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Obesity Differential Diagnoses

  • Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
 
Updated: Jul 06, 2016
 
 

Diagnostic Considerations

Mesomorphic body states, as seen in body builders and people in related occupations (eg, professional wrestling), may be associated with elevated BMIs, but as a result of increased muscle mass rather than excess adiposity. In addition, anasarca may be mistaken for obesity if not carefully evaluated clinically. Other conditions to consider while examining for obesity include the following:

  • Depression
  • Type 2 diabetes mellitus
  • Fatty liver
  • Gastroesophageal reflux disease (GERD)
  • Hirsutism
  • Polygenic hypercholesterolemia
  • Hypothyroidism
  • Insulinoma
  • Kallmann syndrome and idiopathic hypogonadotropic hypogonadism
  • Generalized lipodystrophy
  • Polycystic ovarian disease (Stein-Leventhal syndrome)
  • Cushing syndrome
  • Adiposa dolorosa (Dercum disease)
  • Partial lipodystrophies associated with localized lipohypertrophy

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Osama Hamdy, MD, PhD Medical Director, Obesity Clinical Program, Director of Inpatient Diabetes Program, Joslin Diabetes Center; Assistant Professor of Medicine, Harvard Medical School

Osama Hamdy, MD, PhD is a member of the following medical societies: American Association of Clinical Endocrinologists, American Diabetes Association

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: on advisory panel of Novo-Nordisk Inc, Astra-Zeneca Inc., Metagenics Inc<br/>Received research grant from: Metagenics Inc, USDA Dairy Council <br/>Have a 5% or greater equity interest in: HealthyMation LLC<br/>Received consulting fee from Merck Inc for speaking and teaching; Received consulting fee from Abbott Nutrition for consulting; Received grant/research funds from Metagenics for research support; Received grant/research funds from Neurometrix for research support.

Coauthor(s)

Gabriel I Uwaifo, MD Associate Professor, Section of Endocrinology, Diabetes and Metabolism, Louisiana State University School of Medicine in New Orleans; Adjunct Professor, Joint Program on Diabetes, Endocrinology and Metabolism, Pennington Biomedical Research Center in Baton Rouge

Gabriel I Uwaifo, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians-American Society of Internal Medicine, American Diabetes Association, American Medical Association, American Society of Hypertension, Endocrine Society

Disclosure: Nothing to disclose.

Elif A Oral, MD Associate Professor of Medicine, Medical Director, UMHS Bariatric Surgery Program, Director, Post Bariatric Clinic, Division of Metabolism, Endocrinology and Diabetes (MEND), University of Michigan Medical School

Elif A Oral, MD is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine, American College of Endocrinology, American Diabetes Association, American Medical Association, Endocrine Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

Romesh Khardori, MD, PhD, FACP Professor of Endocrinology, Director of Training Program, Division of Endocrinology, Diabetes and Metabolism, Strelitz Diabetes and Endocrine Disorders Institute, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

Acknowledgements

Romesh Khardori, MD, PhD, FACP Former Professor, Department of Medicine, Former Chief, Division of Endocrinology, Metabolism, and Molecular Medicine, Southern Illinois University School of Medicine

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, and Endocrine Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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Comorbidities of obesity.
Energy balance equation.
Secondary causes of obesity.
 
 
 
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