- Author: Hampton Roy, Sr, MD; Chief Editor: John D Sheppard, Jr, MD, MMSc more...
All patients should undergo a thorough history, including a review of systems. Results of this review and findings from the physical examination are used to determine the need for specific laboratory studies. In most patients with mild self-limited disease, laboratory studies are not useful.
Some patients with an unremarkable review of systems may benefit from a limited workup. This includes patients with nodular episcleritis or those with severe and recurrent/persistent simple episcleritis. Useful laboratory studies in this group of patients include serum uric acid, complete blood count with differential, antinuclear antibody, rheumatoid factor, erythrocyte sedimentation rate, Venereal Disease Research Laboratory (VDRL) test, fluorescent treponemal antibody absorption (FTA-ABS) test, and chest x-ray.
Histologic findings include nongranulomatous inflammation with perivascular infiltrates and vascular dilatation.
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