Immune Response to Implants: Multimedia

References

1. Merritt K, Rodrigo JJ. Immune response to synthetic materials. Sensitization of patients receiving orthopaedic implants. Clin Orthop. May 1996;(326):71-9. [Medline].

2. Goh CL. Prevalence of contact allergy by sex, race and age. Contact Dermatitis. Apr 1986;14(4):237-40. [Medline].

3. Kiec-Swierczynska M. Allergy to chromate, cobalt and nickel in Lodz 1977-1988. Contact Dermatitis. Apr 1990;22(4):229-31. [Medline].

4. Kimber I, Bentley AN, Hilton J. Contact sensitization of mice to nickel sulphate and potassium dichromate. Contact Dermatitis. Nov 1990;23(5):325-30. [Medline].

5. Merritt K. Role of medical materials, both in implant and surface applications, in immune response and in resistance to infection. Biomaterials. Jan 1984;5(1):47-53. [Medline].

6. Moller H. Nickel dermatitis: problems solved and unsolved. Contact Dermatitis. Oct 1990;23(4):217-20. [Medline].

7. Peltonen L. Nickel sensitivity in the general population. Contact Dermatitis. Jan 1979;5(1):27-32. [Medline].

8. Skinner H. Current Diagnosis and Treatment in Orthopaedics. Norwalk, CT: Appleton & Lange;. 1995: 31-5.

9. Sicilia A, Cuesta S, Coma G, Arregui I, Guisasola C, Ruiz E, et al. Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients. Clin Oral Implants Res. Aug 2008;19(8):823-35. [Medline].

10. Deutman R, Mulder TJ, Brian R, Nater JP. Metal sensitivity before and after total hip arthroplasty. J Bone Joint Surg Am. Oct 1977;59(7):862-5. [Medline].

11. Elves MW, Wilson JN, Scales JT, Kemp HBS. Incidence of metal sensitivity in patients with total joint replacements. Br Med J. Nov 15 1975;4(5993):376-8. [Medline].

12. Waterman AH, Schrik JJ. Allergy in hip arthroplasty. Contact Dermatitis. Nov 1985;13(5):294-301. [Medline].

13. Brown GC, Lockshin MD, Salvati EA, Bullough PG. Sensitivity to metal as a possible cause of sterile loosening after cobalt-chromium total hip-replacement arthroplasty. J Bone Joint Surg Am. Mar 1977;59(2):164-8. [Medline].

14. Evans EM. Metal sensitivity as a cause of bone necrosis and loosening of the prosthesis in total joint replacement. J Bone Joint Surg Br. Nov 1974;56-B(4):626-42. [Medline].

15. Goldring SR, Clark CR, Wright TM. The problem in total joint arthroplasty: aseptic loosening. J Bone Joint Surg Am. Jun 1993;75(6):799-801. [Medline].

16. Merritt K, Brown SA. Metal sensitivity reactions to orthopedic implants. Int J Dermatol. Mar 1981;20(2):89-94. [Medline].

17. Huber M, Reinisch G, Trettenhahn G, Zweymüller K, Lintner F. Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces. Acta Biomater. Aug 7 2008;[Medline].

18. Goodman SB. Wear particles, periprosthetic osteolysis and the immune system. Biomaterials. Dec 2007;28(34):5044-8. [Medline].

19. Merritt K, Brown SA. Biological effects of corosion products from metals. In: Fraker A, Griffin C, eds. Corrosion and Degradation of Implanted Materials: Second Symposium. ASTM STP 859. Philadelphia: American Society for Testing and Materials;. 1985: 105-16.

20. Panigutti MA, Merritt K, Bruner RJ, et al. Correlation of allergy, metal levels, implant alloy, and implant damage in patients undergoing revision joint arthroplasties. Trans Soc Biomaterials. 1992;15:7.

21. Rostoker G, Robin J, Binet O, et al. Dermatitis due to orthopaedic implants. A review of the literature and report of three cases. J Bone Joint Surg Am. Dec 1987;69(9):1408-12. [Medline].

22. Szliska C, Raskoski J. Sensitization to nickel, cobalt and chromium in surgical patients. Contact Dermatitis. Nov 1990;23(5):378-9. [Medline].

