eMedicine Specialties > Ophthalmology > Retina

Nonpseudophakic Cystoid Macular Edema: Follow-up

Author: Daniel B Roth, MD, Assistant Clinical Professor, Department of Ophthalmology, University of Medicine and Dentistry of New Jersey
Contributor Information and Disclosures

Updated: Jan 4, 2008

Follow-up

Further Outpatient Care

  • Typically, patients with CME are evaluated 1-3 months after intervention to evaluate the efficacy of treatment.

Complications

  • Complications associated with the treatment of CME are infrequent. When a posterior sub-Tenon injection of triamcinolone is given, patients can occasionally experience a transient ptosis or subconjunctival hemorrhage. Retinal arterial occlusion after sub-Tenon steroid injections has been reported due to intravascular injection of the drug.
  • Intravitreal triamcinolone has been associated with ocular hypertension, cataract progression, retinal tear or detachment, infectious and noninfectious endophthalmitis, and lens damage.

Prognosis

  • Visual prognosis in eyes with CME depends on the etiology of the CME. If the CME resolves with treatment, visual acuity of 20/40 or better is common. However, in long-standing CME, vision is often 20/100 to 20/200.

Miscellaneous

Medicolegal Pitfalls

  • Failure to recognize CME can lead to failure to diagnose an associated disease. This can severely limit the visual prognosis if the condition is treatable. Usually, a characteristic fundus appearance allows the ophthalmologist to recognize conditions associated with CME, such as diabetic retinopathy, branch vein occlusion, or an epiretinal membrane. However, in the absence of an obvious associated condition, especially in a phakic eye, care should be taken to rule out such pathology as uveitis or a tumor. Missing such a diagnosis can have devastating consequences.
  • The use of commercially available triamcinolone acetonide is not approved for intraocular injection; however, triamcinolone acetonide is commonly used at the discretion of the treating physician as an off-label use. This use has become accepted clinical practice and has an acceptably low-risk profile. Nevertheless, specific ophthalmic preparations of triamcinolone and other long-acting steroid implants are being developed.
 


More on Nonpseudophakic Cystoid Macular Edema

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References

References

  1. Moroi SE, Gottfredsdottir MS, Schteingart MT, Elner SG, Lee CM, Schertzer RM, et al. Cystoid macular edema associated with latanoprost therapy in a case series of patients with glaucoma and ocular hypertension. Ophthalmology. May 1999;106(5):1024-9. [Medline].

  2. Altintas O, Yuksel N, Karabas VL, Demirci G. Cystoid macular edema associated with latanoprost after uncomplicated cataract surgery. Eur J Ophthalmol. Jan-Feb 2005;15(1):158-61. [Medline].

  3. Antcliff RJ, Spalton DJ, Stanford MR, Graham EM, ffytche TJ, Marshall J. Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study. Ophthalmology. Apr 2001;108(4):765-72. [Medline].

  4. Boscia F, Furino C, Dammacco R. Intravitreal triamcinolone acetonide in refractory pseudophakic cystoid macular edema: functional and anatomic results. Eur J Ophthalmol. Jan-Feb 2005;15(1):89-95. [Medline].

  5. Callanan D, Fellman RL, Savage JA. Latanoprost-associated cystoid macular edema. Am J Ophthalmol. Jul 1998;126(1):134-5. [Medline].

  6. Conway MD, Canakis C, Livir-Rallatos C. Intravitreal triamcinolone acetonide for refractory chronic pseudophakic cystoid macular edema. J Cataract Refract Surg. Jan 2003;29(1):27-33. [Medline].

  7. Falcone PM. Vitreomacular traction syndrome confused with pseudophakic cystoid macular edema. Ophthalmic Surg Lasers. May 1996;27(5):392-4. [Medline].

  8. Feldman RB, Mayo SS, Robertson DM, Jones JD, Rostvold JA. Epiretinal membranes and cystoid macular edema in gyrate atrophy of the choroid and retina. Retina. 1989;9(2):139-42. [Medline].

  9. Fung WE. Retina. In: Other causes of cystoid macular edema and retinal trauma after surgery. 2(2). 1994:1811-7.

  10. Gregori NZ, Rosenfeld PJ, Puliafito CA, Flynn HW Jr, Lee JE, Mavrofrides EC, et al. One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. Retina. Oct 2006;26(8):889-95. [Medline].

