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Uveitis, Anterior, Childhood: Differential Diagnoses & Workup

Author: R Christopher Walton, MD, Professor, Director of Uveitis and Ocular Inflammatory Diseases Service, Assistant Department of Ophthalmology, Assistant Dean for Graduate Medical Education and Continuing Education, University of Tennessee College of Medicine; Consulting Staff, Regional Medical Center, Memphis Veterans Affairs Medical Center, St Jude Children's Research Hospital
Contributor Information and Disclosures

Updated: Jan 5, 2008

Differential Diagnoses

Juvenile Xanthogranuloma
Leukemias

Workup

Laboratory Studies

  • If JIA is suspected, obtain an antinuclear antibody test to classify the condition and to determine the risk of recurrent and severe disease.
  • In patients suspected of having AS, reactive arthritis, or inflammatory bowel disease, perform testing for the HLA-B27 haplotype. Sacroiliac joint films may demonstrate evidence of joint involvement in AS and reactive arthritis.
  • Sarcoid uveitis is investigated with determination of the angiotensin-converting enzyme (ACE) level, with or without serum lysozyme testing, chest roentgenograms, and gallium scanning. Remember that normal ACE values in children are higher than those in adults. Definitive diagnosis requires histopathologic demonstration of noncaseating granulomatous inflammation, in the absence of another possible cause.
  • Antistreptococcal lysin O titers are indicated in patients with possible poststreptococcal syndrome uveitis.

Imaging Studies

  • See Lab Studies.

More on Uveitis, Anterior, Childhood

Overview: Uveitis, Anterior, Childhood
Differential Diagnoses & Workup: Uveitis, Anterior, Childhood
Treatment & Medication: Uveitis, Anterior, Childhood
Follow-up: Uveitis, Anterior, Childhood
References
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References

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Further Reading

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Keywords

anterior uveitis, juvenile idiopathic arthritis, JIA, juvenile rheumatoid arthritis, JRA, ankylosing spondylitis, AS, reactive arthritis, Reiter syndrome, inflammatory bowel disease, IBD, sarcoidosis

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Contributor Information and Disclosures

Author

R Christopher Walton, MD, Professor, Director of Uveitis and Ocular Inflammatory Diseases Service, Assistant Department of Ophthalmology, Assistant Dean for Graduate Medical Education and Continuing Education, University of Tennessee College of Medicine; Consulting Staff, Regional Medical Center, Memphis Veterans Affairs Medical Center, St Jude Children's Research Hospital
R Christopher Walton, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Healthcare Executives, American Uveitis Society, Association for Research in Vision and Ophthalmology, and Retina Society
Disclosure: Nothing to disclose.

Medical Editor

Gerhard W Cibis, MD, Clinical Professor, Director of Pediatric Ophthalmology Service, Department of Ophthalmology, University of Kansas, Kansas City
Gerhard W Cibis, MD is a member of the following medical societies: American Academy of Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, and American Ophthalmological Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Simon K Law, MD, PharmD, Assistant Professor of Ophthalmology, Jules Stein Eye Institute; Chief of Section of Ophthalmology Surgical Services, Department of Veterans Affairs Healthcare Center, West Los Angeles
Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society, and Association for Research in Vision and Ophthalmology
Disclosure: Nothing to disclose.

Managing Editor

Steve Charles, MD, Director of Charles Retina Institute; Clinical Professor, Department of Ophthalmology, University of Tennessee College of Medicine
Steve Charles, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Retina Specialists, Club Jules Gonin, Macula Society, and Retina Society
Disclosure: Alcon Laboratories Consulting fee Consulting; OptiMedica Ownership interest Consulting

CME Editor

Lance L Brown, OD, MD, Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri
Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD, Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences
Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology
Disclosure: Nothing to disclose.

 
 
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