Further Inpatient Care
- If the patient responds to empiric antibiotics and can be switched to oral antibiotics, further care can be provided on an outpatient basis.
Further Outpatient Care
- On outpatient follow-up care, the patient should be evaluated for signs of relapse, including fever, erythema, edema, pain, and vision loss.
- If a history of chronic sinusitis is present, otolaryngology follow-up care should be arranged.
Inpatient & Outpatient Medications
- Amoxicillin/clavulanic acid or intramuscular ceftriaxone - Considered for outpatient treatment in selected patients
- Second- or third-generation cephalosporins - Possible choice for initial empiric therapy
- Penicillinase resistant synthetic penicillin (eg, nafcillin, oxacillin) - If S aureus is suspected
Transfer
- Transfer may be required if otorhinological or ophthalmological specialties are not available.
Deterrence/Prevention
- Topical antibiotics may prevent traumatic lid lacerations from becoming infected and causing cellulitis.
- Adequate treatment of bacterial sinusitis may prevent spread to adjacent tissues.
Complications
- Infection may spread along tissue planes to cause subperiosteal abscess, orbital abscess, and cavernous sinus thrombosis.
- In a study of pediatric patients with intracranial infection, high-risk features included the following: age older than 7 years, subperiosteal abscess, and headache[8] and fever persisting despite IV antibiotics.
- Patients who are immunocompromised have a higher likelihood of developing fungal infections, which can rapidly become fatal. Aggressive management, including imaging studies of the brain and early IV therapy along with having a low index of suspicion, is indicated for these patients.
Prognosis
- If identified and treated promptly, the prognosis for complete recovery without complication is excellent.
Patient Education
- Patients should be instructed that loss of vision or pain with eye movements is an indication that the infection has spread to the orbit and may necessitate surgical intervention.
- For excellent patient education resources, see eMedicine's Diabetes Center. Also, visit eMedicine's patient education article, Cellulitis.
Artac H, Silahli M, Keles S, Ozdemir M, Reisli I. A rare cause of preseptal cellulitis: anthrax. Pediatr Dermatol. May-Jun 2007;24(3):330-1. [Medline].
Chaudhry IA, Shamsi FA, Elzaridi E, Al-Rashed W, Al-Amri A, Arat YO. Inpatient preseptal cellulitis: experience from a tertiary eye care centre. Br J Ophthalmol. Oct 2008;92(10):1337-41. [Medline].
Babar TF, Zaman M, Khan MN, Khan MD. Risk factors of preseptal and orbital cellulitis. J Coll Physicians Surg Pak. Jan 2009;19(1):39-42. [Medline].
Finger Basak SA, Berk DR, Lueder GT, Bayliss SJ. Common features of periocular tinea. Arch Ophthalmol. Mar 2011;129(3):306-9. [Medline].
Ho CF, Huang YC, Wang CJ, Chiu CH, Lin TY. Clinical analysis of computed tomography-staged orbital cellulitis in children. J Microbiol Immunol Infect. Dec 2007;40(6):518-24. [Medline].
Liu IT, Kao SC, Wang AG, Tsai CC, Liang CK, Hsu WM. Preseptal and orbital cellulitis: a 10-year review of hospitalized patients. J Chin Med Assoc. Sep 2006;69(9):415-22. [Medline].
Yang M, Quah BL, Seah LL, Looi A. Orbital cellulitis in children-medical treatment versus surgical management. Orbit. 2009;28(2-3):124-36. [Medline].
Murthum K, Pogorelov P, Bergua A. [Preseptal cellulitis as a complication of surgical treatment of migraine headaches]. Klin Monatsbl Augenheilkd. Jul 2009;226(7):572-3. [Medline].
Adams WG, Deaver KA, Cochi SL, Plikaytis BD, Zell ER, Broome CV, et al. Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era. JAMA. Jan 13 1993;269(2):221-6. [Medline].
Agarwal M, Biswas J, S K, Shanmugam MP. Retinoblastoma presenting as orbital cellulitis: report of four cases with a review of the literature. Orbit. Jun 2004;23(2):93-8. [Medline].
Ambati BK, Ambati J, Azar N, Stratton L, Schmidt EV. Periorbital and orbital cellulitis before and after the advent of Haemophilus influenzae type B vaccination. Ophthalmology. Aug 2000;107(8):1450-3. [Medline].
Barone SR, Aiuto LT. Periorbital and orbital cellulitis in the Haemophilus influenzae vaccine era. J Pediatr Ophthalmol Strabismus. Sep-Oct 1997;34(5):293-6. [Medline].
Donahue SP, Schwartz G. Preseptal and orbital cellulitis in childhood. A changing microbiologic spectrum. Ophthalmology. Oct 1998;105(10):1902-5; discussion 1905-6. [Medline].
Eustis HS, Armstrong DC, Buncic JR, Morin JD. Staging of orbital cellulitis in children: computerized tomography characteristics and treatment guidelines. J Pediatr Ophthalmol Strabismus. Sep-Oct 1986;23(5):246-51. [Medline].
Hirsch M, Lifshitz T. Computerized tomography in the diagnosis and treatment of orbital cellulitis. Pediatr Radiol. 1988;18(4):302-5. [Medline].
Hu G, Wang MJ, Miller MJ, Holland GN, Bruckner DA, Civen R, et al. Ocular vaccinia following exposure to a smallpox vaccinee. Am J Ophthalmol. Mar 2004;137(3):554-6. [Medline].
Jackson K, Baker SR. Periorbital cellulitis. Head Neck Surg. Mar-Apr 1987;9(4):227-34. [Medline].
Jacobs D, Galetta S. Diagnosis and management of orbital pseudotumor. Curr Opin Ophthalmol. Dec 2002;13(6):347-51. [Medline].
Malinow I, Powell KR. Periorbital cellulitis. Pediatr Ann. Apr 1993;22(4):241-6. [Medline].
McCarty ML, Wilson MW, Fleming JC, Thompson JW, Sandlund JT, Flynn PM, et al. Manifestations of fungal cellulitis of the orbit in children with neutropenia and fever. Ophthal Plast Reconstr Surg. May 2004;20(3):217-23. [Medline].
Molarte AB, Isenberg SJ. Periorbital cellulitis in infancy. J Pediatr Ophthalmol Strabismus. Sep-Oct 1989;26(5):232-4; discussion 235. [Medline].
Reynolds DJ, Kodsi SR, Rubin SE, Rodgers IR. Intracranial infection associated with preseptal and orbital cellulitis in the pediatric patient. J AAPOS. Dec 2003;7(6):413-7. [Medline].
Ruttum MS, Ogawa G. Adenovirus conjunctivitis mimics preseptal and orbital cellulitis in young children. Pediatr Infect Dis J. Mar 1996;15(3):266-7. [Medline].
Schwartz GR, Wright SW. Changing bacteriology of periorbital cellulitis. Ann Emerg Med. Dec 1996;28(6):617-20. [Medline].
Soysal HG, Kiratli H, Recep OF. Anthrax as the cause of preseptal cellulitis and cicatricial ectropion. Acta Ophthalmol Scand. Apr 2001;79(2):208-9. [Medline].
Weiss A, Friendly D, Eglin K, Chang M, Gold B. Bacterial periorbital and orbital cellulitis in childhood. Ophthalmology. Mar 1983;90(3):195-203. [Medline].

