eMedicine Specialties > Endocrinology > Metabolic Bone Disease
Osteopetrosis: Follow-up
Updated: Oct 13, 2009
Follow-up
Deterrence/Prevention
- Counsel patients on appropriate lifestyle modifications to prevent fractures.
- Provide genetic counseling to patients to allow appropriate family planning.
Complications
- Infantile osteopetrosis
- Bone marrow failure may occur, resulting in severe anemia, bleeding, or infections.
- Growth retardation and failure to thrive can occur.
Prognosis
- Infantile osteopetrosis
- If untreated, infantile osteopetrosis usually results in death by the first decade of life due to severe anemia, bleeding, or infections.
- Patients fail to thrive, have growth retardation, and suffer increased morbidity.
- The prognosis of some patients can markedly change after BMT.
- Adult osteopetrosis: Patients have good long-term survival rates.
Miscellaneous
Medicolegal Pitfalls
- In the differential diagnosis, include conditions that can result in diffuse osteosclerosis.
- Such conditions may include congenital disorders (eg, pyknodysostosis, hypoparathyroidism, pseudohypoparathyroidism), chemical poisoning (eg, fluoride, lead, beryllium), malignancies (leukemia, myeloproliferative diseases), and sickle cell disease.
More on Osteopetrosis |
| Overview: Osteopetrosis |
| Differential Diagnoses & Workup: Osteopetrosis |
| Treatment & Medication: Osteopetrosis |
Follow-up: Osteopetrosis |
| References |
| Further Reading |
| « Previous Page |
References
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Further Reading
Clinical guidelines:
Evaluating infants and young children with multiple fractures. American Academy of Pediatrics - Medical Specialty Society. 2006 Sep. 5 pages. NGC:005253
Clinical trials:
Allogeneic Transplantation For Severe Osteopetrosis
rhPTH Therapy for Low Turnover Bone Fragility
Keywords
osteopetrosis, osteoclast, osteoblast osteoclast, osteosclerosis, osteosclerotic, Albers-Schönberg disease, marble bone disease, osteoclastic bone resorption, infantile osteopetrosis, infantile malignant osteopetrosis, adult osteopetrosis, benign osteopetrosis
Follow-up: Osteopetrosis