eMedicine Specialties > Orthopedic Surgery > Hand & Upper Extremity

Distal Humerus Fractures

Author: Edward Yian, MD, Consulting Staff, Department of Orthopedic Surgery, Southern California Permanente Group Orange County
Coauthor(s): Madhav Karunakar, MD, Consulting Surgeon, Section of Orthopedic Surgery, Department of Surgery, University of Michigan Medical Center
Contributor Information and Disclosures

Updated: Jul 26, 2007

Introduction

The elbow joint coordinates movements of the upper extremity, facilitating the execution of activities of daily living in areas such as hygiene, dressing, and cooking. When the distal humerus is injured, elbow joint function can be impaired. The goal of open reduction and internal fixation is restoration of normal anatomy. Distal humerus fractures continue to provide challenging reconstructive problems for the orthopedic surgeon.

For excellent patient education resources, visit eMedicine's Breaks, Fractures, and Dislocations Center. Also, see eMedicine's patient education articles Broken Arm and Broken Elbow.

History of the Procedure

Many physicians once believed that optimal recovery for complex distal humerus fractures could be achieved through conservative treatment. In 1937, Eastwood described the "bag of bones" technique, which involved compressive manipulation of the distal fragments with collar-and-cuff support and the elbow in flexion.1 After a 2-week period in which the elbow was immobilized at 120 º of flexion, extension was gradually increased. Better outcomes were observed in elderly patients, with ulnohumeral motion averaging 116 º after 2.5 years of follow-up. However, Evans observed that despite the functional range of motion, the final outcome often was a weak and unstable elbow.2

Regarding operative treatment, Watson-Jones commented that even with a perfect anatomic reduction, "the resulting joint movement is always less satisfactory than after less accurate reduction obtainable with external means." As late as 1969, Riseborough and Radin warned of the limitations of operative intervention for distal humerus fractures.3

Numerous advocates of conservative treatment have described less extensive operative techniques for these fractures. In 1943, Watson-Jones recommended closed treatment or a limited open reduction with Kirschner wires (K-wires) based on poor outcomes with intra-articular involvement. Percutaneous pinning of transcolumnar and supracondylar fractures in elderly, relatively inactive patients continues to be a viable treatment option.

Lambotte, in the first decade of the 20th century, was one of the first to describe operative techniques for stable osteosynthesis of the distal humerus.4 In the early 1960s, with the formation of the Swiss Arbeitsgemeinschaft f ü r Osteosynthesefragen – Association for the Study of Internal Fixation (AO-ASIF) group, formal techniques to achieve anatomic reduction with stable fixation began to evolve. Consequently, open reduction and internal fixation of displaced distal humerus fractures has become the standard of care for most patients. Even today, the operative technique continues to evolve.

Problem

Much of the difficulty encountered in treating distal humerus fractures lies in the complex anatomy of the elbow joint. The highly constrained nature of the elbow joint causes it to absorb energy following direct trauma. Consequently, articular comminution may occur. The distal humerus has a narrow supracondylar isthmus with a sparsity of adequate subchondral metaphyseal supporting bone, especially within the olecranon fossa. The osteopenia observed in elderly patients adds to the complexity. Hastings and Engles have described a "spill over effect," in which inadequate restoration of a singularly injured joint can lead to abnormal wear and degenerative changes in an adjacent articulation. This effect can apply to the elbow.

Frequency

The incidence of fractures of the elbow joint is small compared to that of fractures of other bones. Elbow joint fractures have been estimated to make up 4.3% of all fractures. Typically occurring following high-energy injury, these fractures can lead to significant functional impairment. Distal humerus fractures most commonly involve both the medial and lateral columns. Single condylar fractures make up approximately 5% of distal humerus fractures. Epicondylar and coronal shear fractures of the articular surface are less commonly observed. In the pediatric population, 80% of all elbow fractures occur in the supracondylar region. The injury typically occurs in young boys aged 5-10 years.

Etiology

Most distal humerus fractures can be classified into 2 etiologic groups: those resulting from a high-energy mechanism, such as a motor vehicle accident (MVA), and those resulting from a low-energy injury, such as a fall while walking.

