eMedicine Specialties > Orthopedic Surgery > Knee

Tibial Shaft Fractures

Author: Brian K Konowalchuk, MD, Staff Physician, Department of Orthopedic Surgery, University of Minnesota College of Medicine
Coauthor(s): Nicholas J Wills, MD, Fellow, Twin Cities Spine Center; Brian Tollefson, MD, Flight Surgeon, United States Air Force; Marc Swiontkowski, MD, Chair, Professor, Department of Orthopedic Surgery, University of Minnesota at Minneapolis
Contributor Information and Disclosures

Updated: May 15, 2009

Introduction

An understanding of the diagnosis and treatment of tibial shaft fractures is of importance to primary care physicians and orthopedic surgeons alike. Often, the primary care provider first comes into contact with tibial shaft fractures and must make the diagnosis and early treatment decisions. High-speed lifestyles with motor vehicles, snowmobiles, and motorcycles, as well as the growing popularity of extreme sports, contribute to the increasing occurrence of tibial shaft fractures in today's society. In fact, the tibia is currently the most commonly fractured long bone in the body.

Standard anteroposterior radiograph of a tibial s...

Standard anteroposterior radiograph of a tibial shaft fracture with intramedullary nail fixation. Note the commonly associated fibular fracture that is also apparent.

Standard anteroposterior radiograph of a tibial s...

Standard anteroposterior radiograph of a tibial shaft fracture with intramedullary nail fixation. Note the commonly associated fibular fracture that is also apparent.


Radiograph demonstrating a displaced tibial shaft...

Radiograph demonstrating a displaced tibial shaft fracture with associated fibula fracture.

Radiograph demonstrating a displaced tibial shaft...

Radiograph demonstrating a displaced tibial shaft fracture with associated fibula fracture.


For excellent patient education resources, visit eMedicine's Breaks, Fractures, and Dislocations Center. Also, see eMedicine's patient education articles Broken Leg, Ankle Fracture, and Knee Dislocation.

History of the Procedure

Plating tibial shaft fractures was the treatment of choice 2-3 decades ago. Intramedullary nailing and external fixation have replaced fracture plating because they are associated with decreased technical difficulty, lower infection rates, and less damage to local soft tissues (see Treatment, Intraoperative details, below).

Problem

The tibia is the most commonly fractured long bone in the body. Tibial shaft fractures are often the result of high-speed trauma but can also be insidious in onset, such as stress fractures in active individuals. During the initial evaluation, the patient with a tibial shaft fracture should be evaluated carefully for open wounds at the fracture site, neurovascular sufficiency, and elevated compartment pressures. Abnormalities in any of these areas constitute a surgical emergency.

Frequency

The tibia is currently the most commonly fractured long bone in the body. Alho et al have reported an annual incidence of 2 tibial shaft fractures per 1000 individuals.1 The average age of patients with tibial shaft fractures is approximately 37 years, and teenage males are reported to have the highest incidence.2

Etiology

In the etiology of tibial fractures, high-speed trauma is paramount. In areas where people drive cars at high speeds and engage in activities with high potential for leg trauma (eg, skiing, soccer), the number of tibial fractures seen in the emergency department is high. While a direct blow to the tibia is the most common cause, countless other etiologies for tibial shaft fractures are encountered. Two of the most prevalent are falls or jumps from significant height and gunshot wounds to the lower leg.

Presentation

Patients with tibial shaft fractures report pain of varying degrees, but pain is usually severe. An inability to bear weight on the affected leg and a visible malformation of the leg are often present. Partial fractures may be less characteristic in presentation. The evaluating physician should always keep tibial fracture as part of the differential diagnosis after trauma, especially in a patient with an altered mental status who cannot provide a reliable history.

If the patient's symptoms stem from a stress fracture, the patient may reveal a recent change in lifestyle or an increase in physical activity. The pain is worse with weightbearing exercise and improves with rest. A classic presentation is an athlete who did not participate in conditioning work during summer vacation and presents to the physician's office 2 weeks after beginning vigorous training in a fall sport.3

Whatever the presentation, taking a complete history and performing a thorough physical examination are important. The history should include the patient's description of the events that brought him or her to the office. Important details to obtain from the patient include exactly what the patient was doing at the time of the injury, the amount of time that has passed since the injury occurred, a description of pain, any associated paresthesias or numbness, and a history of previous conditions that predispose to this injury or complicate surgery.

