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Eyelid Papilloma Follow-up

  • Author: Mounir Bashour, MD, PhD, CM, FRCSC, FACS; Chief Editor: Hampton Roy, Sr, MD  more...
Updated: Mar 21, 2016

Further Outpatient Care

Patients should receive follow-up care as needed.



Surgical scarring and possibly lid notching are the only likely complications. Usually, the lesions are so small that bleeding and infection rarely occur postexcision.

Premalignant, malignant, or benign eyelid skin lesions may be papillomatous.

Cysts - Epidermal inclusion, sudoriferous, sebaceous

Seborrheic keratosis usually occurs in middle-aged or elderly patients and appears as brown-black, "stuck on," well-circumscribed, crustlike lesions. Usually, the lesions are slightly elevated and uninflamed. The lesions can be removed with a shave biopsy, if desired. In black adults, a heavily pigmented variant, dermatosis papulosa nigra, occurs involving the malar region and often the eyelids.

Keratoacanthoma appears similar to basal cell carcinoma and squamous cell carcinoma because it is elevated with a central ulcer crater. However, these dome-shaped tumors with rolled margins usually appear and rapidly grow in size (up to 1-2 cm) over a few weeks to months and then often spontaneously involute. The tumors can be destructive, especially if they involve the eyelash margin. To be sure of the diagnosis, surgical excision and biopsy often is performed. These tumors can occur in individuals who are immunosuppressed (eg, after renal transplantation).

Nevus is usually light to dark brown, but it can be amelanotic and indistinguishable from a squamous papilloma. Usually, it is well circumscribed, sometimes with hair growing from its surface. It does not grow in size.

Inverted follicular keratosis usually presents as a solitary nodular or wartlike keratotic mass, it may be pigmented simulating a melanocytic lesion. It also can present as a cutaneous horn. If incompletely excised, it has a tendency to recur.

Pseudoepitheliomatous hyperplasia often clinically and histopathologically is confused with carcinoma. Usually, it is elevated with an irregular, ulcerated, or crusted surface, mimicking squamous cell carcinoma or basal cell carcinoma. It can occur anywhere on the eyelid and usually is of short duration (weeks to months). They may be associated with mycotic infections, insect bites, drugs, burns, radiation therapy, and underlying malignant lymphoma.



Prognosis is excellent. However, the lesions can recur in the same or different location.


Patient Education

Warn patients to protect their skin from the sun's damaging influence, with hats, sunglasses, and protective lotions, and to minimize exposure to the sun. See a medical practitioner if any new lesions appear.

Contributor Information and Disclosures

Mounir Bashour, MD, PhD, CM, FRCSC, FACS Assistant Professor of Ophthalmology, McGill University Faculty of Medicine; Clinical Assistant Professor of Ophthalmology, Sherbrooke University; Medical Director, Cornea Laser and Lasik MD

Mounir Bashour, MD, PhD, CM, FRCSC, FACS is a member of the following medical societies: American Academy of Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, American College of International Physicians, American College of Surgeons, American Medical Association, American Society of Cataract and Refractive Surgery, American Society of Mechanical Engineers, American Society of Ophthalmic Plastic and Reconstructive Surgery, Biomedical Engineering Society, Canadian Medical Association, Canadian Ophthalmological Society, Contact Lens Association of Ophthalmologists, International College of Surgeons US Section, Ontario Medical Association, Quebec Medical Association, Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

Specialty Editor Board

Simon K Law, MD, PharmD Clinical Professor of Health Sciences, Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, David Geffen School of Medicine

Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, American Glaucoma Society

Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy, Sr, MD Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy, Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Additional Contributors

Brian A Phillpotts, MD, MD 

Brian A Phillpotts, MD, MD is a member of the following medical societies: American Academy of Ophthalmology, American Diabetes Association, American Medical Association, National Medical Association

Disclosure: Nothing to disclose.

  1. Bajaj MS, Aalok L, Gupta V, Sen S, Pushker N, Chandra M. Ultrasound biomicroscopic appearances of eyelid lesions at 50 MHz. J Clin Ultrasound. 2007 Oct. 35(8):424-9. [Medline].

  2. Eshraghi B, Torabi HR, Kasaie A, Rajabi MT. The use of a radiofrequency unit for excisional biopsy of eyelid papillomas. Ophthal Plast Reconstr Surg. 2010 Nov-Dec. 26(6):448-9. [Medline].

  3. Lee BJ, Nelson CC. Intralesional Interferon for Extensive Squamous Papilloma of the Eyelid Margin. Ophthal Plast Reconstr Surg. 2011 Jun 8. [Medline].

  4. Chopdar A. Carbon-dioxide laser treatment of eye lid lesions. Trans Ophthalmol Soc U K. 1985. 104 (Pt 2):176-80. [Medline].

  5. Hilovsky JP. Lid lesions suspected of malignancy. J Am Optom Assoc. 1995 Aug. 66(8):510-5. [Medline].

  6. Kersten RC, Ewing-Chow D, Kulwin DR, Gallon M. Accuracy of clinical diagnosis of cutaneous eyelid lesions. Ophthalmology. 1997 Mar. 104(3):479-84. [Medline].

  7. Khong JJ, Leibovitch I, Selva D, Dodd T, Muecke J. Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma. Clin Experiment Ophthalmol. 2005 Apr. 33(2):197-8. [Medline].

  8. Kikkawa DO, Ochabski R, Weinreb RN. Ultrasound biomicroscopy of eyelid lesions. Ophthalmologica. 2003 Jan-Feb. 217(1):20-3. [Medline].

  9. Korn EL. Use of the carbon dioxide laser for removal of lesions adjacent to the punctum. Ann Ophthalmol. 1990 Jun. 22(6):230-4. [Medline].

  10. Margo CE. Eyelid tumors: accuracy of clinical diagnosis. Am J Ophthalmol. 1999 Nov. 128(5):635-6. [Medline].

  11. Rodriguez-Sains RS. Ophthalmologic oncology: common eyelid tumors. J Dermatol Surg Oncol. 1982 Apr. 8(4):247-53. [Medline].

  12. Rumelt S, Pe'er J, Rubin PA. The clinicopathological spectrum of benign peripunctal tumours. Graefes Arch Clin Exp Ophthalmol. 2005 Feb. 243(2):113-9. [Medline].

  13. Tesluk GC. Eyelid lesions: incidence and comparison of benign and malignant lesions. Ann Ophthalmol. 1985 Nov. 17(11):704-7. [Medline].

  14. Wohlrab TM, Rohrbach JM, Erb C, Schlote T, Knorr M, Thiel HJ. Argon laser therapy of benign tumors of the eyelid. Am J Ophthalmol. 1998 May. 125(5):693-7. [Medline].

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