eMedicine Specialties > Orthopedic Surgery > Hand & Upper Extremity

Dupuytren Contracture: Follow-up

Author: Steve Lee, MD, Physician in Plastic, Reconstructive, and Hand Surgery, The Samra Group
Coauthor(s): Michael Baytion, BS, Ohio State University College of Medicine; Mark F Hendrickson, MD, Chief, Section of Hand Surgery, Department of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation; Derek L Reinke, MD, Consulting Staff, Cary Orthopedic and Sports Medicine Specialists; Yelena Bogdan, Stony Brook University Health Sciences Center School of Medicine (SUNY)
Contributor Information and Disclosures

Updated: Apr 6, 2007

Future and Controversies

Dupuytren disease has been researched extensively since its initial discovery in the 16th and 17th centuries. However, debate regarding the exact cause of the disease continues. Future nonoperative therapies may include percutaneous needle fasciotomy, skeletal traction, therapy with calcium channel blockers, and treatment with gamma-interferon. The last of these treatments shows the most promise. Until any of these treatments is proven to be therapeutic, surgery is still the only option for a cure.

 


More on Dupuytren Contracture

Overview: Dupuytren Contracture
Workup: Dupuytren Contracture
Treatment: Dupuytren Contracture
Follow-up: Dupuytren Contracture
References
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References

  1. Al-Qattan MM. Factors in the pathogenesis of Dupuytren's contracture. J Hand Surg [Am]. Nov 2006;31(9):1527-34. [Medline].

  2. Alioto RJ, Rosier RN, Burton RI, Puzas JE. Comparative effects of growth factors on fibroblasts of Dupuytren's tissue and normal palmar fascia. J Hand Surg [Am]. May 1994;19(3):442-52. [Medline].

  3. Augoff K, Ratajczak K, Gosk J, et al. Gelatinase A activity in Dupuytren's disease. J Hand Surg [Am]. Dec 2006;31(10):1635-9. [Medline].

  4. Badalamente MA, Hurst LC. The biochemistry of Dupuytren's disease. Hand Clin. Feb 1999;15(1):35-42, v-vi. [Medline].

  5. Badois FJ, Lermusiaux JL, Masse C, Kuntz D. [Non-surgical treatment of Dupuytren disease using needle fasciotomy] [French]. Rev Rhum Ed Fr. Nov 30 1993;60(11):808-13. [Medline].

  6. Bower M, Nelson M, Gazzard BG. Dupuytren's contractures in patients infected with HIV. BMJ. Jan 20 1990;300(6718):164-5. [Medline]. [Full Text].

  7. Bradlow A, Mowat AG. Dupuytren's contracture and alcohol. Ann Rheum Dis. Apr 1986;45(4):304-7. [Medline]. [Full Text].

  8. Burge P, Hoy G, Regan P, Milne R. Smoking, alcohol and the risk of Dupuytren's contracture. J Bone Joint Surg Br. Mar 1997;79(2):206-10. [Medline]. [Full Text].

  9. Critchley EM, Vakil SD, Hayward HW, Owen VM. Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. J Neurol Neurosurg Psychiatry. May 1976;39(5):498-503. [Medline].

  10. Gabbiani G, Majno G. Dupuytren's contracture: fibroblast contraction? An ultrastructural study. Am J Pathol. Jan 1972;66(1):131-46. [Medline].

  11. Hueston JT. The incidence of Dupuytren's contracture. Med J Aust. 1960;2:999-1002.

  12. Hueston JT. Diagnosis and indications for surgical treatment [Comment]. Hand Clin. Nov 1991;7(4):643.

  13. Hueston JT. State of the art: the management of recurrent Dupuytren's disease. Eur Med Bib. 1991;1:4-7.

  14. Hueston JT. Dermofasciectomy for Dupuytren's disease. Bull Hosp Jt Dis Orthop Inst. 1984;44(2):224-32. [Medline].

  15. Ling RS. The genetic factor in dupuytren's disease. J Bone Joint Surg Br. Nov 1963;45:709-18. [Medline].

  16. McCash CR. The open palm technique in Dupuytren's contracture. Br J Plast Surg. Jul 1964;17:271-80. [Medline].

  17. McFarlane RM. Dupuytren's disease. In: Georgiade GS, Riefkohl R, Levin LS, eds. Georgiade Plastic, Maxillofacial and Reconstructive Surgery. 3rd ed. Baltimore, Md:. Lippincott, Williams & Wilkins;1996: 1038-45.

  18. McFarlane RM, McGrouther DM. Complications and their management. In: McFarlane RM, McGrouther DA, Flint MH, eds. Dupuytren's Disease: Biology and Treatment. Edinburgh, Scotland: Churchill Livingstone;1990:377-82.

  19. McFarlane RM. Dupuytren's disease. In: McCarthy JG, May JW, Littler JW, eds. Plastic Surgery. Philadelphia, Pa: WB Saunders;1990:5053-8.

