Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

High HDL Cholesterol (Hyperalphalipoproteinemia) Medication

  • Author: Vibhuti N Singh, MD, MPH, FACC, FSCAI; Chief Editor: George T Griffing, MD  more...
 
Updated: Jul 14, 2016
 
 

Medication Summary

Persons with hyperalphalipoproteinemia are generally asymptomatic. The condition is associated with a lower prevalence of atherosclerosis and requires no treatment.

 
 
Contributor Information and Disclosures
Author

Vibhuti N Singh, MD, MPH, FACC, FSCAI Clinical Assistant Professor, Division of Cardiology, University of South Florida College of Medicine; Director, Cardiology Division and Cardiac Catheterization Lab, Chair, Department of Medicine, Bayfront Medical Center, Bayfront Cardiovascular Associates; President, Suncoast Cardiovascular Research

Vibhuti N Singh, MD, MPH, FACC, FSCAI is a member of the following medical societies: American College of Cardiology, American College of Physicians, American Heart Association, American Medical Association, Florida Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Don S Schalch, MD Professor Emeritus, Department of Internal Medicine, Division of Endocrinology, University of Wisconsin Hospitals and Clinics

Don S Schalch, MD is a member of the following medical societies: American Diabetes Association, American Federation for Medical Research, Central Society for Clinical and Translational Research, Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD Professor Emeritus of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, International Society for Clinical Densitometry, Southern Society for Clinical Investigation, American College of Medical Practice Executives, American Association for Physician Leadership, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical and Translational Research, Endocrine Society

Disclosure: Nothing to disclose.

Additional Contributors

Ghassem Pourmotabbed, MD, MD 

Ghassem Pourmotabbed, MD, MD is a member of the following medical societies: American Diabetes Association, American Federation for Medical Research, Endocrine Society

Disclosure: Nothing to disclose.

References
  1. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001 May 16. 285(19):2486-97. [Medline].

  2. Mora S, Buring JE, Ridker PM, Cui Y. Association of high-density lipoprotein cholesterol with incident cardiovascular events in women, by low-density lipoprotein cholesterol and apolipoprotein b100 levels: a cohort study. Ann Intern Med. 2011 Dec 6. 155(11):742-50. [Medline]. [Full Text].

  3. Ron D, Aviram M, Brook JG. High density lipoprotein in octogenarians. Biochem Med. 1983 Oct. 30(2):253-60. [Medline].

  4. Yamashita S, Maruyama T, Hirano K, et al. Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. Atherosclerosis. 2000. 152(2):271-85. [Medline].

  5. Miller M. Raising an isolated low HDL-C level: why, how, and when?. Cleve Clin J Med. 2003 Jun. 70(6):553-60. [Medline].

  6. Kakafika A, Athyros VG, Tziomalos K, et al. High density lipoprotein cholesterol and statin trials. Curr Med Chem. 2008. 15(22):2265-70. [Medline].

  7. Bermudez V, Cano R, Cano C, et al. Pharmacologic management of isolated low high-density lipoprotein syndrome. Am J Ther. 2008 Jul-Aug. 15(4):377-88. [Medline].

  8. Plengpanich W, Tongkobpetch S, Shotelersuk V, Le Goff W, Khovidhunkit W. Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia. Clin Chim Acta. 2013 Feb 1. 416:92-5. [Medline].

  9. Mendoza S, Lutmer RF, Glueck CJ. Composition of HDL-2 and HDL-3 in familial hyperalphalipoproteinemia. Atherosclerosis. 1976 Oct. 25(1):131-6. [Medline].

  10. Sich D, Saïdi Y, Giral P, et al. Hyperalphalipoproteinemia: characterization of a cardioprotective profile associating increased high-density lipoprotein2 levels and decreased hepatic lipase activity. Metabolism. 1998 Aug. 47(8):965-73. [Medline].