Presentation

A thorough patient history must be taken in the initial evaluation of these patients. Medical history, surgical history (especially pertaining to the injured extremity), medication use, nonmedication drug use, occupation, and smoking history should be ascertained. In an elderly patient, the reason for the fall must be investigated.

The mechanism of injury also can help to identify other associated bony or ligamentous injuries. Questions regarding the speed of the MVA or the height from which a fall occurred and the position of the arm at impact should be asked.

Understanding the premorbid condition of the patient's injured extremity also is important, as is ascertaining any preexisting limitations, such as degenerative or traumatic arthritis, instability, stiffness, or neurologic abnormalities (acute or chronic), that may affect treatment.

With high-energy injuries, associated injuries to the head, chest, abdomen, spine, or pelvis must be excluded. Standard screening radiographs, including radiographs of the pelvis, spine, and chest, are obtained.

Physical examination of the patient should include examination of the injured extremity and a thorough primary and secondary survey to determine if any associated injuries are present. A complete examination of the neurovascular status of the extremity should be conducted. An accurate assessment should be made of the sensory and motor contributions of the median (including the anterior interosseous), ulnar, and radial (including the posterior interosseous) nerves, as well as the medial and lateral antebrachial cutaneous nerves. The brachial artery and median nerves lie anterior to the elbow joint and are at risk for disruption. The distal pulses should be palpated and the capillary refills should be assessed, with comparisons made to the contralateral upper extremity. If questions regarding vascular status arise, duplex Doppler studies or angiography should be performed.

Inspection and palpation also should be part of the examination. Open wounds communicating with the joint are common with high-energy injuries. These wounds should initially be treated with antibiotics and tetanus prophylaxis. A povidone-iodine dressing should be placed over the wound to prevent further wound colonization and exposure. The skin should be examined for bruising, ecchymosis, or lacerations, with these findings taken into consideration, especially if operative intervention is to be initiated. Bruising, ecchymosis, or lacerations may represent significant ligamentous damage and resultant instability. A well-padded, well-molded splint with the elbow in slight flexion and neutral rotation provides stability and pain relief until definitive treatment is possible. The splint should be applied with a nonconstrictive dressing. Signs of compartment syndrome of the forearm or upper arm also should be clinically investigated.

Indications

The decision to offer operative intervention for distal humerus fractures is based on many factors, including fracture type, intra-articular involvement, fragment displacement, bone quality, joint stability, and soft-tissue quality and coverage. In addition, individual factors, such as patient age, overall health condition, functional extremity demands, and patient compliance, are all considered. Preoperatively, patients must understand outcome expectations and the importance of rehabilitation.

Conditions in which operative intervention is supported include intra-articular fragment displacement, physeal displacement, supracondylar comminution and displacement, open fractures, floating elbow patterns, neurovascular injury, compartment syndrome, and multiple traumatic injuries.

Primary goals for operative intervention are to restore articular congruity and elbow stability. Another goal is to decrease the possibility of posttraumatic arthritis and elbow stiffness.

Relevant Anatomy

The difficulty in treating complex distal humerus fractures lies in the unique and specific anatomy of the distal humerus that allows it to articulate freely with the radius and ulna. The elbow is a trochoginglymoid joint; it has the capacity to flex and extend within the sagittal plane and also to rotate around a single axis. In fact, the elbow joint consists of 3 different articulations: the radiocapitellar, olecranon-trochlear, and proximal radioulnar joints. Motion within the sagittal plane occurs at the ulnohumeral articulation within the semilunar notch.

The distal humerus resembles a triangle, with the medial and lateral columns making up the sides and the trochlea forming the base (270° arc). The diaphyseal cortical cylindrical shape of the distal humerus splays out into a narrow isthmus to form the medial and lateral triangular columns. These columns are separated by a very thin layer of bone that posteriorly makes up the olecranon fossa and anteriorly composes the coronoid fossa. The lateral column ends distally in the capitellum. The articular surface of the capitellum represents the anterior surface of the inferior lateral column, with a 180° arc. The medial column is entirely nonarticular, with the ulnar nerve lying directly inferior in the cubital tunnel.

