [Medline].

  13. Layman PR, Anderson DR, Flynn JT. Frequent occurrence of hypoplastic optic disks in patients with aniridia. Am J Ophthalmol. Apr 1974;77(4):513-6. [Medline].

  14. Mackman G, Brightbill FS, Optiz JM. Corneal changes in aniridia. Am J Ophthalmol. Apr 1979;87(4):497-502. [Medline].

  15. Margo CE. Congenital aniridia: a histopathologic study of the anterior segment in children. J Pediatr Ophthalmol Strabismus. Sep-Oct 1983;20(5):192-8. [Medline].

  16. Menezo JL, Martinez-Costa R, Cisneros A, et al. Implantation of iris devices in congenital and traumatic aniridias: surgery solutions and complications. Eur J Ophthalmol. Jul-Aug 2005;15(4):451-7. [Medline].

  17. Nishida K, Kinoshita S, Ohashi Y, et al. Ocular surface abnormalities in aniridia. Am J Ophthalmol. Sep 1995;120(3):368-75. [Medline].

  18. Ramaesh K, Ramaesh T, Dutton GN, et al. Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy. Int J Biochem Cell Biol. Mar 2005;37(3):547-57. [Medline].

  19. Warburg M, Mikkelsen M, Andersen SR, et al. Aniridia and interstitial deletion of the short arm of chromosome 11. Metab Pediatr Ophthalmol. 1980;4(2):97-102. [Medline].

  20. Wiggins RE Jr, Tomey KF. The results of glaucoma surgery in aniridia. Arch Ophthalmol. Apr 1992;110(4):503-5. [Medline].

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Further Reading

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Keywords

aniridia, congenital aniridia, aniridia in newborn, iris hypoplasia, absence of iris, iris absence, Wilms tumor, Wilm's tumor, nephroblastoma, WAGR complex, Miller syndrome, pediatric glaucoma, panophthalmic disorder

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Contributor Information and Disclosures

Author

Sophie Bakri, MD, Assistant Professor of Ophthalmology, Vitreoretinal Diseases and Surgery, Mayo Clinic of Rochester
Sophie Bakri, MD is a member of the following medical societies: American Academy of Ophthalmology
Disclosure: Nothing to disclose.

Coauthor(s)

John W Simon, MD, Chair, Department of Ophthalmology, Professor, Departments of Ophthalmology and Pediatrics, Albany Medical College
John W Simon, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Ophthalmology, and American Association for Pediatric Ophthalmology and Strabismus
Disclosure: Nothing to disclose.

Medical Editor

Gerhard W Cibis, MD, Clinical Professor, Director of Pediatric Ophthalmology Service, Department of Ophthalmology, University of Kansas, Kansas City
Gerhard W Cibis, MD is a member of the following medical societies: American Academy of Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, and American Ophthalmological Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

J James Rowsey, MD, Former Director of Corneal Services, St Luke's Cataract and Laser Institute, Florida
J James Rowsey, MD is a member of the following medical societies: American Academy of Ophthalmology, American Association for the Advancement of Science, American Medical Association, Association for Research in Vision and Ophthalmology, Florida Medical Association, Pan-American Association of Ophthalmology, Sigma Xi, and Southern Medical Association
Disclosure: Nothing to disclose.

CME Editor

Lance L Brown, OD, MD, Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri
Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD, Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences
Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology
Disclosure: Nothing to disclose.

 
 
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