Imaging Studies
If suspicion exists of an organic cause for decreased vision and the ocular examination is normal, then further investigations into retinal or optic nerve causes should be initiated. Studies to perform include imaging of the visual system through CT scan, MRI, and fluorescein angiography to assess the retina.
Other Tests
Although differences in the electrophysiologic responses of normal eyes versus amblyopic eyes have been reported, these techniques remain investigational and the differences are controversial.
Procedures
See Physical.
Histologic Findings
Histologic studies of the lateral geniculate nucleus in kittens with deprivation amblyopia have shown that cells receiving input from the deprived eye were shrunken and atrophied, while cells receiving input from the nondeprived eye were expanded.
American Academy of Ophthalmology. Amblyopia. In: Basic and Clinical Science Course: Pediatric Ophthalmology and Strabismus. 1997: 259-65.
Kushner, BJ. Amblyopia. In: Nelson LB, ed. Harley's Pediatric Ophthalmology. 1998:125-39.
von Noorden GK. Binocular Vision and Ocular Motility: Theory and Management. 1996;216-54.
Lempert P. Retinal area and optic disc rim area in amblyopic, fellow, and normal hyperopic eyes: a hypothesis for decreased acuity in amblyopia. Ophthalmology. Dec 2008;115(12):2259-61. [Medline].
Daw NW. Critical periods and amblyopia. Arch Ophthalmol. Apr 1998;116(4):502-5. [Medline].
Kirschen DG. Understanding Sensory Evaluation. In: Rosenbaum AL, Santiago AP, eds. Clinical Strabismus Management: Principles and Practice. 1999: 22-35.
Lin LK, Uzcategui N, Chang EL. Effect of surgical correction of congenital ptosis on amblyopia. Ophthal Plast Reconstr Surg. Nov-Dec 2008;24(6):434-6. [Medline].
Flynn JT. Amblyopia: its treatment today and its portent for the future. Binocul Vis Strabismus Q. Summer 2000;15(2):109. [Medline].
Flynn JT, Woodruff G, Thompson JR, et al. The therapy of amblyopia: an analysis comparing the results of amblyopia therapy utilizing two pooled data sets. Trans Am Ophthalmol Soc. 1999;97:373-90; discussion 390-5. [Medline].
Flynn JT. 17th annual Frank Costenbader Lecture. Amblyopia revisited. J Pediatr Ophthalmol Strabismus. Jul-Aug 1991;28(4):183-201. [Medline].
Brown SM. Verisyse IOL implantation in a child with anisometropic amblyopia. J Cataract Refract Surg. Jul 2008;34(7):1057-8. [Medline].
Cotter SA, Edwards AR, Wallace DK, et al. Treatment of anisometropic amblyopia in children with refractive correction. Ophthalmology. Jun 2006;113(6):895-903. [Medline].
Wallace DK, Chandler DL, Beck RW, et al. Treatment of bilateral refractive amblyopia in children three to less than 10 years of age. Am J Ophthalmol. Oct 2007;144(4):487-96. [Medline].
Holmes JM, Kraker RT, Beck RW, et al. A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children. Ophthalmology. Nov 2003;110(11):2075-87. [Medline].
Repka MX, Beck RW, Holmes JM, et al. A randomized trial of patching regimens for treatment of moderate amblyopia in children. Arch Ophthalmol. 2003;121:603-11. [Medline].
Scheiman MM, Hertle RW, Beck RW, et al. Randomized trial of treatment of amblyopia in children aged 7 to 17 years. Arch Ophthalmol. Apr 2005;123(4):437-47. [Medline].
Holmes JM, Beck RW, Kraker RT, et al. Risk of amblyopia recurrence after cessation of treatment. J AAPOS. 2004;8:420-8. [Medline].
Pediatric Eye Disease Investigator Group. A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol. 2002;120:268-278. [Medline].
Repka MX, Wallace DK, Beck RW, et al. Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children. Arch Ophthalmol. 2005;123:149-157. [Medline]. [Full Text].
Repka MX, Cotter SA, Beck RW, et al. A randomized trial of atropine regimens for treatment of moderate amblyopia in children. Ophthalmology. 2004;111:2076-85. [Medline].
Scheiman MM, Hertle RW, Kraker RT, et al. Patching vs atropine to treat amblyopia in children aged 7 to 12 years: a randomized trial. Arch Ophthalmol. Dec 2008;126(12):1634-42. [Medline].
Collins RS, McChesney ME, McCluer CA, et al. Occlusion properties of prosthetic contact lenses for the treatment of amblyopia. J AAPOS. Dec 2008;12(6):565-8. [Medline].
Repka MX. How much amblyopia treatment is enough?. Arch Ophthalmol. Jul 2008;126(7):990-1. [Medline].
Levartovsky S, Oliver M, Gottesman N, Shimshoni M. Factors affecting long term results of successfully treated amblyopia: initial visual acuity and type of amblyopia. Br J Ophthalmol. Mar 1995;79(3):225-8. [Medline].
Longmuir SQ, Pfeifer W, Leon A, Olson RJ, Short L, Scott WE. Nine-year results of a volunteer lay network photoscreening program of 147 809 children using a photoscreener in Iowa. Ophthalmology. Oct 2010;117(10):1869-75. [Medline].
Mirabella G, Hay S, Wong AM. Deficits in perception of images of real-world scenes in patients with a history of amblyopia. Arch Ophthalmol. Feb 2011;129(2):176-83. [Medline].
Wallace DK, Edwards AR, Cotter SA, Beck RW, Arnold RW, Astle WF, et al. A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children. Ophthalmology. Jun 2006;113(6):904-12. [Medline].
Taylor K, Powell C, Hatt SR, Stewart C. Interventions for unilateral and bilateral refractive amblyopia. Cochrane Database Syst Rev. Apr 18 2012;4:CD005137. [Medline].