Reconstruction of the premorbid anatomy of the trochlea is crucial to restoration of motion and stability. The lateral column lies in approximately 20° of valgus relative to the humeral shaft. The medial column is aligned at a 40° angle to the shaft and ends in the trochlea. The capitellum is angulated 30-40° anteriorly, while the trochlea is angulated 25° anteriorly.

The ulnohumeral articulation is slightly asymmetric. The trochlea is larger in diameter medially than laterally, and this explains the normal carrying angle of the arm as it is extended. The trochlea ends more distally than the capitellum in the coronal plane, leading to a valgus position of the elbow when the arm is fully extended. When the elbow is flexed, the capitellum is projected further anteriorly, resulting in a varus posture. It is important to remember that the distal humeral articular surface is positioned at the normal carrying angle of 11-17° of valgus angulation. Most distal humerus intra-articular fractures split through the trochlear waist, causing comminution and often leading to narrowing of the trochlea after internal fixation. In addition, the condyles are rotated 3-8° internally and positioned in approximately 6° of valgus. Often, the olecranon blocks adequate visualization of the trochlea and olecranon fossa, limiting evaluation of fracture reduction.

In the pediatric population, during the first 6 months, the distal ossification border is distinct and symmetric. The ossification center of the lateral condyle appears in infants around age 1 year. The medial epicondyle appears in children aged 5 years at the medial metaphyseal region. The trochlea ossifies in children aged 9 years. The lateral epicondyle begins to form and fuse with the lateral condyle in children aged 10 years. Before the end of growth, the capitellum, lateral epicondyle, and trochlea fuse to form the epiphysis. However, the medial epicondyle is usually the last to fuse, in adolescents aged 14-17 years.

The blood supply around the elbow is primarily fed by anastomotic vessels from the brachial artery. Most vessels supplying the lateral condyle enter posteriorly and course into the ossific nucleus. They feed into the lateral portion of the trochlea.

Contraindications

Contraindications to operative intervention for distal humerus fractures are patient specific. Factors that should be considered include the patient's age, overall health condition, functional demands and expectations, and the overlying soft-tissue quality and bone quality. Finally, the surgeon must be able to make an honest evaluation of his or her ability to successfully perform open reduction and internal fixation of the fracture pattern.

More on Distal Humerus Fractures

Overview: Distal Humerus Fractures
Workup: Distal Humerus Fractures
Treatment: Distal Humerus Fractures
Follow-up: Distal Humerus Fractures
Multimedia: Distal Humerus Fractures
References

References

  1. Eastwood WJ. The T-shaped fracture of the lower end of the humerus. J Bone Joint Surg. 1937;19:364-9.

  2. Evans EM. Supracondylar-Y fractures of the humerus. J Bone Joint Surg Br. Aug 1953;35-B(3):371-5. [Medline].

  3. Riseborough EJ, Radin EL. Intercondylar T fractures of the humerus in the adult. A comparison of operative and non-operative treatment in twenty-nine cases. J Bone Joint Surg Am. Jan 1969;51(1):130-41. [Medline].

  4. Lambotte A. Chirurgie operatoire des fractures. Paris: Masson et Cie; 1913.

  5. Doornberg J, Lindenhovius A, Kloen P, et al. Two and three-dimensional computed tomography for the classification and management of distal humeral fractures. Evaluation of reliability and diagnostic accuracy. J Bone Joint Surg Am. Aug 2006;88(8):1795-801. [Medline].

  6. Skaggs DL, Mirzayan R. The posterior fat pad sign in association with occult fracture of the elbow in children. J Bone Joint Surg Am. Oct 1999;81(10):1429-33. [Medline].

  7. Vocke-Hell AK, von Laer L, Slongo T, et al. Secondary radial head dislocation and dysplasia of the lateral condyle after elbow trauma in children. J Pediatr Orthop. May-Jun 2001;21(3):319-23. [Medline].

