eMedicine Specialties > Endocrinology > Metabolic Disorders

Hypercholesterolemia, Polygenic: Multimedia

Author: Elena Citkowitz, MD, PhD, FACP, Clinical Professor of Medicine, Yale University School of Medicine; Director, Cholesterol Management Center, Director, Cardiac Rehabilitation, Department of Medicine, Hospital of St Raphael
Coauthor(s): William L Isley, MD, Senior Associate Consultant, Associate Professor of Medicine, Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic of Rochester
Contributor Information and Disclosures

Updated: Nov 17, 2009

Multimedia

Relative risk of coronary heart disease (CHD) mor...
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Media file 1: Relative risk of coronary heart disease (CHD) mortality versus baseline serum cholesterol over time in 3 large cohorts of young men. CHA is Chicago Heart Association Detection Project in Industry, PG is Chicago Peoples Gas Company, and MRFIT is Multiple Risk Factor Intervention Trial. Adapted from Stamler, 2000.
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Relative risk of coronary heart disease (CHD) mor...

Relative risk of coronary heart disease (CHD) mortality versus baseline serum cholesterol over time in 3 large cohorts of young men. CHA is Chicago Heart Association Detection Project in Industry, PG is Chicago Peoples Gas Company, and MRFIT is Multiple Risk Factor Intervention Trial. Adapted from Stamler, 2000.

Simplified diagram of cholesterol metabolism. LDL...
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Media file 2: Simplified diagram of cholesterol metabolism. LDL is low-density lipoprotein, VLDL is very low-density lipoprotein, IDL is intermediate-density lipoprotein, HDL is high-density lipoprotein, and LPL is lipoprotein lipase.
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Simplified diagram of cholesterol metabolism. LDL...

Simplified diagram of cholesterol metabolism. LDL is low-density lipoprotein, VLDL is very low-density lipoprotein, IDL is intermediate-density lipoprotein, HDL is high-density lipoprotein, and LPL is lipoprotein lipase.

National Health and Nutrition Examination Survey ...
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Media file 3: National Health and Nutrition Examination Survey data for hypercholesterolemia among American adults.
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National Health and Nutrition Examination Survey ...

National Health and Nutrition Examination Survey data for hypercholesterolemia among American adults.

Angiographic and clinical endpoint trials with st...
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Media file 4: Angiographic and clinical endpoint trials with statins.
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Angiographic and clinical endpoint trials with st...

Angiographic and clinical endpoint trials with statins.

Major coronary heart disease (CHD) clinical endpo...
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Media file 5: Major coronary heart disease (CHD) clinical endpoint studies of primary prevention and stable CHD with statins versus placebo. *not statistically significant. + atorvastatin 10 mg is the comparator rather than placebo. ++ LDL-C in the atorvastatin 80 mg group/LDL-C in the atorvastatin 10 mg group.
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Major coronary heart disease (CHD) clinical endpo...

Major coronary heart disease (CHD) clinical endpoint studies of primary prevention and stable CHD with statins versus placebo. *not statistically significant. + atorvastatin 10 mg is the comparator rather than placebo. ++ LDL-C in the atorvastatin 80 mg group/LDL-C in the atorvastatin 10 mg group.

More on Hypercholesterolemia, Polygenic

Overview: Hypercholesterolemia, Polygenic
Differential Diagnoses & Workup: Hypercholesterolemia, Polygenic
Treatment & Medication: Hypercholesterolemia, Polygenic
Follow-up: Hypercholesterolemia, Polygenic
Multimedia: Hypercholesterolemia, Polygenic
References
Further Reading
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References

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  21. Rossebo AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. Sep 25 2008;359(13):1343-56. [Medline].