23. Huber M, Reinisch G, Trettenhahn G, Zweymüller K, Lintner F. Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces. Acta Biomater. Jan 2009;5(1):172-80. [Medline].

24. Carlsson A, Moller H. Implantation of orthopaedic devices in patients with metal allergy. Acta Derm Venereol. 1989;69(1):62-6. [Medline].

25. Rooker GD, Wilkinson JD. Metal sensitivity in patients undergoing hip replacement. A prospective study. J Bone Joint Surg Br. Nov 1980;62-B(4):502-5. [Medline].

26. Brown SA, Merritt K, Mayor MB. Considerations of allergy and mechanics in the selection of orthopaedic implant materials [proceedings]. Bull Hosp Joint Dis. Oct 1977;38(2):67-8. [Medline].

27. Carlsson AS, Magnusson B, Moller H. Metal sensitivity in patients with metal-to-plastic total hip arthroplasties. Acta Orthop Scand. Feb 1980;51(1):57-62. [Medline].

28. Whittingham-Jones PM, Dunstan E, Altaf H, Cannon SR, Revell PA, Briggs TW. Immune Responses in Patients With Metal-on-Metal Hip Articulations A Long-term Follow-up. J Arthroplasty. Apr 14 2008;[Medline].

29. Granchi D, Cenni E, Tigani D, Trisolino G, Baldini N, Giunti A. Sensitivity to implant materials in patients with total knee arthroplasties. Biomaterials. Apr 2008;29(10):1494-500. [Medline].

30. Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg. Feb 13 2008;3:6. [Medline].

31. St John K, ed. Particulate Debris From Medical Implants. ASTM STP 1144. Philadelphia: American Society for Testing and Materials;. 1992.

32. Wright TM, Goodman SB, eds. Implant Wear in Total Joint Replacement: Clinical and Biologic Issues, Material and Design Considerations. Rosemont, IL: American Academy of Orthopaedic Surgeons;. 2001: 61-70.

33. Demoly P, Michel F, Bousquet J. Allergy, Principles and Practice. 5th ed. St Louis, Mo: Mosby-Year Book;. 1998: 430-9.

34. Korenblat P, Wedner J. Allergy Theory and Practice. 2nd ed. Philadelphia: WB Saunders;. 1992: 147-9.

35. Swiontkowski MF, Agel J, Schwappach J, et al. Cutaneous metal sensitivity in patients with orthopaedic injuries. J Orthop Trauma. Feb 2001;15(2):86-9. [Medline].

36. Svejgaard E, Morling N, Svejgaard A, Veien NK. Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test. Acta Derm Venereol. 1978;58(3):245-50. [Medline].

37. Svejgaard E, Thomsen M, Morling N. Lymphocyte transformation in vitro in dermatophytosis. Acta Pathol Microbiol Scand [C]. Dec 1976;84C(6):511-23. [Medline].

38. Secher L, Svejgaard E, Hansen GS. T and B lymphocytes in contact and atopic dermatitis. Br J Dermatol. Nov 1977;97(5):537-41. [Medline].

39. Veien NK, Svejgaard E. Lymphocyte transformation in patients with cobalt dermatitis. Br J Dermatol. Aug 1978;99(2):191-6. [Medline].

40. Veien NK, Svejgaard E, Menne T. In vitro lymphocyte transformation to nickel: a study of nickel-sensitive patients before and after epicutaneous and oral challenge with nickel. Acta Derm Venereol. 1979;59(5):447-51. [Medline].

41. Everness KM, Gawkrodger DJ, Botham PA, Hunter JA. The discrimination between nickel-sensitive and non-nickel-sensitivesubjects by an in vitro lymphocyte transformation test. Br J Dermatol. Mar 1990;122(3):293-8. [Medline].

42. Carando S, Cannas M, Rossi P, Portigliatti-Barbos M. The lymphocytic transformation test (L.T.T.) in the evaluation ofintolerance in prosthetic implants. Ital J Orthop Traumatol. Dec 1985;11(4):475-81. [Medline].

43. Pizzoferrato A, Ciapetti G, Stea S, et al. Cell culture methods for testing biocompatibility. Clin Mater. 1994;15(3):173-90. [Medline].