  8. Mehne DK, Jupiter JB. Fractures of the distal humerus. In: Browner BD, Jupiter JB, Levine AM, et al, eds. Skeletal Trauma. vol 2. Philadelphia, Pa: WB Saunders Co; 1992:1146.

  9. Mehne DK, Matta J. Bicolumn fractures of the adult humerus. Paper presented at: 53rd Annual Meeting of the AAOS; 1986; New Orleans, LA.

  10. Kuhn JE, Louis DS, Loder RT. Divergent single-column fractures of the distal part of the humerus. J Bone Joint Surg Am. Apr 1995;77(4):538-42. [Medline].

  11. Skaggs DL, Hale JM, Bassett J. Operative treatment of supracondylar fractures of the humerus in children. The consequences of pin placement. J Bone Joint Surg Am. May 2001;83-A(5):735-40. [Medline].

  12. DeLee JC, Wilkins KE, Rogers LF, et al. Fracture-separation of the distal humeral epiphysis. J Bone Joint Surg Am. Jan 1980;62(1):46-51. [Medline].

  13. Pirker ME, Weinberg AM, Höllwarth ME, et al. Subsequent displacement of initially nondisplaced and minimally displaced fractures of the lateral humeral condyle in children. J Trauma. June 2005;58(6):1202-7. [Medline].

  14. Mehlman CT, Strub WM, Roy DR. The effect of surgical timing on the perioperative complications of treatment of supracondylar humeral fractures in children. J Bone Joint Surg Am. Mar 2001;83-A(3):323-7. [Medline].

  15. Laporte C, Thiongo M, Jegou D. Posteromedial approach to the distal humerus for fracture fixation. Acta Orthop Belg. Aug 2006;72(4):395-9. [Medline].

  16. Bryan RS, Morrey BF. Extensive posterior exposure of the elbow. A triceps-sparing approach. Clin Orthop. Jun 1982;(166):188-92. [Medline].

  17. Livani B, Belangero WD, Castro de Medeiros R. Fractures of the distal third of the humerus with palsy of the radial nerve: management using minimally-invasive percutaneous plate osteosynthesis. J Bone Joint Surg Br. Dec 2006;88(12):1625-8. [Medline].

  18. Schemitsch EH, Tencer AF, Henley MB. Biomechanical evaluation of methods of internal fixation of the distal humerus. J Orthop Trauma. Dec 1994;8(6):468-75. [Medline].

  19. Jupiter JB, Mehne DK. Fractures of the distal humerus. Orthopedics. Jul 1992;15(7):825-33. [Medline].

  20. Jupiter JB, Goodman LJ. The management of complex distal humerus nonunion in the elderly by elbow capsulectomy, triple plating, and ulnar nerve neurolysis. J Shoulder Elbow Surg. 1992;1:37-42.

  21. Lee SS, Mahar AT, Miesen D, et al. Displaced pediatric supracondylar humerus fractures: biomechanical analysis of percutaneous pinning techniques. J Pediatr Orthop. Jul-Aug 2002;22(4):440-3. [Medline].

  22. Mansat P, Morrey BF. The column procedure: a limited lateral approach for extrinsic contracture of the elbow. J Bone Joint Surg Am. Nov 1998;80(11):1603-15. [Medline].

  23. Hastings H 2nd, Graham TJ. The classification and treatment of heterotopic ossification about the elbow and forearm. Hand Clin. Aug 1994;10(3):417-37. [Medline].

  24. Hall J, Schemitsch EH, McKee MD. Use of a hinged external fixator for elbow instability after severe distal humeral fracture. J Orthop Trauma. Aug 2000;14(6):442-5. [Medline].

  25. Dormans JP, Squillante R, Sharf H. Acute neurovascular complications with supracondylar humerus fractures in children. J Hand Surg [Am]. Jan 1995;20(1):1-4. [Medline].

  26. Cramer KE, Green NE, Devito DP. Incidence of anterior interosseous nerve palsy in supracondylar humerus fractures in children. J Pediatr Orthop. Jul-Aug 1993;13(4):502-5. [Medline].