During the physical examination, the physician should not focus just on the leg, because concomitant injury is common with tibial fractures. After the other aspects of the examination have been addressed, the physician should specifically attempt to assess the neurovascular status of the patient's injured leg. The results of these examinations are important because their outcomes determine the emergent level of the situation and dictate which surgical specialists must be consulted. The overlying skin should also be examined, with particular care taken in assessing any open wounds or color changes that may indicate a more serious injury.

Classification and nomenclature

Classifications for fractures are useful for consistent communication between physicians. They have been used to predict probability of fracture union and, hence, as a guide for fracture treatment.4,5,6,7,8,9 The classic classification for open fractures was described by Gustilo et al, as follows10 :

  • Type I: The wound is clean and is shorter than 1 cm.
  • Type II: The wound is longer than 1 cm and does not have extensive soft tissue damage.
  • Type IIIa: This fracture type is a wound associated with extensive soft tissue damage usually larger than 10 cm with periosteal coverage. (Periosteum is the outermost layer of bone. It has a rich vascular supply and is important in bone growth and repair.) This fracture type also includes less traumatic fractures with increased chances of complications, such as gunshot wounds, farmyard injuries, and fractures requiring vascular repair.
  • Type IIIb: This type is defined as bone with periosteal stripping that must be covered; these fractures nearly always require flap coverage.
  • Type IIIc: This type of injury requires vascular repair.

The Orthopaedic Trauma Association has also adopted a system of classification for tibial shaft fracture. Their system, based on radiographic evaluation, divides fractures into 3 main categories (ie, A, B, and C).11,12 Each category is divided into 3 groups, and each group is then further divided into 3 subgroups.

  • Type A: This type encompasses unifocal fractures. The subgroups (A1, A2, and A3) are determined by the angle of the fracture. Spiral fractures make up group A1, oblique fractures are A2, and transverse fractures are classified as A3.
  • Type B: These are wedge fractures. This category is then further divided into intact spiral wedge fractures, intact bending wedge fractures, and comminuted wedge fractures. These are classified as groups B1, B2, and B3, respectively. The 3 subgroups for both type A and type B fractures are determined by the extent of fibular injury and location of fracture with respect to the tibia.
  • Type C: Complex fractures are classified as type C. C1 fractures are spiral wedge fractures. The number of fragments present determines C1 subgroups. C1 subgroups are assigned according to the number of fracture fragments present, with 2 or 3 fragments being classified as C1.1 or C1.2, respectively. Fractures with more than 3 fragments are classified as C1.3 in this system. Segmental fractures are type C2 fractures. C2 fractures, like C1 fractures, are subclassified by the number of fracture fragments present. Highly comminuted fractures are labeled as C2.3. The subdivisions in this group are classified according to the number of fracture fragments and the extent of comminution.

Indications

Most closed tibial fractures can be treated nonoperatively with good result, but infection risk and fracture stability must be considered. Littenberg et al reviewed 2372 case reports of closed tibial fractures and compared clinical outcomes of cast treatment, open reduction and internal fixation, and intramedullary rod therapy. They showed cast treatment to be associated with fewer superficial infections than open reduction and internal fixation. Open reduction and internal fixation, however, demonstrated a higher union rate at 20 weeks.13

In some instances, the fracture cannot be treated properly with nonoperative methods. Operative fixation is required when fractures are unstable. Instability is defined as greater than 1.5 cm of shortening, more than 5° of varus or valgus angulation, 10° of anterior or posterior angulation, and/or less than 50% translation while the leg is in a cast. Factors that contribute to instability are the degree of comminution, the presence of ipsilateral fibular fractures, and the location of the fracture along the tibia. The original presenting radiograph is useful because, often with cast or brace treatment, the original amount of shortening is what the fracture ultimately heals with; therefore, shortening greater than 1 cm is a relative indication for operative stabilization.

Open tibial shaft fracture.

