Blepharochalasis Syndrome Workup

  • Author: Brett S Kotlus, MD, MS; Chief Editor: Hampton Roy Sr, MD   more...
 
Updated: Jul 11, 2011
 

Laboratory Studies

The diagnosis of blepharochalasis syndrome is made through clinical history and physical examination.

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Imaging Studies

Ultrasonography, CT scanning, or MRI may be performed to exclude dysthyroid orbitopathy, idiopathic orbital inflammation, or other processes that could result in eyelid edema. Imaging may be warranted in individuals with atypical clinical presentations.

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Histologic Findings

A biopsy sample of affected skin may reveal immunoglobulin A (IgA) deposits in the dermoepidermal junction with loss of collagen elastic fibers in the dermis. Perivascular inflammatory cells, including lymphocytes, plasma cells, mast cells, histiocytes, and eosinophils, are also present.

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Contributor Information and Disclosures
Author

Brett S Kotlus, MD, MS  Private Practice, Allure Medical Spa; Assistant Clinical Professor, Department of Ophthalmology and Vision Science, University of Arizona Health Sciences Center

Brett S Kotlus, MD, MS is a member of the following medical societies: American Academy of Cosmetic Surgery, American Academy of Ophthalmology, American Society of Ophthalmic Plastic and Reconstructive Surgery, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Specialty Editor Board

Ron W Pelton, MD, PhD  Private Practice, Colorado Springs, Colorado

Ron W Pelton, MD, PhD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, American Society of Ophthalmic Plastic and Reconstructive Surgery, AO Foundation, and Colorado Medical Society

Disclosure: Nothing to disclose.

Simon K Law, MD, PharmD  Associate Professor of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, David Geffen School of Medicine

Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society, and Association for Research in Vision and Ophthalmology

Disclosure: Nothing to disclose.

Mark T Duffy, MD, PhD  Consulting Staff, Division of Oculoplastic, Orbito-facial, Lacrimal and Reconstructive Surgery, Green Bay Eye Clinic, BayCare Clinic; Medical Director, Advanced Cosmetic Solutions, A BayCare Clinic

Mark T Duffy, MD, PhD is a member of the following medical societies: American Academy of Ophthalmology, American Medical Association, American Society of Ophthalmic Plastic and Reconstructive Surgery, Sigma Xi, and Society for Neuroscience

Disclosure: Allergan - Botox Cosmetic Consulting fee Consulting

Lance L Brown, OD, MD  Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri

Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD  Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Acknowledgments

Thanks to Kathleen Duerksen, MD, for contributing the photos.

References

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Bilateral lacrimal gland prolapse in the quiescent stage of blepharochalasis syndrome.
Upper and lower eyelid edema in blepharochalasis syndrome. Notice the left pseudoepicanthal fold.
 
 
 
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