Outcome and Prognosis
The success rate in patients not treated by arthroplasty in stage 0 or I approaches 90% in some series. Once femoral head collapse occurs, these treatments offer limited benefit. Procedures such as the trapdoor procedure potentially may improve results in stage II and III, but presently, total hip replacement remains the treatment of choice once collapse has occurred. If not treated, 80% of femoral heads collapse within 4 years of diagnosis. Location and extent of the necrotic lesion appear to be good indicators of collapse of the femoral head.
Future and Controversies
The natural history of atraumatic osteonecrosis is still not well understood. Different etiologies of the disease often have different clinical courses. Steroid-induced disease has the worst prognosis, and most cases progress to collapse of the femoral head. Future studies hopefully will focus on the natural history of the disease; surgical procedures of limited morbidity to prevent collapse in the early stages; and procedures for use following collapse but before development of arthritis, short of total hip replacement.
Prostheses with novel bearing surfaces (ie, metal-on-metal, ceramic-on-ceramic) are being investigated, to increase the success rate for total hip replacements in patients with osteonecrosis.
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References
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Further Reading
Related eMedicine topics
Avascular Necrosis, Femoral Head
Total Hip Replacement
Osteonecrosis, Knee
Osteonecrosis, Shoulder
Avascular Necrosis
Femoral Head Avascular Necrosis
Clinical guidelines
ACR Appropriateness Criteria® avascular necrosis of the hip. American College of Radiology - Medical Specialty Society. 1995 (revised 2005). 8 pages. NGC:004628
Clinical trials
Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head
Osteonecrosis of the Hip
Proposal For The Development Of A Well Defined Database For Patients With Oral Bisphosphonate-Related Osteonecrosis
Avascular Necrosis (AVN) Long-Term Follow-up
Keywords
hip osteonecrosis, aseptic necrosis, avascular necrosis, osteonecrosis of the femoral head, ischemic necrosis, protein C deficiency, protein S deficiency, sickle cell anemia
Follow-up: Osteonecrosis, Hip