Open tibial shaft fracture.

Open tibial shaft fracture.

Open tibial shaft fracture.


Infection after internal fixation of an open tibi...

Infection after internal fixation of an open tibial shaft fracture.

Infection after internal fixation of an open tibi...

Infection after internal fixation of an open tibial shaft fracture.


Open fractures are surgical emergencies, and an orthopedic surgeon should be consulted immediately. Rarely, a type I fracture can be treated nonoperatively, but most patients should be scheduled for debridement and irrigation within 6 hours of the injury. Longer intervals have been shown to increase rate of infection.14 Patients with Gustilo type II and III open fractures should always be taken to the operating room for irrigation, debridement, and possible surgical fixation (eg, intramedullary nailing, external fixation, plating). Situations in which an open fracture should not be corrected emergently are rare. In some cases, however, especially in the polytrauma scenario, definitive fracture treatment may be delayed. If surgery must be delayed, leg appearance and compartmental pressure must be monitored carefully.

Relevant Anatomy

The leg is divided into 4 distinct fascial compartments. The compartmental anatomy can become extremely important during a traumatic situation in which internal bleeding in the leg can lead to a compartment syndrome.

The anterior compartment contains the dorsiflexors of the foot, including the tibialis anterior, extensor digitorum longus, extensor hallucis, and peroneus tertius. Also housed in the anterior compartment is the deep peroneal nerve. The major blood supply to the anterior compartment is from the anterior tibial artery and its associated vessels.

The lateral compartment contains the peroneus longus and brevis muscles, which primarily serve in eversion of the foot. The superficial peroneal nerve is contained in this compartment and innervates these 2 muscles.

The posterior aspect of the leg is divided into 2 compartments, superficial and deep. The deep compartment contains the plantarflexor muscles, including the tibialis posterior, flexor hallucis longus, and flexor digitorum longus. The peroneal and the posterior tibial arteries also course through this compartment with their corresponding veins. The superficial posterior compartment is the largest of the 4 compartments but contains only muscle. These plantarflexing muscles include the soleus, the gastrocnemius, and the plantaris.

Contraindications

Several contraindications to surgery are recognized for the treatment of tibial shaft fractures. All patients require a thorough preoperative evaluation and must be cleared for general anesthesia prior to any operation, including treatment of tibial shaft fractures. In cases of acute trauma, patients should be stabilized by the trauma team prior to fixation of a tibial shaft fracture. Incision and drainage of infected fracture sites often is indicated; however, hardware should never be placed into an infected wound. In cases in which infected hardware is removed, treat the infection with intravenous antibiotics and replace the hardware in a second surgery after the infection has been treated thoroughly.

More on Tibial Shaft Fractures

Overview: Tibial Shaft Fractures
Workup: Tibial Shaft Fractures
Treatment: Tibial Shaft Fractures
Follow-up: Tibial Shaft Fractures
Multimedia: Tibial Shaft Fractures
References
Further Reading

References

  1. Alho A, Benterud JG, Hogevold HE, et al. Comparison of functional bracing and locked intramedullary nailing in the treatment of displaced tibial shaft fractures. Clin Orthop. Apr 1992;(277):243-50. [Medline].

  2. Court-Brown CM, McBirnie J. The epidemiology of tibial fractures. J Bone Joint Surg Br. May 1995;77(3):417-21. [Medline].

  3. Heyworth BE, Green DW. Lower extremity stress fractures in pediatric and adolescent athletes. Curr Opin Pediatr. Feb 2008;20(1):58-61. [Medline].

  4. Blick SS, Brumback RJ, Lakatos R, et al. Early prophylactic bone grafting of high-energy tibial fractures. Clin Orthop. Mar 1989;(240):21-41. [Medline].

  5. Court-Brown CM, McQueen MM, Quaba AA, Christie J. Locked intramedullary nailing of open tibial fractures. J Bone Joint Surg Br. Nov 1991;73(6):959-64. [Medline].

  6. Court-Brown CM, Wheelwright EF, Christie J, McQueen MM. External fixation for type III open tibial fractures. J Bone Joint Surg Br. Sep 1990;72(5):801-4. [Medline].