  11. Halperin LS, Goldman HB. Cystoid macular edema associated with topical echothiophate iodide. Ann Ophthalmol. Dec 1993;25(12):457-8. [Medline].

  12. Heckenlively JR, Jordan BL, Aptsiauri N. Association of antiretinal antibodies and cystoid macular edema in patients with retinitis pigmentosa. Am J Ophthalmol. May 1999;127(5):565-73. [Medline].

  13. Heier JS, Steinert RF, Frederick AR Jr. Cystoid macular edema associated with latanoprost use. Arch Ophthalmol. May 1998;116(5):680-2. [Medline].

  14. Hirakawa H, Iijima H, Gohdo T, Tsukahara S. Optical coherence tomography of cystoid macular edema associated with retinitis pigmentosa. Am J Ophthalmol. Aug 1999;128(2):185-91. [Medline].

  15. Igarashi H, Igarashi S, Ishiko S, Fukui K, Yoshida A. Cystoid macular edema as an initial symptom of inflammatory orbital pseudotumor. Ophthalmologica. 1997;211(4):236-41. [Medline].

  16. Ikeda T, Sato K, Katano T, Hayashi Y. Attached posterior hyaloid membrane and the pathogenesis of honeycombed cystoid macular edema in patients with diabetes. Am J Ophthalmol. Apr 1999;127(4):478-9. [Medline].

  17. Ip MS, Gottlieb JL, Kahana A, Scott IU, Altaweel MM, Blodi BA, et al. Intravitreal triamcinolone for the treatment of macular edema associated with central retinal vein occlusion. Arch Ophthalmol. Aug 2004;122(8):1131-6. [Medline].

  18. Jonas JB, Akkoyun I, Kamppeter B, Kreissig I, Degenring RF. Branch retinal vein occlusion treated by intravitreal triamcinolone acetonide. Eye. Jan 2005;19(1):65-71. [Medline].

  19. Kersten AJ, Althaus C, Best J, Sundmacher R. Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. Graefes Arch Clin Exp Ophthalmol. Nov 1999;237(11):893-6. [Medline].

  20. Kim BY, Smith SD, Kaiser PK. Optical coherence tomographic patterns of diabetic macular edema. Am J Ophthalmol. Sep 2006;142(3):405-12. [Medline].

  21. Lee ST, Friedman SM, Rubin ML. Cystoid macular edema secondary to juxtafoveolar telangiectasis in Coats' disease. Ophthalmic Surg. Apr 1991;22(4):218-21. [Medline].

  22. Loeffler KU, Li ZL, Fishman GA, Tso MO. Dominantly inherited cystoid macular edema. A histopathologic study. Ophthalmology. Sep 1992;99(9):1385-92. [Medline].

  23. Maguire AM, Nichols CW, Crooks GW. Visual loss in cytomegalovirus retinitis caused by cystoid macular edema in patients without the acquired immune deficiency syndrome. Ophthalmology. Apr 1996;103(4):601-5. [Medline].

  24. McDonnell PJ, Ryan SJ, Walonker AF, Miller-Scholte A. Prediction of visual acuity recovery in cystoid macular edema. Ophthalmic Surg. May 1992;23(5):354-8. [Medline].

  25. Meyer CH. Current treatment approaches in diabetic macular edema. Ophthalmologica. 2007;221(2):118-31. [Medline].

  26. Michael JC, De Venecia G. Retinal trypsin digest study of cystoid macular edema associated with peripheral choroidal melanoma. Am J Ophthalmol. Feb 1995;119(2):152-6. [Medline].

  27. Mishima H, Masuda K, Miyake K. The putative role of prostaglandins in cystoid macular edema. Prog Clin Biol Res. 1989;312:251-64. [Medline].

  28. Park CH, Jaffe GJ, Fekrat S. Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol. Sep 2003;136(3):419-25. [Medline].

  29. Park DW, Folk JC, Whitcup SM, Polk TD, Kansupada K, Fountain C, et al. Phakic patients with cystoid macular edema, retinal periphlebitis, and vitreous inflammation. Arch Ophthalmol. Aug 1998;116(8):1025-9. [Medline].

  30. Rabena MD, Pieramici DJ, Castellarin AA, Nasir MA, Avery RL. Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to branch retinal vein occlusion. Retina. Apr-May 2007;27(4):419-25. [Medline].