44. Granchi D, Ciapetti G, Stea S, et al. Evaluation of several immunological parameters in patients with asepticloosening of hip arthroplasty. Chir Organi Mov. Oct-Dec 1995;80(4):399-408. [Medline].

45. Donati ME, Savarino L, Granchi D, et al. The effects of metal corrosion debris on immune system cells. Chir Organi Mov. Oct-Dec 1998;83(4):387-93. [Medline].

46. Hallab N, Jacobs JJ, Black J. Hypersensitivity to metallic biomaterials: a review of leukocyte migrationinhibition assays. Biomaterials. Jul 2000;21(13):1301-14. [Medline].

47. Santavirta S, Konttinen YT, Bergroth V, Gronblad M. Lack of immune response to methyl methacrylate in lymphocyte cultures. Acta Orthop Scand. Feb 1991;62(1):29-32. [Medline].

48. Gordon PM, White MI, Scotland TR. Generalized sensitivity from an implanted orthopaedic antibiotic minichain containing nickel. Contact Dermatitis. Mar 1994;30(3):181-2. [Medline].

49. Cramers M, Lucht U. Metal sensitivity in patients treated for tibial fractures with plates of stainless steel. Acta Orthop Scand. 1977;48(3):245-9. [Medline].

Further Reading

Keywords

immune response to implants, metallic alloys, pacemaker, dental implant, orthopedic implant, implanted orthopedic device, allergic reaction, nickel hypersensitivity, chromium sensitivity, cobalt sensitivity, migration inhibition factor, MIF, lymphocyte transformation testing, LTT proliferation testing, metal hypersensitivity implant hypersensitivity, hypersensitivity reactions, arthroplasty, hip replacement, immunology of transplant rejection

Contributor Information and Disclosures

Author

Steven I Rabin, MD, Clinical Associate Professor, Loyola University Medical Center; Chair, Department of Orthopedic Surgery, Dreyer Medical Clinic
Steven I Rabin, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Fracture Association, AO Foundation, and Orthopaedic Trauma Association
Disclosure: Nothing to disclose.

Coauthor(s)

Carl N Graf, MD, Orthopedic and Spine Surgeon, Illinois Spine Institute
Carl N Graf, MD is a member of the following medical societies: American Medical Association
Disclosure: Nothing to disclose.

William J Hopkinson, MD, FACS, FAAOS, Professor and Vice Chair, Department of Orthopedic Surgery and Rehabilitation, Loyola University; Chief of Joint Replacement Service, Department of Orthopedic Surgery, Loyola University Medical Center
William J Hopkinson, MD, FACS, FAAOS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, American Orthopaedic Association, American Orthopaedic Society for Sports Medicine, Illinois Association of Orthopaedic Surgeons, and Illinois State Medical Society
Disclosure: Nothing to disclose.

Nadim James Hallab, PhD, Assistant Professor, Department of Orthopedic Surgery, Rush-Presbyterian-St Lukes Medical Center
Nadim James Hallab, PhD is a member of the following medical societies: American Association of Immunologists, Orthopaedic Research Society, Sigma Xi, and Society for Leukocyte Biology
Disclosure: Nothing to disclose.

Medical Editor

Jonathan Black, PhD, Professor Emeritus of Bioengineering, Department of Bioengineering, Clemson University
Jonathan Black, PhD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, Orthopaedic Research Society, and Sigma Xi
Disclosure: Stryker Orthopaedics Consulting fee Consulting

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Robert J Nowinski, DO, Clinical Assistant Professor of Orthopaedic Surgery, Ohio State University College of Medicine and Public Health, Ohio University College of Osteopathic Medicine; Private Practice, Orthopedic and Neurological Consultants, Inc, Columbus, Ohio
Robert J Nowinski, DO is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Osteopathic Surgeons, American Medical Association, American Osteopathic Association, Ohio Osteopathic Association, and Ohio State Medical Association
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Jason H Calhoun, MD, FAAOS, Chairman, J Vernon Luck Distinguished Professor, Department of Orthopedic Surgery, University of Missouri
Jason H Calhoun, MD, FAAOS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, and American Orthopaedic Foot and Ankle Society
Disclosure: Nothing to disclose.