  7. Schandelmaier P, Krettek C, Rudolf J, et al. Superior results of tibial rodding versus external fixation in grade 3B fractures. Clin Orthop. Sep 1997;(342):164-72. [Medline].

  8. Tornetta P 3rd, Bergman M, Watnik N, et al. Treatment of grade-IIIb open tibial fractures. A prospective randomised comparison of external fixation and non-reamed locked nailing. J Bone Joint Surg Br. Jan 1994;76(1):13-9. [Medline].

  9. Whittle AP, Russell TA, Taylor JC, Lavelle DG. Treatment of open fractures of the tibial shaft with the use of interlocking nailing without reaming. J Bone Joint Surg Am. Sep 1992;74(8):1162-71. [Medline].

  10. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty- five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. Jun 1976;58(4):453-8. [Medline].

  11. Müller ME, Nazarian S, Koch P. The Comprehensive Classification of Fractures of Long Bones. Berlin, Germany; Springer-Verlag; 1990.

  12. Orthopaedic Trauma Association. Fracture and Dislocation Classification Compendium - 2007 Orthopaedic Trauma Association/Classification, Database & Outcomes Committee. Orthopaedic Trauma Association. Available at http://www.ota.org/compendium/compendium.html. Accessed May 15, 2009.

  13. Littenberg B, Weinstein LP, McCarren M, et al. Closed fractures of the tibial shaft. A meta-analysis of three methods of treatment. J Bone Joint Surg Am. Feb 1998;80(2):174-83. [Medline].

  14. Kindsfater K, Jonassen EA. Osteomyelitis in grade II and III open tibia fractures with late debridement. J Orthop Trauma. Apr 1995;9(2):121-7. [Medline].

  15. Kyro A, Tunturi T, Soukka A. Conservative treatment of tibial fractures. Results in a series of 163 patients. Ann Chir Gynaecol. 1991;80(3):294-300. [Medline].

  16. Karaharju EO, Alho A, Nieminen J. The results of operative and non-operative management of tibial fractures. Injury. Aug 1975;7(1):47-52. [Medline].

  17. van der Linden W, Larsson K. Plate fixation versus conservative treatment of tibial shaft fractures. A randomized trial. J Bone Joint Surg Am. Sep 1979;61(6A):873-8. [Medline].

  18. Sarmiento A. A functional below-the-knee cast for tibial fractures. J Bone Joint Surg Am. Jul 1967;49(5):855-75. [Medline].

  19. Hooper GJ, Keddell RG, Penny ID. Conservative management or closed nailing for tibial shaft fractures. A randomised prospective trial. J Bone Joint Surg Br. Jan 1991;73(1):83-5. [Medline].

  20. Edwards CC. Staged reconstruction of complex open tibial fractures using Hoffmann external fixation. Clinical decisions and dilemmas. Clin Orthop. Sep 1983;(178):130-61. [Medline].

  21. Behrens F, Searls K. External fixation of the tibia. Basic concepts and prospective evaluation. J Bone Joint Surg Br. Mar 1986;68(2):246-54. [Medline].

  22. Wysocki RW, Kapotas JS, Virkus WW. Intramedullary nailing of proximal and distal one-third tibial shaft fractures with intraoperative two-pin external fixation. J Trauma. Apr 2009;66(4):1135-9. [Medline].

  23. Benum P, Svenningsen S. Tibial fractures treated with Hoffmann's external fixation: a comparative analysis of Hoffmann bilateral frames and the Vidal-Adrey double frame modification. Acta Orthop Scand. Jun 1982;53(3):471-6. [Medline].

  24. Court-Brown CM, Hughes SP. Hughes external fixator in treatment of tibial fractures. J R Soc Med. Oct 1985;78(10):830-7. [Medline].

  25. Eidelman M, Katzman A. Treatment of complex tibial fractures in children with the Taylor spatial frame. Orthopedics. Oct 2008;31(10):[Medline].

  26. Gershuni DH, Pinsker R. Bone grafting for nonunion of fractures of the tibia: a critical review. J Trauma. Jan 1982;22(1):43-9. [Medline].

