Type III Polyglandular Autoimmune Syndrome Medication

  • Author: KoKo Aung, MD, MPH, FACP; Chief Editor: George T Griffing, MD   more...
 
Updated: Jan 3, 2012
 

Medication Summary

The goals of pharmacotherapy are to correct hormone deficiencies, prevent complications, and reduce morbidity.

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Thyroid hormones

Class Summary

These agents are administered for replacement of thyroid hormone in hypothyroidism.

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Levothyroxine (Synthroid, Levoxyl, Levothroid)

 

Rapidly inhibits the release of thyroid hormones via a direct effect on the thyroid gland and inhibits the synthesis of thyroid hormones. Iodide also appears to attenuate the cAMP-mediated effects of thyrotropin. In active form, influences growth and maturation of tissues. Involved in normal growth, metabolism, and development.

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Antidiabetic agents

Class Summary

Insulin is used for replacement therapy in IMD.

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Insulin regular human (Novolin, Humulin, Lente Iletin, Lente L, NPH Insulin)

 

Stimulates proper use of glucose by cells and reduces blood sugar levels. Multiple forms of insulin with different time constants for activity, from very rapid onset and activity to very long sustained activity, can be used to provide glucose control.

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Vitamins

Class Summary

Vitamins are essential for normal DNA synthesis and for replacement therapy with vitamin B-12 in PA.

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Cyanocobalamin (Nascobal, Crystamine, Crysti 1000, Cyomin)

 

Deoxyadenosylcobalamin and hydroxocobalamin are active forms of vitamin B-12 in humans. Vitamin B-12 synthesized by microbes but not humans or plants.

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Contributor Information and Disclosures
Author

KoKo Aung, MD, MPH, FACP  Associate Professor, Department of Medicine, University of Texas Health Science Center at San Antonio; Adjunct Associate Professor of Public Health, University of Texas School of Public Health

KoKo Aung, MD, MPH, FACP is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS  Professor of Medicine (Endocrinology, Adj), Johns Hopkins School of Medicine; Affiliate Research Professor, Bioinformatics and Computational Biology Program, School of Computational Sciences, George Mason University; Principal, C/A Informatics, LLC

Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Endocrinology, American College of Nutrition, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Medical Informatics Association, American Society for Bone and Mineral Research, Endocrine Society, and International Society for Clinical Densitometry

Disclosure: Nothing to disclose.

Mark Cooper, MBBS, PhD, FRACP  Head, Diabetes & Metabolism Division, Baker Heart Research Institute, Professor of Medicine, Monash University

Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD  Professor of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Medical Practice Executives, American College of Physician Executives, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical Research, Endocrine Society, International Society for Clinical Densitometry, and Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Additional Contributors

The editors wish to thank Magdi Salmon, MD, for his previous contributions to this article.

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