Intraocular Tumors and Glaucoma Workup
- Author: Andrew A Dahl, MD; Chief Editor: Hampton Roy Sr, MD more...
Imaging Studies
Differentiation between benign and malignant processes of the choroid can be assisted by MRI and ultrasound evaluation.
Procedures
For tissue diagnosis, fine-needle biopsy, aqueous aspiration, or excisional biopsy is needed.
Diagnosis of iris nevus is aided by fluorescein angiography of iris, aqueous aspiration, or biopsy.
Histologic Findings
Pigmented lesions: Melanoma consists of varying proportions of spindle cells and epithelioid cells, with the latter cell types associated with higher malignant potential. Reports indicate a 17% incidence of glaucoma in ciliary body melanoma, 7% in iris melanoma, and 2% in choroidal melanoma. The predominant mechanism also varies with tumor location.
Shields CL, Shields JA, Shields MB, Augsburger JJ. Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors. Ophthalmology. Jul 1987;94(7):839-46. [Medline].
Jakobiec FA, Silbert G. Are most iris "melanomas' really nevi? A clinicopathologic study of 189 lesions. Arch Ophthalmol. Dec 1981;99(12):2117-32. [Medline].
Sullivan TJ, Clarke MP, Morin JD. The ocular manifestations of the Sturge-Weber syndrome. J Pediatr Ophthalmol Strabismus. Nov-Dec 1992;29(6):349-56. [Medline].
Iwach AG, Hoskins HD Jr, Hetherington J Jr, Shaffer RN. Analysis of surgical and medical management of glaucoma in Sturge-Weber syndrome. Ophthalmology. Jul 1990;97(7):904-9. [Medline].
Jakobiec FA. Intraocular tumors and glaucoma. In: Principles and Practice of Ophthalmology. 1999.
Allen KA, Straatsma BR. Ocular involvement in leukemia and allied disease. Arch Ophthalmol. 1961;66:490-508.
Bianciotto C, Shields CL, Kang B, Shields JA. Treatment of iris melanoma and secondary neovascular glaucoma using bevacizumab and plaque radiotherapy. Arch Ophthalmol. Apr 2008;126(4):578-9. [Medline].
Bloch RS, Gartner S. The incidence of ocular metastatic carcinoma. Arch Ophthalmol. Jun 1971;85(6):673-5. [Medline].
Broughton WL, Zimmerman LE. A clinicopathologic study of 56 cases of intraocular medulloepitheliomas. Am J Ophthalmol. Mar 1978;85(3):407-18. [Medline].
Chan CC, Buggage RR, Nussenblatt RB. Intraocular lymphoma. Curr Opin Ophthalmol. Dec 2002;13(6):411-8. [Medline].
Christensen GR, Records RE. Glaucoma and expulsive hemorrhage mechanisms in the Sturge-Weber syndrome. Ophthalmology. Jul 1979;86(7):1360-6. [Medline].
Cibis GW, Tripathi RC, Tripathi BJ. Glaucoma in Sturge-Weber syndrome. Ophthalmology. Sep 1984;91(9):1061-71. [Medline].
de Leon JM, Walton DS, Latina MA, Mercado GV. Glaucoma in retinoblastoma. Semin Ophthalmol. Oct-Dec 2005;20(4):217-22. [Medline].
de Leon JM, Walton DS, Latina MA, Mercado GV. Glaucoma in retinoblastoma. Semin Ophthalmol. Oct-Dec 2005;20(4):217-22. [Medline].
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA. Iris melanocytoma: clinical features and natural course in 47 cases. Am J Ophthalmol. Mar 2005;139(3):468-75. [Medline].
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG. Diffuse iris melanoma: a report of 25 cases. Ophthalmology. Aug 2002;109(8):1553-60. [Medline].
Detorakis ET, Engstrom RE Jr, Wallace R, Straatsma BR. Iris and anterior chamber angle neovascularization after iodine 125 brachytherapy for uveal melanoma. Ophthalmology. Mar 2005;112(3):505-10. [Medline].
Elgin U, Simsek T, Batman A. Use of the ex-press miniature glaucoma implant in a child with Sturge-Weber syndrome. J Pediatr Ophthalmol Strabismus. Jul-Aug 2007;44(4):248-50. [Medline].
Fonken HA, Ellis PP. Leukemic infiltrates in the iris. Successful treatment of secondary glaucoma with x-irradiation. Arch Ophthalmol. Jul 1966;76(1):32-6. [Medline].
Font RL, Ferry AP. The phakomatoses. Int Ophthalmol Clin. Spring 1972;12(1):1-50. [Medline].
Glaser B, Smith JL. Leukaemic glaucoma. Br J Ophthalmol. Feb 1966;50(2):92-4. [Medline]. [Full Text].
Grant WM, Walton DS. Distinctive gonioscopic findings in glaucoma due to neurofibromatosis. Arch Ophthalmol. Feb 1968;79(2):127-34. [Medline].
Harbour JW, Augsburger JJ, Eagle RC Jr. Initial management and follow-up of melanocytic iris tumors. Ophthalmology. Dec 1995;102(12):1987-93. [Medline].
Kincaid MC, Green WR. Ocular and orbital involvement in leukemia. Surv Ophthalmol. Jan-Feb 1983;27(4):211-32. [Medline].
Marshall CD. On tension in cases of intra-ocular tumour. Trans Ophthalmol Soc UK. 1896;16:155-70.
Radcliffe NM, Finger PT. Eye cancer related glaucoma: current concepts. Surv Ophthalmol. Jan-Feb 2009;54(1):47-73. [Medline].
Rohrbach JM, Grub M, Schlote T. [Neoplastic secondary glaucomas]. Klin Monbl Augenheilkd. Oct 2005;222(10):788-96. [Medline].
Saket RR, Mafee MF. Anterior-segment retinoblastoma mimicking pseudoinflammatory angle-closure glaucoma: review of the literature and the important role of imaging. AJNR Am J Neuroradiol. Sep 2009;30(8):1607-9. [Medline].
Shields JA, Shields CL. Retinoblastoma: Clinical and pathologic features. In: Shields JA, Shields CL, eds. Intraocular Tumors: A Text and Atlas. Philadelphia, Pa: 1992.
Yoshizumi MO, Thomas JV, Smith TR. Glaucoma-inducing mechanisms in eyes with retinoblastoma. Arch Ophthalmol. Jan 1978;96(1):105-10. [Medline].