  31. Remky A, Beausencourt E, Hartnett ME, Trempe CL, Arend O, Elsner AE. Infrared imaging of cystoid macular edema. Graefes Arch Clin Exp Ophthalmol. Nov 1999;237(11):897-901. [Medline].

  32. Rocha G, Deschênes J. Pathophysiology and treatment of cystoid macular edema. Can J Ophthalmol. Oct 1996;31(6):282-8. [Medline].

  33. Rumelt S, Kraus E, Rehany U. Retinal neovascularization and cystoid macular edema in punctata albescens retinopathy. Am J Ophthalmol. Oct 15 1992;114(4):507-8. [Medline].

  34. Schubert HD. Cystoid macular edema: the apparent role of mechanical factors. Prog Clin Biol Res. 1989;312:277-91. [Medline].

  35. Silverstein BE, Smith JH, Sykes SO, Jones MR, Schwartz D, Cunningham ET Jr. Cystoid macular edema associated with cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Am J Ophthalmol. Mar 1998;125(3):411-5. [Medline].

  36. Thach AB, Dugel PU, Flindall RJ, Sipperley JO, Sneed SR. A comparison of retrobulbar versus sub-Tenon's corticosteroid therapy for cystoid macular edema refractory to topical medications. Ophthalmology. Dec 1997;104(12):2003-8. [Medline].

  37. van Kooij B, Rothova A, de Vries P. The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. Ocul Immunol Inflamm. Apr 2006;14(2):73-85. [Medline].

  38. Weene LE. Cystoid macular edema after scleral buckling responsive to acetazolamide. Ann Ophthalmol. Nov 1992;24(11):423-4. [Medline].

  39. Welzl-Hinterkorner E, Tholen H, Sturmer J, Opravil M, Bernauer W. [Bilateral cystoid macular edema after successful treatment of AIDS-associated cytomegalovirus retinitis]. Ophthalmologe. Feb 1999;96(2):87-91. [Medline].

  40. Whitcup SM, Csaky KG, Podgor MJ, Chew EY, Perry CH, Nussenblatt RB. A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. Ophthalmology. Jul 1996;103(7):1054-62; discussion 1062-3. [Medline].

  41. Yepremyan M, Wertz FD, Tivnan T, Eversman L, Marx JL. Early treatment of cystoid macular edema secondary to branch retinal vein occlusion with intravitreal triamcinolone acetonide. Ophthalmic Surg Lasers Imaging. Jan-Feb 2005;36(1):30-6. [Medline].

Further Reading

Keywords

nonpseudophakic CME, cystoid macular edema, CME, macular edema, non-pseudophakic cystoid macular edema, non-pseudophakic CME, Irvine-Gass syndrome, macula, vision loss

Contributor Information and Disclosures

Author

Daniel B Roth, MD, Assistant Clinical Professor, Department of Ophthalmology, University of Medicine and Dentistry of New Jersey
Daniel B Roth, MD is a member of the following medical societies: American Academy of Ophthalmology, American Medical Association, and American Society of Retina Specialists
Disclosure: Nothing to disclose.

Medical Editor

Vytautas A Pakainis, MD, Chief of Ophthalmology, Dorn Veterans Administration Medical Center, Professor of Ophthalmology, Ophthalmology, University of South Carolina School of Medicine
Vytautas A Pakainis, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and South Carolina Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Simon K Law, MD, PharmD, Assistant Professor of Ophthalmology, Jules Stein Eye Institute; Chief of Section of Ophthalmology Surgical Services, Department of Veterans Affairs Healthcare Center, West Los Angeles
Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society, and Association for Research in Vision and Ophthalmology
Disclosure: Nothing to disclose.

Managing Editor

Steve Charles, MD, Director of Charles Retina Institute; Clinical Professor, Department of Ophthalmology, University of Tennessee College of Medicine
Steve Charles, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Retina Specialists, Club Jules Gonin, Macula Society, and Retina Society
Disclosure: Alcon Laboratories Consulting fee Consulting

CME Editor

Lance L Brown, OD, MD, Ophthalmologist, Affiliated With Freeman Hospital and St John's Hospital, Regional Eye Center, Joplin, Missouri
Disclosure: Nothing to disclose.

Chief Editor

Hampton Roy Sr, MD, Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences
Hampton Roy Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, and Pan-American Association of Ophthalmology
Disclosure: Nothing to disclose.

 
 
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