  27. Oh CW, Park BC, Ihn JC, et al. Fracture separation of the distal humeral epiphysis in children younger than three years old. J Pediatr Orthop. Mar-Apr 2000;20(2):173-6. [Medline].

  28. Henley MB. Intra-articular distal humeral fractures in adults. Orthop Clin North Am. Jan 1987;18(1):11-23. [Medline].

  29. Wang KC, Shih HN, Hsu KY, et al. Intercondylar fractures of the distal humerus: routine anterior subcutaneous transposition of the ulnar nerve in a posterior operative approach. J Trauma. Jun 1994;36(6):770-3. [Medline].

  30. McKee MD, Wilson TL, Winston L. Functional outcome following surgical treatment of intra-articular distal humeral fractures through a posterior approach. J Bone Joint Surg Am. Dec 2000;82-A(12):1701-7. [Medline].

  31. Aitken GK, Rorabeck CH. Distal humeral fractures in the adult. Clin Orthop. Jun 1986;(207):191-7. [Medline].

  32. Breen T, Gelberman RH, Leffert R, et al. Massive allograft replacement of hemiarticular traumatic defects of the elbow. J Hand Surg [Am]. Nov 1988;13(6):900-7. [Medline].

  33. Brown RF, Morgan RG. Intercondylar T-shaped fractures of the humerus. Results in ten cases treated by early mobilisation. J Bone Joint Surg Br. Aug 1971;53(3):425-8. [Medline][Full Text].

  34. Cobb TK, Morrey BF. Total elbow arthroplasty as primary treatment for distal humeral fractures in elderly patients. J Bone Joint Surg Am. Jun 1997;79(6):826-32. [Medline].

  35. Cohen MS, Hastings H 2nd. Post-traumatic contracture of the elbow. Operative release using a lateral collateral ligament sparing approach. J Bone Joint Surg Br. Sep 1998;80(5):805-12. [Medline].

  36. Greenspan A, Norman A, Rosen H. Radial head-capitellum view in elbow trauma: clinical application and radiographic-anatomic correlation. AJR Am J Roentgenol. Aug 1984;143(2):355-9. [Medline].

  37. Hastings H 2nd, Engles DR. Fixation of complex elbow fractures, part I. General overview and distal humerus fractures. Hand Clin. Nov 1997;13(4):703-19. [Medline].

  38. Heim D, Regazzoni P, Perren SM. Current use of external fixation in open fractures: external fixator - what next?. Injury. 1993;23:S1-S35.

  39. Helfet DL, Hotchkiss RN. Internal fixation of the distal humerus: a biomechanical comparison of methods. J Orthop Trauma. 1990;4(3):260-4. [Medline].

  40. Helfet DL, Schmeling GJ. Bicondylar intraarticular fractures of the distal humerus in adults. Clin Orthop. Jul 1993;(292):26-36. [Medline].

  41. Heyd R, Strassmann G, Schopohl B, et al. Radiation therapy for the prevention of heterotopic ossification at the elbow. J Bone Joint Surg Br. Apr 2001;83(3):332-4. [Medline].

  42. Ilahi OA, Strausser DW, Gabel GT. Post-traumatic heterotopic ossification about the elbow. Orthopedics. Mar 1998;21(3):265-8. [Medline].

  43. Kirk P, Goulet JA, Freiberg A. A biomechanical evaluation of fixation methods for fractures of the distal humerus. Orthop Trans. 1990;14:674.

  44. Kuntz DG Jr, Baratz ME. Fractures of the elbow. Orthop Clin North Am. Jan 1999;30(1):37-61. [Medline].

  45. Mast J, Jakob R, Ganz R. Planning and Reduction Technique in Fracture Surgery. Berlin: Springer-Verlag; 1-10.

  46. McKee M, Jupiter J, Toh CL, et al. Reconstruction after malunion and nonunion of intra-articular fractures of the distal humerus. Methods and results in 13 adults. J Bone Joint Surg Br. Jul 1994;76(4):614-21. [Medline][Full Text].

