eMedicine Specialties > Orthopedic Surgery > Hand & Upper Extremity

Dupuytren Contracture: Workup

Author: Steve Lee, MD, Physician in Plastic, Reconstructive, and Hand Surgery, Plastic Surgery, PLLC
Coauthor(s): Michael Baytion, MD, Ohio State University College of Medicine; Derek L Reinke, MD, Consulting Staff, Cary Orthopedic and Sports Medicine Specialists; Yelena Bogdan, Stony Brook University Health Sciences Center School of Medicine (SUNY)
Contributor Information and Disclosures

Updated: Feb 3, 2010

Workup

Laboratory Studies

  • No specific laboratory studies assist in the diagnosis of Dupuytren disease.

Imaging Studies

  • No specific imaging studies assist in the diagnosis of Dupuytren disease.

Histologic Findings

Histologic analyses of lesions resulting from Dupuytren contractures indicate physiologic characteristics of hypertrophic scar formation, including the following: myofibroblastic proliferation with increased water levels, type III collagen, chondroitin sulfate, and reducible cross-linkages. In addition, surrounding areas without clinical manifestations reveal newly formed type III collagen, reducible cross-links, and fibroblasts with myofibroblastic characteristics such as intracellular microfilaments, as well as basement lamina-like condensation. This evidence suggests that Dupuytren disease spreads by migrating along the altered collagen bundles and that clinically silent areas are also affected.18

More on Dupuytren Contracture

Overview: Dupuytren Contracture
Workup: Dupuytren Contracture
Treatment: Dupuytren Contracture
Follow-up: Dupuytren Contracture
References
Further Reading
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References

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Keywords

Dupuytren's disease, Dupuytren disease, fibromatosis, fibromatoses, Dupuytren's contractures, palmar contracture, palmar fascia

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Contributor Information and Disclosures

Author

Steve Lee, MD, Physician in Plastic, Reconstructive, and Hand Surgery, Plastic Surgery, PLLC
Steve Lee, MD is a member of the following medical societies: American College of Surgeons and American Society of Plastic Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Michael Baytion, MD, Ohio State University College of Medicine
Disclosure: Nothing to disclose.

Derek L Reinke, MD, Consulting Staff, Cary Orthopedic and Sports Medicine Specialists
Disclosure: Nothing to disclose.

Yelena Bogdan, Stony Brook University Health Sciences Center School of Medicine (SUNY)
Yelena Bogdan is a member of the following medical societies: Phi Beta Kappa
Disclosure: Nothing to disclose.

Medical Editor

Michael S Clarke, MD, Clinical Associate Professor, Department of Orthopedic Surgery, University of Missouri-Columbia School of Medicine
Michael S Clarke, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Academy of Pediatrics, American Association for Hand Surgery, American College of Surgeons, American Medical Association, Arthroscopy Association of North America, Clinical Orthopaedic Society, Mid-Central States Orthopaedic Society, and Missouri State Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Michael Yaszemski, MD, PhD, Associate Professor, Departments of Orthopedic Surgery and Bioengineering, Mayo Foundation, Mayo Medical School
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD, Consulting Surgeon, Broward Hand Center; Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society
Disclosure: Nothing to disclose.

 
 
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