eMedicine Specialties > Ophthalmology > Lacrimal System
Lacrimal Gland Tumors: Follow-up
Updated: Aug 8, 2006
Follow-up
Further Inpatient Care
- Hospitalization may be required if treatment with chemotherapeutic agents is needed.
Prognosis
- For pleomorphic adenomas, long-term studies reveal an increased incidence of malignant transformation (10% at 20 y and 20% at 30 y) associated with multiple recurrences for lesions that had frequent incisional biopsies and incomplete removal of the primary tumor.
- Annual follow-up care is suggested to monitor the effects of treatment and to observe for recurrence or systemic involvement.
- Systemic lymphoma develops in 20-30% of patients with malignant lymphoma of the lacrimal gland. Incidence is much higher if the initial presentation is with bilateral lacrimal gland involvement.
- Adenoid cystic carcinomas carry a poorer prognosis because of bony extension and perineural infiltration.
- These patients have a 50% at 5-year and 75% at 15-year mortality rate. Death commonly is due to intracranial spread and pulmonary metastasis.
- Histologic pattern also is of prognostic significance with a cribriform pattern having a 70% at 5-year survival compared to a 20% at 5-year survival with a basaloid pattern.
Miscellaneous
Medicolegal Pitfalls
- Early detection and treatment decreases the possibility of negative effects.
More on Lacrimal Gland Tumors |
| Overview: Lacrimal Gland Tumors |
| Differential Diagnoses & Workup: Lacrimal Gland Tumors |
| Treatment & Medication: Lacrimal Gland Tumors |
Follow-up: Lacrimal Gland Tumors |
| References |
| « Previous Page |
References
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Farmer JP, Lamba M, Lamba WR, et al. Lymphoproliferative lesions of the lacrimal gland: clinicopathological, immunohistochemical, and molecular genetic analysis. Can J Ophthalmol. 2005;40:151-60. [Medline].
Font RL, Smith SL, Bryan RG. Malignant epithelial tumors of the lacrimal gland: A clinicopathological study of 21 cases. Arch Ophthalmol. 1998;116:613-6. [Medline].
Forrest AW. Pathologic criteria for effective management of epithelial lacrimal gland tumors. Am J Ophthalmol. Jan 1971;1(1 Part 2):178-92. [Medline].
Gamel JW, Font RL. Adenoid cystic carcinoma of the lacrimal gland: the clinical significance of a basaloid histologic pattern. Hum Pathol. Mar 1982;13(3):219-25. [Medline].
Jakobiec FA, Yeo JH, Trokel SL, et al. Combined clinical and computed tomographic diagnosis of primary lacrimal fossa lesions. Am J Ophthalmol. Dec 1982;94(6):785-807. [Medline].
Jenkins C, Rose GE, Bunce C, et al. Clinical features associated with survival of patients with lymphoma of the ocular adnexa. Eye. 2003;17:809-20. [Medline].
Jones IS. Surgical considerations in the management of lacrimal gland tumors. Clin Plast Surg. Oct 1978;5(4):561-9. [Medline].
Mafee MF, Edward DP, Koeller KK, Dorodi S. Lacrimal gland tumors and simulating lesions. Clinicopathologic and MR imaging features. Radiol Clin North Am. Jan 1999;37(1):219-39, xii. [Medline].
Shields JA, Shields CL, Epstein JA, et al. Review: primary epithelial malignancies of the lacrimal gland: the 2003 Ramon L. Font lecture. Ophthal Plast Reconstr Surg. 2004;20:10-21. [Medline].
Stewart WB, Krohel GB, Wright JE. Lacrimal gland and fossa lesions: An approach to diagnosis and management. Ophthalmol. 1979;86:886. [Medline].
Wright JE, Stewart WB, Krohel GB. Clinical presentation and management of lacrimal gland tumors. Br J Ophthalmol. Sep 1979;63(9):600-6. [Medline].
Further Reading
Keywords
neoplastic lesion, orbital lobe, palpebral lobe, epithelial neoplasm
Follow-up: Lacrimal Gland Tumors