  47. McKee MD, Jupiter JB, Bamberger HB. Coronal shear fractures of the distal end of the humerus. J Bone Joint Surg Am. Jan 1996;78(1):49-54. [Medline].

  48. Milch H. Fractures and fracture dislocations of the humeral condyles. J Trauma. Sep 1964;15:592-607. [Medline].

  49. Morrey BF, Adams RA. Semiconstrained elbow replacement for distal humeral nonunion. J Bone Joint Surg Br. Jan 1995;77(1):67-72. [Medline][Full Text].

  50. Muller ME, Allgower M, Schneider R, et al. 3rd ed. Manual of Internal Fixation: Techniques Recommended by the AO-ASIF Group. Berlin: Springer-Verlag; 1991:411-52.

  51. O'Driscoll SW. The triceps-reflecting anconeus pedicle (TRAP) approach for distal humeral fractures and nonunions. Orthop Clin North Am. Jan 2000;31(1):91-101. [Medline].

  52. Ring D, Jupiter JB. Complex fractures of the distal humerus and their complications. J Shoulder Elbow Surg. Jan-Feb 1999;8(1):85-97. [Medline].

  53. Stover MD, Wilber JH. Nonunions of the distal humerus: open reduction and internal fixation. Semin Arthroplasty. 2001;12:127-34.

  54. Van Gorder GW. Surgical approach in supracondylar fractures of the humerus requiring open reduction. J Bone Joint Surg. 1940;22:278.

  55. Viola B, Hastings H. Ectopic ossification about the elbow. Clin Orthop Rel Res. 2000;370:62-85.

  56. Watson-Jones R. Fractures and Joint Injuries. 4th ed. Baltimore, Md: Williams & Wilkins; 1955:534.

  57. Webb LX. Distal humeral fractures in adults. J Am Acad Orthop Surg. Nov 1996;4(6):336-44. [Medline].

  58. Wilkins KE, Beaty JH, Chambers HG. Fractures and dislocations of the elbow region. In: Rockwood CA Jr, Wilkins KE, Beaty JH, eds. Fractures in Children. 4th ed. Philadelphia, Pa: Lippincott-Raven; 1996:759.

Further Reading

Keywords

elbow fractures, supracondylar humerus fractures, elbow injuries, distal humerus injuries, elbow joint fractures, single condylar fractures, epicondylar fractures, coronal shear fractures of the articular surface, distal humeral fractures, distal humeral injuries

Contributor Information and Disclosures

Author

Edward Yian, MD, Consulting Staff, Department of Orthopedic Surgery, Southern California Permanente Group Orange County
Edward Yian, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Madhav Karunakar, MD, Consulting Surgeon, Section of Orthopedic Surgery, Department of Surgery, University of Michigan Medical Center
Madhav Karunakar, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons and AO Foundation
Disclosure: Nothing to disclose.

Medical Editor

Peter M Murray, MD, Associate Professor of Orthopedic Surgery, Mayo Clinic College of Medicine; Director of Education, Mayo Foundation for Medical Education and Research; Consultant, Department of Orthopedic Surgery, Mayo Clinic, Jacksonville; Consulting Staff, Nemours Children's Clinic and Wolfson's Children's Hospital
Peter M Murray, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association for Hand Surgery, American Orthopaedic Association, American Society for Surgery of the Hand, American Society of Reconstructive Microsurgery, Florida Medical Association, Orthopaedic Research Society, and Society of Military Orthopedic Surgeons
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Thomas R Hunt III, MD, John D Sherrill Professor of Surgery, Director, Division of Orthopedic Surgery, Surgeon in Chief, UAB Upper Extremity Fellowship, UAB Highlands Hospital, University of Alabama at Birmingham School of Medicine
Thomas R Hunt III, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association for Hand Surgery, American Orthopaedic Association, American Orthopaedic Society for Sports Medicine, American Society for Surgery of the Hand, AO Foundation, and Mid-America Orthopaedic Association
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Harris Gellman, MD, Consulting Surgeon, Broward Hand Center, Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, and Arkansas Medical Society
Disclosure: Nothing to disclose.

 
 
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