eMedicine Specialties > Orthopedic Surgery > Hand & Upper Extremity

Dupuytren Contracture: Workup

Author: Steve Lee, MD, Physician in Plastic, Reconstructive, and Hand Surgery, The Samra Group
Coauthor(s): Michael Baytion, BS, Ohio State University College of Medicine; Mark F Hendrickson, MD, Chief, Section of Hand Surgery, Department of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation; Derek L Reinke, MD, Consulting Staff, Cary Orthopedic and Sports Medicine Specialists; Yelena Bogdan, Stony Brook University Health Sciences Center School of Medicine (SUNY)
Contributor Information and Disclosures

Updated: Apr 6, 2007

Workup

Laboratory Studies

  • No specific laboratory studies assist in the diagnosis of Dupuytren disease.

Imaging Studies

  • No specific imaging studies assist in the diagnosis of Dupuytren disease.

Histologic Findings

Histologic analyses of lesions resulting from Dupuytren contractures indicate physiologic characteristics of hypertrophic scar formation, including the following: myofibroblastic proliferation with increased water levels, type III collagen, chondroitin sulfate, and reducible cross-linkages. In addition, surrounding areas without clinical manifestations reveal newly formed type III collagen, reducible cross-links, and fibroblasts with myofibroblastic characteristics such as intracellular microfilaments, as well as basement lamina-like condensation. This evidence suggests that Dupuytren disease spreads by migrating along the altered collagen bundles and that clinically silent areas are also affected.

More on Dupuytren Contracture

Overview: Dupuytren Contracture
Workup: Dupuytren Contracture
Treatment: Dupuytren Contracture
Follow-up: Dupuytren Contracture
References
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References

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Further Reading

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Keywords

Dupuytren's disease, Dupuytren disease, fibromatosis, fibromatoses, Dupuytren's contractures, palmar contracture, palmar fascia

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Contributor Information and Disclosures

Author

Steve Lee, MD, Physician in Plastic, Reconstructive, and Hand Surgery, The Samra Group
Steve Lee, MD is a member of the following medical societies: American College of Surgeons and American Society of Plastic Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Michael Baytion, BS, Ohio State University College of Medicine
Disclosure: Nothing to disclose.

Mark F Hendrickson, MD, Chief, Section of Hand Surgery, Department of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation
Disclosure: Nothing to disclose.

Derek L Reinke, MD, Consulting Staff, Cary Orthopedic and Sports Medicine Specialists
Disclosure: Nothing to disclose.

Yelena Bogdan, Stony Brook University Health Sciences Center School of Medicine (SUNY)
Yelena Bogdan is a member of the following medical societies: Phi Beta Kappa
Disclosure: Nothing to disclose.

Medical Editor

Michael S Clarke, MD, Clinical Associate Professor, Department of Orthopedic Surgery, University of Missouri-Columbia School of Medicine
Michael S Clarke, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Academy of Pediatrics, American Association for Hand Surgery, American College of Surgeons, American Medical Association, Arthroscopy Association of North America, Clinical Orthopaedic Society, Mid-Central States Orthopaedic Society, and Missouri State Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Michael Yaszemski, MD, PhD, Associate Professor, Departments of Orthopedic Surgery and Bioengineering, Mayo Foundation, Mayo Medical School
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD, Consulting Surgeon, Broward Hand Center, Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society
Disclosure: Nothing to disclose.

 
 
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