  11. El Khoury P, Plengpanich W, Frisdal E, Le Goff W, Khovidhunkit W, Guerin M. Improved plasma cholesterol efflux capacity from human macrophages in patients with hyperalphalipoproteinemia. Atherosclerosis. 2014 May. 234 (1):193-9. [Medline].

  12. Arai T, Tsukada T, Murase T, et al. Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency. Clin Chim Acta. 2000. 301(1-2):103-17. [Medline].

  13. Ye D, Kraaijeveld AO, Grauss RW, et al. Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes. J Intern Med. 2008 Sep 6. [Medline].

  14. Plengpanich W, Tongkobpetch S, Shotelersuk V, Le Goff W, Khovidhunkit W. Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia. Clin Chim Acta. 2013 Feb 1. 416:92-5. [Medline].

  15. Tietjen I, Hovingh GK, Singaraja RR, Radomski C, Barhdadi A, McEwen J, et al. Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol. PLoS One. 2012. 7(8):e37437. [Medline]. [Full Text].

  16. Mingpeng S, Zongli W. The protective role of high-density lipoproteins in atherosclerosis. Exp Gerontol. 1999. 34(4):539-48. [Medline].

  17. Vigna GB, Satta E, Bernini F, Boarini S, Bosi C, Giusto L, et al. Flow-mediated dilation, carotid wall thickness and HDL function in subjects with hyperalphalipoproteinemia. Nutr Metab Cardiovasc Dis. 2014 Jul. 24(7):777-83. [Medline].

  18. Hirano K, Yamashita S, Kuga Y. Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler Thromb Vasc Biol. 1995 Nov. 15(11):1849-56. [Medline]. [Full Text].

  19. Shanker J, Perumal G, Rao VS, et al. Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. Lipids Health Dis. 2008 Sep 19. 7(1):33. [Medline]. [Full Text].

  20. Marquez Contreras E, Casado Martinez JJ, Sanchez Ramos JL, et al. [Prevalence of hyperalphalipoproteinemia in the general population]. Med Clin (Barc). 1993 May 8. 100(18):699-701. [Medline].

  21. Kucharska-Newton AM, Rosamond WD, Mink PJ, et al. HDL-cholesterol and incidence of breast cancer in the ARIC cohort study. Ann Epidemiol. 2008 Sep. 18(9):671-7. [Medline].

  22. Deiana L, Pes GM, Carru C, et al. Extremely high HDL levels in a patient with multiple symmetric lipomatosis. Clin Chim Acta. 1993 Dec 31. 223(1-2):143-7. [Medline].

  23. Patsch W, Kuisk I, Glueck C. Lipoproteins in familial hyperalphalipoproteinemia. Arteriosclerosis. 1981 Mar-Apr. 1(2):156-61. [Medline].

  24. Glueck CJ, Fallat RW, Millett F. Familial hyperalphalipoproteinemia. Arch Intern Med. 1975 Aug. 135(8):1025-8. [Medline].

  25. van der Steeg WA, Hovingh GK, Klerkx AH, et al. Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians. J Lipid Res. 2007 Mar. 48(3):674-82. [Medline]. [Full Text].

  26. Brousseau ME, Santamarina-Fojo S, Zech LA. Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits. In vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner. J Clin Invest. 1996 Apr 15. 97(8):1844-51. [Medline]. [Full Text].

  27. Gehrisch S, Kostka H, Tiebel M, et al. Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. J Mol Med. 1999. 77(10):728-34. [Medline].

  28. Morrison JA, Khoury P, Laskarzewski P. Hyperalphalipoproteinemia in hypercholesterolemic adults and children. Trans Assoc Am Physicians. 1980. 93:230-43. [Medline].

  29. Saito F. A pedigree of homozygous familial hyperalphalipoproteinemia. Metabolism. 1984 Jul. 33(7):629-33. [Medline].

  30. Tall AR. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J Clin Invest. 1990 Aug. 86(2):379-84. [Medline]. [Full Text].

Previous
Next
 
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.