  27. Clifford RP, Lyons TJ, Webb JK. Complications of external fixation of open fractures of the tibia. Injury. May 1987;18(3):174-6. [Medline].

  28. Lawyer RB Jr, Lubbers LM. Use of the Hoffmann apparatus in the treatment of unstable tibial fractures. J Bone Joint Surg Am. Dec 1980;62(8):1264-73. [Medline].

  29. Lefaivre KA, Guy P, Chan H, Blachut PA. Long-term follow-up of tibial shaft fractures treated with intramedullary nailing. J Orthop Trauma. Sep 2008;22(8):525-9. [Medline].

  30. Busse JW, Morton E, Lacchetti C, Guyatt GH, Bhandari M. Current management of tibial shaft fractures: a survey of 450 Canadian orthopedic trauma surgeons. Acta Orthop. Oct 2008;79(5):689-94. [Medline].

  31. Hupel TM, Aksenov SA, Schemitsch EH. Effect of limited and standard reaming on cortical bone blood flow and early strength of union following segmental fracture. J Orthop Trauma. Aug 1998;12(6):400-6. [Medline].

  32. Keating JF, O''Brien PJ, Blachut PA, et al. Locking intramedullary nailing with and without reaming for open fractures of the tibial shaft. A prospective, randomized study. J Bone Joint Surg Am. Mar 1997;79(3):334-41. [Medline].

  33. Court-Brown CM, Will E, Christie J, McQueen MM. Reamed or unreamed nailing for closed tibial fractures. A prospective study in Tscherne C1 fractures. J Bone Joint Surg Br. Jul 1996;78(4):580-3. [Medline].

  34. [Best Evidence] Bhandari M, Guyatt G, Tornetta P 3rd, Schemitsch EH, Swiontkowski M, Sanders D, et al. Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am. Dec 2008;90(12):2567-78. [Medline].

  35. Brinker MR, Bailey DE Jr. Fracture healing in tibia fractures with an associated vascular injury. J Trauma. Jan 1997;42(1):11-9. [Medline].

  36. Lange RH, Bach AW, Hansen ST Jr, Johansen KH. Open tibial fractures with associated vascular injuries: prognosis for limb salvage. J Trauma. Mar 1985;25(3):203-8. [Medline].

  37. Taylor JC. Delayed union and non-union of fractures. In: Crenshaw AH, ed. Campbell's Operative Orthopaedics. 8th ed. St Louis, Mo: CV Mosby; 1992:. 1287.

  38. Templeman D, Thomas M, Varecka T, Kyle R. Exchange reamed intramedullary nailing for delayed union and nonunion of the tibia. Clin Orthop. Jun 1995;169-75. [Medline].

  39. Coles CP, Gross M. Closed tibial shaft fractures: management and treatment complications. A review of the prospective literature. Can J Surg. Aug 2000;43(4):256-62. [Medline].

  40. McGraw JM, Lim EV. Treatment of open tibial-shaft fractures. External fixation and secondary intramedullary nailing. J Bone Joint Surg Am. Jul 1988;70(6):900-11. [Medline].

  41. Milner SA, Davis TR, Muir KR, et al. Long-term outcome after tibial shaft fracture: is malunion important?. J Bone Joint Surg Am. Jun 2002;84-A(6):971-80. [Medline].

  42. Clifford RP, Beauchamp CG, Kellam JF, et al. Plate fixation of open fractures of the tibia. J Bone Joint Surg Br. Aug 1988;70(4):644-8. [Medline].

  43. den Outer AJ, Meeuwis JD, Hermans J, Zwaveling A. Conservative versus operative treatment of displaced noncomminuted tibial shaft fractures. A retrospective comparative study. Clin Orthop. Mar 1990;(252):231-7. [Medline].

  44. Digby JM, Holloway GM, Webb JK. A study of function after tibial cast bracing. Injury. Mar 1983;14(5):432-9. [Medline].

  45. Duda GN, Mandruzzato F, Heller M, et al. Mechanical boundary conditions of fracture healing: borderline indications in the treatment of unreamed tibial nailing. J Biomech. May 2001;34(5):639-50. [Medline].