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Further Reading

Related eMedicine topics:
 High HDL Cholesterol (Hyperalphalipoproteinemia)
Hypercholesterolemia, Familial
Hypoglycemia [Emergency Medicine]
Hypoglycemia [Endocrinology]
Hypoglycemia [Pediatrics: General Medicine]
Renal Vein Thrombosis [Radiology]
Renal Vein Thrombosis [Vascular Surgery]

Clinical guidelines:
 Ezetimibe for the treatment of primary (heterozygous-familial and non-familial) hypercholesterolaemia.
National Institute for Health and Clinical Excellence (NICE) - National Government Agency [Non-U.S.]. 2007 Nov. 30 pages. NGC:006202

Cardiometabolic risk management in primary care.
Qatif Primary Health Care - National Government Agency [Non-U.S.].  2008. Various pagings. NGC:006689 

Diagnosis and treatment of childhood hypercholesterolaemia.
Finnish Medical Society Duodecim - Professional Association.  2004 Jun 14 (revised 2007 Feb 13). Various pagings. NGC:005813

Clinical trials:
Pediatric Study to Evaluate the Efficacy and Safety of Ezetimibe Monotherapy in Children With Primary Hypercholesterolemia (Study P05522)

Efficacy and Safety Study of Pitavastatin Compared to atoRvastatin in Type 2 dIabeTes Mellitus With Hypercholesterolemia (ESPRIT)

Combination Treatment With Green Tea Extract and Statins in Patients With Hypercholesterolemia (GTE-Stat)

Evaluation of Ezetimibe and Atorvastatin Coadministration Versus Atorvastatin or Rosuvastatin Monotherapy in Japanese Patients With Hypercholesterolemia (Study P06027)

Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE

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Keywords

polygenic hypercholesterolemia, hypercholesterolemia, hyperlipidemia, cholesterol level, high cholesterol, cholesterol lowering foods, familial hypercholesterolemia, nonfamilial hypercholesterolemia, non-familial hypercholesterolemia cholesterol, statins, statin therapy, simvastatin, pravastatin, atorvastatin, coronary heart disease, CHD, atherothrombotic stroke, atherosclerosis, heart disease

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Contributor Information and Disclosures

Author

Elena Citkowitz, MD, PhD, FACP, Clinical Professor of Medicine, Yale University School of Medicine; Director, Cholesterol Management Center, Director, Cardiac Rehabilitation, Department of Medicine, Hospital of St Raphael
Elena Citkowitz, MD, PhD, FACP is a member of the following medical societies: American College of Physicians, American Heart Association, National Lipid Association, and Sigma Xi
Disclosure: Nothing to disclose.

Coauthor(s)

William L Isley, MD, Senior Associate Consultant, Associate Professor of Medicine, Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic of Rochester
William L Isley, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Diabetes Association, American Federation for Medical Research, Endocrine Society, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Medical Editor

Steven R Gambert, MD, MACP, Chairman, Department of Medicine, Physician-in-Chief, Sinai Hospital of Baltimore; Professor of Medicine, Program Director, Internal Medicine Program, Johns Hopkins University School of Medicine
Steven R Gambert, MD, MACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physician Executives, American College of Physicians, American Geriatrics Society, Association of Professors of Medicine, Endocrine Society, and Gerontological Society of America
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Yoram Shenker, MD, Chief of Endocrinology Section, Veterans Affairs Medical Center of Madison; Interim Chief, Associate Professor, Department of Internal Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Wisconsin at Madison
Yoram Shenker, MD is a member of the following medical societies: American Heart Association, Central Society for Clinical Research, and Endocrine Society
Disclosure: Nothing to disclose.

CME Editor

Mark Cooper, MBBS, PhD, FRACP, Head, Diabetes & Metabolism Division, Baker Heart Research Institute, Professor of Medicine, Monash University
Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD, Professor of Medicine, St Louis University School of Medicine
George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Medical Practice Executives, American College of Physician Executives, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical Research, Endocrine Society, International Society for Clinical Densitometry, and Southern Society for Clinical Investigation
Disclosure: Nothing to disclose.

 
 
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