Compressive Optic Neuropathy Medication
- Author: Jonathan W Kim, MD; Chief Editor: Hampton Roy, Sr, MD more...
Many cases of compressive optic neuropathy (eg, thyroid ophthalmopathy, orbital pseudotumor, lymphoma, sarcoid) will improve at least transiently with steroid treatment. Intravenous steroids may hasten visual recovery. It may be difficult to withdraw steroid treatment from such patients without deterioration of vision.
Biological agents and immune mediators that target specific aspects of disease pathogenesis may have a role in inflammatory and autoimmune processes causing compressive optic neuropathy. However, the efficacy of these drugs has not been well studied.
See Thyroid Ophthalmopathy for details of medical treatment.
Miller NR, Newman NJ, Biousse V. Walsh and Hoyt's Clinical Neuro-Ophthalmology. 6th ed. Lippincott, Williams & Wilkins; 2004.
Schiefer U, Wilhelm H, Hart W. Neuro-ophthalmic presentations of orbital disease. Clinical Neuro-Ophthalmology: A Practical Guide. Wien & New York: Springer; 2007.
Bulters DO, Shenouda E, Evans BT, Mathad N, Lang DA. Visual recovery following optic nerve decompression for chronic compressive neuropathy. Acta Neurochir (Wien). 2009 Apr. 151(4):325-34. [Medline].
Shields AJ, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, Part 1. Ophthalmology. 2004. 111(5):997-1008. [Medline].
Hodson KE, Bowman RJ, Mafwiri M, et al. Low folate status and indoor pollution are risk factors for endemic optic neuropathy in Tanzania. Br J Ophthalmol. 2011 Oct. 95(10):1361-4. [Medline].
Lee AG, Chau FY, Golnik KC, Kardon RH, Wall M. The diagnostic yield of the evaluation for isolated unexplained optic atrophy. Ophthalmology. 2005 May. 112(5):757-9. [Medline].
Thomas KW, Hunninghake GW. Sarcoidosis. JAMA. 2003 Jun 25. 289 (24):3300-3. [Medline].
Alvarez L, Guañabens N, Peris P, Monegal A, Bedini JL, Deulofeu R, et al. Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. J Bone Miner Res. 1995 Mar. 10 (3):458-65. [Medline].
Spoor TC. Atlas of Oculoplastic and Orbital Surgery. Informa Healthcare; 2007.
Phillips ME, Marzban MM, Kathuria SS. Treatment of thyroid eye disease. Curr Treat Options Neurol. 2010 Jan. 12 (1):64-9. [Medline].
Verity DH, Rose GE. Acute thyroid eye disease (TED): principles of medical and surgical management. Eye (Lond). 2013 Mar. 27 (3):308-19. [Medline].