  46. Hussain R, Umer M, Umar M. Treatment of tibial diaphyseal fractures with closed flexible intramedullary ender nails: 39 fractures followed for a period of two to seven years. J Pak Med Assoc. May 2001;51(5):190-3. [Medline].

  47. Jensen JS, Hansen FW, Johansen J. Tibial shaft fractures. A comparison of conservative treatment and internal fixation with conventional plates or AO compression plates. Acta Orthop Scand. 1977;48(2):204-12. [Medline].

  48. Karladani AH, Granhed H, Fogdestam I, Styf J. Salvaged limbs after tibial shaft fractures with extensive soft-tissue injury: a biopsychosocial function analysis. J Trauma. Jan 2001;50(1):60-4. [Medline].

  49. Skoog A, Soderqvist A, Tornkvist H, Ponzer S. One-year outcome after tibial shaft fractures: results of a prospective fracture registry. J Orthop Trauma. Mar-Apr 2001;15(3):210-5. [Medline].

  50. Toivanen JA, Honkonen SE, Koivisto AM, Jarvinen MJ. Treatment of low-energy tibial shaft fractures: plaster cast compared with intramedullary nailing. Int Orthop. 2001;25(2):110-3. [Medline].

Keywords

Compartment Syndrome, Lower Extremity, tibial shaft fracture, tibia fracture, broken leg, broken bone, trauma, leg fracture, fractured leg, fractured tibia, broken tibia, compartment syndrome

Contributor Information and Disclosures

Author

Brian K Konowalchuk, MD, Staff Physician, Department of Orthopedic Surgery, University of Minnesota College of Medicine
Brian K Konowalchuk, MD is a member of the following medical societies: Alpha Omega Alpha
Disclosure: Nothing to disclose.

Coauthor(s)

Nicholas J Wills, MD, Fellow, Twin Cities Spine Center
Disclosure: Nothing to disclose.

Brian Tollefson, MD, Flight Surgeon, United States Air Force
Disclosure: Nothing to disclose.

Marc Swiontkowski, MD, Chair, Professor, Department of Orthopedic Surgery, University of Minnesota at Minneapolis
Marc Swiontkowski, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, American Orthopaedic Association, and Canadian Orthopaedic Association
Disclosure: Nothing to disclose.

Medical Editor

Charles T Mehlman, DO, MPH, Director, Musculoskeletal Outcomes Research, Associate Professor, Division of Pediatric Orthopedic Surgery, Cincinnati Children's Hospital Medical Center
Charles T Mehlman, DO, MPH is a member of the following medical societies: American Academy of Pediatrics, American Fracture Association, American Medical Association, American Orthopaedic Foot and Ankle Society, American Osteopathic Association, Arthroscopy Association of North America, North American Spine Society, Ohio State Medical Association, Pediatric Orthopaedic Society of North America, and Scoliosis Research Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Shepard R Hurwitz, MD, Executive Director, American Board of Orthopaedic Surgery
Shepard R Hurwitz, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association for the Advancement of Science, American College of Rheumatology, American College of Sports Medicine, American College of Surgeons, American Diabetes Association, American Orthopaedic Association, American Orthopaedic Foot and Ankle Society, Association for the Advancement of Automotive Medicine, Eastern Orthopaedic Association, Orthopaedic Research Society, Orthopaedic Trauma Association, and Southern Orthopaedic Association
Disclosure: Nothing to disclose.

CME Editor

Dinesh Patel, MD, FACS, Associate Clinical Professor of Orthopedic Surgery, Harvard Medical School; Chief of Arthroscopic Surgery, Department of Orthopedic Surgery, Massachusetts General Hospital
Dinesh Patel, MD, FACS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Physicians of Indian Origin, American College of International Physicians, and American College of Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Carlos J Lavernia, MD, FAAOS, Adjunct Clinical Professor, Department of Orthopedic Surgery, University of Miami School of Medicine; Medical Director, Orthopedic Institute at Mercy Hospital
Carlos J Lavernia, MD, FAAOS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of Hip and Knee Surgeons, Arthritis Foundation, Biomedical Engineering Society, Florida Orthopaedic Society, and Orthopaedic Research Society
Disclosure: Zimmer Stock Implant Designer

 
 
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