  20. McGrouther DA. Dupuytren's contracture. In: Green DP, Hotchkiss RN, Pederson WC. Green's Operative Hand Surgery. 4th ed. New York, NY: Churchill Livingstone;1999:565.

  21. Messina A, Messina J. The continuous elongation treatment by the TEC device for severe Dupuytren's contracture of the fingers. Plast Reconstr Surg. Jul 1993;92(1):84-90. [Medline].

  22. Mullins PA. Postsurgical rehabilitation of Dupuytren's disease. Hand Clin. Feb 1999;15(1):167-74, viii. [Medline].

  23. Murrell GA, Francis MJ. Cyclooxygenase and oxygen free radical-stimulated fibroblast proliferation. Biochem Soc Trans. 1989;17:482-3.

  24. Murrell GA, Francis MJ, Bromley L. Modulation of fibroblast proliferation by oxygen free radicals. Biochem J. Feb 1 1990;265(3):659-65. [Medline]. [Full Text].

  25. Neumuller J, Menzel J, Millesi H. Prevalence of HLA-DR3 and autoantibodies to connective tissue components in Dupuytren's contracture. Clin Immunol Immunopathol. May 1994;71(2):142-8. [Medline].

  26. Noble J, Heathcote JG, Cohen H. Diabetes mellitus in the aetiology of Dupuytren's disease. J Bone Joint Surg Br. May 1984;66(3):322-5. [Medline]. [Full Text].

  27. Pittet B, Rubbia-Brandt L, Desmouliere A, et al. Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study. Plast Reconstr Surg. May 1994;93(6):1224-35. [Medline].

  28. Ross DC. Epidemiology of Dupuytren's disease. Hand Clin. Feb 1999;15(1):53-62, vi. [Medline].

  29. Saar JD, Grothaus PC. Dupuytren's disease: an overview. Plast Reconstr Surg. Jul 2000;106(1):125-34; quiz 135-6. [Medline].

  30. Schultz RJ, Tomasek JJ. Cellular structure and interconnections. In: McFarlane RM, McGrouther DA, Flint MH, eds. Dupuytren's disease: Biology and Treatment. Edinburgh, Scotland: Churchill Livingstone;1990.

  31. Seyhan H, Kopp J, Schultze-Mosgau S, Horch RE. Increased metabolic activity of fibroblasts derived from cords compared with nodule fibroblasts sampling from patients with Dupuytren's contracture. Plast Reconstr Surg. Apr 2006;117(4):1248-52. [Medline].

  32. Smith AC. Diagnosis and indications for surgical treatment. Hand Clin. Nov 1991;7(4):635-42; discussion 643. [Medline].

  33. Smith P, Breed C. Central slip attenuation in Dupuytren's contracture: a cause of persistent flexion of the proximal interphalangeal joint. J Hand Surg [Am]. Sep 1994;19(5):840-3. [Medline].

  34. Verheyden CN. The history of Dupuytren's contracture. Clin Plast Surg. Oct 1983;10(4):619-25. [Medline].

  35. Wallace AF. Dupuytren's contracture in women. Br J Plast Surg. Oct 1965;18(4):385-6. [Medline].

  36. Watson HK, Paul H Jr. Pathologic anatomy. Hand Clin. Nov 1991;7(4):661-8. [Medline].

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Further Reading

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Keywords

Dupuytren's disease, Dupuytren disease, fibromatosis, fibromatoses, Dupuytren's contractures, palmar contracture, palmar fascia

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Contributor Information and Disclosures

Author

Steve Lee, MD, Physician in Plastic, Reconstructive, and Hand Surgery, The Samra Group
Steve Lee, MD is a member of the following medical societies: American College of Surgeons and American Society of Plastic Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Michael Baytion, BS, Ohio State University College of Medicine
Disclosure: Nothing to disclose.

Mark F Hendrickson, MD, Chief, Section of Hand Surgery, Department of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation
Disclosure: Nothing to disclose.

Derek L Reinke, MD, Consulting Staff, Cary Orthopedic and Sports Medicine Specialists
Disclosure: Nothing to disclose.

Yelena Bogdan, Stony Brook University Health Sciences Center School of Medicine (SUNY)
Yelena Bogdan is a member of the following medical societies: Phi Beta Kappa
Disclosure: Nothing to disclose.

Medical Editor

Michael S Clarke, MD, Clinical Associate Professor, Department of Orthopedic Surgery, University of Missouri-Columbia School of Medicine
Michael S Clarke, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Academy of Pediatrics, American Association for Hand Surgery, American College of Surgeons, American Medical Association, Arthroscopy Association of North America, Clinical Orthopaedic Society, Mid-Central States Orthopaedic Society, and Missouri State Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Michael Yaszemski, MD, PhD, Associate Professor, Departments of Orthopedic Surgery and Bioengineering, Mayo Foundation, Mayo Medical School
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD, Consulting Surgeon, Broward Hand Center, Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society
Disclosure: Nothing to disclose.

 
 
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